DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Est-Q and Est-P

DIOPT Version :9

Sequence 1:	NP_649321.1	Gene:	Est-Q / 40381	FlyBaseID:	FBgn0037090	Length:	559	Species:	Drosophila melanogaster
Sequence 2:	NP_788501.1	Gene:	Est-P / 39393	FlyBaseID:	FBgn0000594	Length:	544	Species:	Drosophila melanogaster

Alignment Length:	517	Identity:	136/517 - (26%)
Similarity:	220/517 - (42%)	Gaps:	80/517 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 SETATVTVELYNGQGTVLGNYAYTAWTDRAFMQFRGIPFAEPPIEELRFRPPVARS-PWTGTLNA 100
            ||...:.||:.||:.....|..|        ..:..||.||.|...|||..|...| .||...||
  Fly    20 SEADPLIVEITNGKIRGKDNGLY--------YSYESIPNAEHPTGALRFEAPQPYSHHWTDVFNA 76

  Fly   101 LNFGQRC----PVITNLDSQMSDAELEDCLTLSVY--TKNLSASQPVMFYIYGGGFYNGSSEDHP 159
            ......|    ..|...:..|.|   |||||:|:|  .|...:|.||:..::||.|..||...:.
  Fly    77 TQSPVECMQWNQFINENNKLMGD---EDCLTVSIYKPKKPNRSSFPVVVLLHGGAFMFGSGSIYG 138

  Fly   160 PNYLLEKDVVLVVP-QYRVGALGWLSTYTEELPGNAPIADILMALDWVQMHISSFGGDPQKVTIF 223
            .:.::.:..:|||. .:.:|.||:.||....||||..:.|..:||.|::.:|:.|||.|..:.:.
  Fly   139 HDSIMREGTLLVVKISFGLGPLGFASTGDRHLPGNYGLKDQRLALQWIKKNIAHFGGMPDNIVLI 203

  Fly   224 GQSAGAGVASSLLLSPKTGDNMFKRAIVQSGSIFASWAINKDPKAQSRRICIQLGCSGCEQHDQL 288
            |.||| |.::.|.|..:...::.|.||..||:....|.|.:..:.::..:...:||.......:|
  Fly   204 GHSAG-GASAHLQLLHEDFKHLAKGAISVSGNALDPWVIQQGGRRRAFELGRIVGCGHTNVSAEL 267

  Fly   289 VKCIQKAKVIDILKATAS---------ESFSPIV--GDL-HGILPQQPSELVKSYR-RQIPILTG 340
            ..|::.....||:.|..|         .:|.|:|  .|. ...|.:.|..::||.: .|:|....
  Fly   268 KDCLKSKPASDIVSAVRSFLVFSYVPFSAFGPVVEPSDAPDAFLTEDPRAVIKSGKFAQVPWAVT 332

  Fly   341 FTQHDGSFVLASYYDALAAKVANVSSLSVRQFSQGIN--DLVND-------------TSGLTDNI 390
            :|..||.:              |.:.|..|....|.:  ||:||             .:..|...
  Fly   333 YTTEDGGY--------------NAAQLLERNKLTGESWIDLLNDRWFDWAPYLLFYRDAKKTIKD 383

  Fly   391 LNRLLFKPQALNSHDHSAAVSSYFD---LTTNIFMKSPVITLATKMYTQQRSTPVYVYSFEYEG- 451
            ::.|.|..:.....|...:|.||::   :.|::..|:.|.: |..::.:...:|  ||||.|:.
  Fly   384 MDDLSFDLRQQYLADRRFSVESYWNVQRMFTDVLFKNSVPS-AIDLHRKYGKSP--VYSFVYDNP 445

  Fly   452 TYTRFGYEFGNS---HYPFNGGVHHSNDNIYLFATHP----LEGQDTQMSQKMVDVWTSFAI 506
            |.:..|....|.   |:    |..|.:|...:|.|..    :...:..:|:|.:.:...||:
  Fly   446 TDSGVGQLLSNRTDVHF----GTVHGDDFFLIFNTAAYRTGIRPDEEVISKKFIGMLEDFAL 503

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Est-Q	NP_649321.1	COesterase	39..544	CDD:278561	134/515 (26%)
Est-Q	NP_649321.1	Aes	<137..>240	CDD:223730	36/103 (35%)
Est-P	NP_788501.1	Esterase_lipase	26..537	CDD:238191	134/511 (26%)
Est-P	NP_788501.1	Aes	<107..>240	CDD:223730	43/133 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	98	1.000	Domainoid score	I1867
eggNOG	1	0.900	-	-		E2759_KOG1516
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	99	1.000	Inparanoid score	I1664
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	1	1.000	-	-		otm46967
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X33
	7	6.860