DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Est-Q and Est-6

DIOPT Version :9

Sequence 1:	NP_649321.1	Gene:	Est-Q / 40381	FlyBaseID:	FBgn0037090	Length:	559	Species:	Drosophila melanogaster
Sequence 2:	NP_001261749.1	Gene:	Est-6 / 39392	FlyBaseID:	FBgn0000592	Length:	544	Species:	Drosophila melanogaster

Alignment Length:	599	Identity:	144/599 - (24%)
Similarity:	246/599 - (41%)	Gaps:	120/599 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 GLTAFLVIFLTGGQGADASETATVTVELYNGQGTVLGNYAYTAWTDRAFMQFRGIPFAEPPIEEL 83
            ||...|.....|...:|..:...|.:.    ||.:.|.      .:.::..:..||:||||..:|
  Fly     7 GLIIVLSCLWLGSNASDTDDPLLVQLP----QGKLRGR------DNGSYYSYESIPYAEPPTGDL 61

  Fly    84 RFRPPVA-RSPWTGTLNA-------LNFGQRCPVITNLDSQMSDAELEDCLTLSVYTKNLSA--S 138
            ||..|.. :..|:...:|       |.:.|..|....|..:      |||||:|||....|.  |
  Fly    62 RFEAPEPYKQKWSDIFDATKTPVACLQWDQFTPGANKLVGE------EDCLTVSVYKPKNSKRNS 120

  Fly   139 QPVMFYIYGGGFYNGSS-EDHPPNYLLEKDVVLVVPQYRVGALGWLSTYTEELPGNAPIADILMA 202
            .||:.:|:||.|..|:: ::...|.:.|...:||...||:|.||::||...:||||..:.|..:|
  Fly   121 FPVVAHIHGGAFMFGAAWQNGHENVMREGKFILVKISYRLGPLGFVSTGDRDLPGNYGLKDQRLA 185

  Fly   203 LDWVQMHISSFGGDPQKVTIFGQSAGAGVASSLLLSPKTGDNMFKRAIVQSGSIFASWAINKDPK 267
            |.|::.:|:||||:||.|.:.|.||| |.:..|.:..:....:.:.|...||:....|.|.|..:
  Fly   186 LKWIKQNIASFGGEPQNVLLVGHSAG-GASVHLQMLREDFGQLARAAFSFSGNALDPWVIQKGAR 249

  Fly   268 AQSRRICIQLGCSGCEQHDQLVKCIQKAKVIDILKATAS---------ESFSPIV--GDL-HGIL 320
            .::..:...:||...|....|.||::.....:::.|...         ..|||::  .|. ..|:
  Fly   250 GRAFELGRNVGCESAEDSTSLKKCLKSKPASELVTAVRKFLIFSYVPFAPFSPVLEPSDAPDAII 314

  Fly   321 PQQPSELVKSYR-RQIPILTGFTQHDGSFVLASYYDALAAKVANVSSLSVRQFSQGINDLVNDTS 384
            .|.|.:::||.: .|:|....:...||.      |:|         :|.:::...||  :::|.:
  Fly   315 TQDPRDVIKSGKFGQVPWAVSYVTEDGG------YNA---------ALLLKERKSGI--VIDDLN 362

  Fly   385 GLTDNILNRLLFKPQALNSHD---------------HSAAVSSYFDLT---TNIFMKSPVITLAT 431
            .....:...|||........|               ....:.||.:|.   |:|..|:.. ..:.
  Fly   363 ERWLELAPYLLFYRDTKTKKDMDDYSRKIKQEYIGNQRFDIESYSELQRLFTDILFKNST-QESL 426

  Fly   432 KMYTQQRSTPVYVYSFE-------YEGTYTRFGYEFGNSHYPFNGGVHHSNDNIYLFATHPLEGQ 489
            .::.:...:|.|.|.::       .:....|..|:||..|          .|:.:|...:.:  :
  Fly   427 DLHRKYGKSPAYAYVYDNPAEKGIAQVLANRTDYDFGTVH----------GDDYFLIFENFV--R 479

  Fly   490 DTQM-------SQKMVDVWTSFAIEGVPRNLSPLSSASG--PYNKLNLEVTKGDDLLDTLTAAID 545
            |.:|       |:..:::...||           ||.:|  .|.:.:.:...|.:....|...||
  Fly   480 DVEMRPDEQIISRNFINMLADFA-----------SSDNGSLKYGECDFKDNVGSEKFQLLAIYID 533

  Fly   546 DPDNGRLQREDMEF 559
            ...|    |:.:||
  Fly   534 GCQN----RQHVEF 543

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Est-Q	NP_649321.1	COesterase	39..544	CDD:278561	133/562 (24%)
Est-Q	NP_649321.1	Aes	<137..>240	CDD:223730	41/105 (39%)
Est-6	NP_001261749.1	Esterase_lipase	29..537	CDD:238191	135/565 (24%)
Est-6	NP_001261749.1	Aes	<110..>243	CDD:223730	47/133 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	98	1.000	Domainoid score	I1867
eggNOG	1	0.900	-	-		E2759_KOG1516
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	99	1.000	Inparanoid score	I1664
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	1	1.000	-	-		otm46967
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X33
	7	6.860