DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Est-Q and Jhedup

DIOPT Version :9

Sequence 1:	NP_649321.1	Gene:	Est-Q / 40381	FlyBaseID:	FBgn0037090	Length:	559	Species:	Drosophila melanogaster
Sequence 2:	NP_611085.2	Gene:	Jhedup / 36779	FlyBaseID:	FBgn0034076	Length:	559	Species:	Drosophila melanogaster

Alignment Length:	589	Identity:	169/589 - (28%)
Similarity:	273/589 - (46%)	Gaps:	100/589 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 VLTAGLTAFLVIFLTGGQGADASETATVTVE-LYNGQGTVLGNYAYTAWTDRAFMQFRGIPFAEP 78
            :|.||....|.:.:..|...|      |.:| :...:||::..|     ....|..|.|||||:|
  Fly     1 MLFAGFGVLLFVAVAVGDSLD------VCLEDMGCMRGTLMPGY-----QSGEFEAFMGIPFAQP 54

  Fly    79 PIEELRFRPPVARSPWTGTLNALNFGQRCPVITNLDSQMSDAELEDCLTLSVY-TKNLSASQ-PV 141
            |:..||.:.||...||.|.|:|......|...:....:.....:||||.|:|| .||.:..: ||
  Fly    55 PVGPLRLKNPVPNEPWEGVLDAGAAKDSCIQRSYFAKEWGLMGVEDCLYLNVYRPKNRAEDKLPV 119

  Fly   142 MFYIYGGGFYNGSSEDHP----PNYLLEKD-VVLVVPQYRVGALGWLSTYTEELPGNAPIADILM 201
            |.||:||||::||:  ||    |.||::.: ||:|...||:|..|:|||..|.:|||....|..:
  Fly   120 MVYIHGGGFFSGSA--HPMASGPEYLMDTNKVVMVTMNYRLGPFGFLSTGDEHMPGNFGFKDQRL 182

  Fly   202 ALDWVQMHISSFGGDPQKVTIFGQSAGAGVASSL-LLSPKTGDNMFKRAIVQSGSIFAS-WAINK 264
            ||.|:|.||::|||||:|||:.|.||| |:::.| ::||.: ..:|:.::..:|::|.| ..|.|
  Fly   183 ALQWIQKHIATFGGDPKKVTVLGHSAG-GISAHLHMISPNS-KGLFQNSMSLTGTMFLSAMKILK 245

  Fly   265 DPKAQSRRICIQLGCSGCEQ--------------HDQLVKCIQKAKVID---------ILKATAS 306
            ||.:|:||:..:|.....|.              ..:|:..:...||.|         :|:|.:.
  Fly   246 DPLSQARRLGKELAIDQAESLSSQDLAEALRNVCPKKLLVSVDSLKVWDNMPHLTTLPVLEAPSP 310

  Fly   307 ESFSPIVGDLHGILPQQPSELVKSYR-RQIPILTGFTQHDGS---FVLASYYDALAAKVANVSSL 367
            ::|          |.:.|.:..::.| .|:|.:...:...|.   |::.::.:.......|
  Fly   311 DAF----------LVEDPLDAHRAGRINQMPWILSLSSRAGEGSLFIMRAFINPKLRAEFN---- 361

  Fly   368 SVRQFSQGINDLVNDTSG----LTDNILNRLLFKPQALNSHD--HSAAVSSYFDLTTNIFMK-SP 425
              ..|.:.:..|:|...|    :...||:...||..:||:..  ..|.:|..|:....|:.. |.
  Fly   362 --ENFLEHMALLLNLPEGTPVQMVSEILDAYDFKGDSLNNDTMLKLAEISGDFNFYYPIYETISS 424

  Fly   426 VITLATKMYTQQRSTPVYVYSFEYEG--TYTRFGYEFGNSHYPFNGGVHHSNDNIYL------FA 482
            .:|     |......|:::|.||:.|  :.|:|   |..:...:..|..|.:|.::.      |.
  Fly   425 YVT-----YANLEENPLFIYIFEFAGLNSITKF---FAGTTDDYGLGAVHMDDGLHTIRIPVSFD 481

  Fly   483 THPLEGQDTQMSQKMVDVWTSFAIEGV--PRNLSPLS--SASGPYNKLNLEVTKGDDLLD----- 538
            ..|.:.:|.::.|:|..:.|.||..||  ..::..:|  ...|..|.|:....|...|.|
  Fly   482 DFPKDSEDAKVIQRMSSLMTDFAKTGVFHEESICKVSDFKEQGMCNYLHFGGNKEKYLEDIRNSI 546

  Fly   539 TLTA 542
            ||||
  Fly   547 TLTA 550

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Est-Q	NP_649321.1	COesterase	39..544	CDD:278561	163/565 (29%)
Est-Q	NP_649321.1	Aes	<137..>240	CDD:223730	52/109 (48%)
Jhedup	NP_611085.2	COesterase	31..508	CDD:278561	148/509 (29%)
Jhedup	NP_611085.2	Aes	<106..>210	CDD:223730	53/106 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	98	1.000	Domainoid score	I1867
eggNOG	1	0.900	-	-		E2759_KOG1516
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	99	1.000	Inparanoid score	I1664
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D206516at33208
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	1	1.000	-	-		otm46967
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X33
	8	7.870