DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Est-Q and CG4382

DIOPT Version :9

Sequence 1:	NP_649321.1	Gene:	Est-Q / 40381	FlyBaseID:	FBgn0037090	Length:	559	Species:	Drosophila melanogaster
Sequence 2:	NP_609301.2	Gene:	CG4382 / 34279	FlyBaseID:	FBgn0032132	Length:	580	Species:	Drosophila melanogaster

Alignment Length:	623	Identity:	174/623 - (27%)
Similarity:	286/623 - (45%)	Gaps:	117/623 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 MLTLCGVLTAGLTAFLVIFLTGGQGADAS------------------ETATVTVELYNGQGTVLG 55
            |..|||.:      .|:..|..||.:|..                  ....:|..|...:||:|
  Fly     1 MWRLCGFV------LLLCGLASGQNSDEDLSKAIPDEEDPIGSNKELSDLVITTALGKIRGTIL- 58

  Fly    56 NYAYTAWTDRAFMQFRGIPFAEPPIEELRFRPPVARSPWTGTLNALNFGQRCPVITNLDSQMSDA 120
                .:.:.|.|..|||||:|:||::.|||:||.....|..||:|...|.:||.:..:...:|
  Fly    59 ----PSQSGRNFYAFRGIPYAKPPVDRLRFQPPEPVEQWFDTLDATFDGPKCPQLGLVSGDVS-- 117

  Fly   121 ELEDCLTLSVYTKNL-SASQ-----PVMFYIYGGGFY--NGSSEDHP-PNYLLEKDVVLVVPQYR 176
              ||||.:::|||.| |.||     ||:.:|:.||||  :|.|::.. |.|.:.:.:|||...||
  Fly   118 --EDCLRVNIYTKELPSESQPNVRRPVIVFIHPGGFYSLSGQSKNFAGPQYFMNRRLVLVTFNYR 180

  Fly   177 VGALGWLSTYTEELPGNAPIADILMALDWVQMHISSFGGDPQKVTIFGQSAGAGVASSLLLSPKT 241
            :|:||:|:|.|.|.|||..:.|.:..|.||::|||.|||||..:|:.|..|||...:..::||.:
  Fly   181 LGSLGFLATGTREAPGNMGLKDQVQLLRWVKLHISRFGGDPSSITLLGYGAGAMAVTLHMVSPMS 245

  Fly   242 GDNMFKRAIVQSGSIFASWAINKDPKAQSRRICIQLGCSGCEQHDQLVKCIQKAKVIDILKATAS 306
             ..:|.:|||.||::...|::.......:.:....|.|. .|...:::.|::....::... |..
  Fly   246 -RGLFHKAIVMSGAVTGQWSLPDHQMDVATKQATLLHCH-TENVTEMMDCLKGKHYLEFAN-TLP 307

  Fly   307 ESF-----------SPIVGDLHG---ILPQQPSELVKSYRR----QIPILTGFTQHDGSFV---- 349
            :.|           .|::....|   .|.::|   ::||:.    ::||:||.|:.:  ||
  Fly   308 KMFEFDRNNPLILWKPVIEPDFGQERFLVEEP---IRSYQNDDFMKVPIITGMTKDE--FVGPAL 367

  Fly   350 -LASYYDALAAKVANVSSLSVRQFSQGINDLVNDTSGLTDNILNRL---LFKPQALNSHDHSAAV 410
             :......|:|...|..||:...|      :.|.:.....||...|   .|..:.::::....|:
  Fly   368 SILQSPTLLSALNENFESLAPVFF------MYNTSDARACNISQELRNHYFPDKLIDANRSLEAL 426

  Fly   411 SS-YFDLTTNIFMKSPVITLATKMYTQQRSTPVYVYSFEYEGTYTRFGYEFGNSHYPFNG--GVH 472
            |: |.|..|. |.....:.||.      |||.||.|.|.|:|..:..       :||.:.  ||.
  Fly   427 SNLYSDALTG-FGIHRFVHLAA------RSTKVYYYRFSYQGARSHI-------YYPEDAPYGVV 477

  Fly   473 HSNDNIYLFATHPL------EGQDTQMSQKMVDVWTSFAIEGVPRNLSPLSSAS---GPYN---K 525
            |.:|.:|||....:      :..:.:|...||.::::||.:|.|...:.|:...   .|::   :
  Fly   478 HHDDLMYLFVEPSISRMFTEDDDEFRMVDIMVRMFSAFAYKGDPNKPTDLALRDIRWRPFSFKKR 542

  Fly   526 LNLEVTKGDDLLDTLTAAIDD------PDNGRLQREDM 557
            ..|::.|...|.:.|.|...:      |.|.|.|.:::
  Fly   543 YYLDIGKHITLEENLNAENYEIWKRLFPLNWRRQTKEV 580

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Est-Q	NP_649321.1	COesterase	39..544	CDD:278561	161/554 (29%)
Est-Q	NP_649321.1	Aes	<137..>240	CDD:223730	46/110 (42%)
CG4382	NP_609301.2	COesterase	41..565	CDD:278561	161/560 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	98	1.000	Domainoid score	I1867
eggNOG	1	0.900	-	-		E2759_KOG1516
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	99	1.000	Inparanoid score	I1664
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D206516at33208
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	1	1.000	-	-		otm46967
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X33
	8	7.870