DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Est-Q and CG9289

DIOPT Version :9

Sequence 1:	NP_649321.1	Gene:	Est-Q / 40381	FlyBaseID:	FBgn0037090	Length:	559	Species:	Drosophila melanogaster
Sequence 2:	NP_609245.1	Gene:	CG9289 / 34195	FlyBaseID:	FBgn0032058	Length:	674	Species:	Drosophila melanogaster

Alignment Length:	553	Identity:	186/553 - (33%)
Similarity:	281/553 - (50%)	Gaps:	43/553 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 GQGADASETATVTVELYNGQGTVLGNYAYTAWTDRAFMQFRGIPFAEPPIEELRFRPPVARSPWT 95
            ||.....:..|.||.   ..|.:.|....|.||.:..|||..||:.:..    ||||......|.
  Fly    67 GQNGQEPKVFTTTVP---DLGRLRGRTLTTDWTGQKIMQFLDIPYGKAE----RFRPAEPAPSWK 124

  Fly    96 GTLNALNFGQRCPVITNL----DSQMSDAELEDCLTLSVYTKNLSA-SQPVMFYIYGGGFYNGSS 155
            |.|.|......||.|.:|    ..:....::||||.|||.||.:.. |.|||.||:|..||:|.|
  Fly   125 GVLPAHRPHAGCPSIQDLIVFAKLEEDGFDVEDCLRLSVNTKAMEGKSLPVMVYIHGDFFYDGDS 189

  Fly   156 EDHPPNYLLEKDVVLVVPQYRVGALGWLSTYTEELPGNAPIADILMALDWVQMHISSFGGDPQKV 220
            .:..|.||||.|||||..:||:|..|:|||.|:|:||||.:.||::||.|||.||:|||||||:|
  Fly   190 VEAAPGYLLEHDVVLVSVRYRLGPFGFLSTLTDEMPGNAAVTDIILALKWVQQHIASFGGDPQRV 254

  Fly   221 TIFGQSAGAGVASSLLLSPKTGDNMFKRAIVQSGSIFASWAINKDPKAQSRRICIQLGCSGCEQH 285
            |:|||..||.:.:.|.|||.....:|.|.|.|||:..:...|...|...::.|....||....:.
  Fly   255 TLFGQVGGAALVNVLTLSPAVPAGLFHRVIYQSGTALSPAFITDAPLGATKAIGRIAGCKQSTKV 319

  Fly   286 DQLVKCIQKAKVIDILKATA-----SESFSP--------IVGDLHGILPQQPSELVKSYRRQ-IP 336
            |||.||:.:.....:|.|.:     ..|.|.        ::|...||||:.|..|:.:.:.| .|
  Fly   320 DQLNKCLNRLNATMLLAAFSVHGENQPSLSGGAYGGVQLVIGGPSGILPEHPGRLLAAEKFQAYP 384

  Fly   337 ILTGFTQHDGSFVLASYYDALAAKVANVSSLSVRQFSQGINDLVN--DTSGLTDNILNRLLFKPQ 399
            .:.|..:|.|:|:|...:..:..:.....:::.||:...|.:..|  |.||......:..:|...
  Fly   385 TMGGSVKHGGTFMLRDIFADIFNETILDDTMTGRQYIDTIIEQANGADPSGSWKEFSDEEIFTQN 449

  Fly   400 ALNSHDHSAAVSSYFDLTTNIFMKSPVITLATKMYTQQRSTPVYVYSFEYEGTYTRFGYEFGNSH 464
            .:.:...........||.:.|.:|:||: |..:...::.....|:|||:|||...|:......::
  Fly   450 DVKNGTFKRLTPGLIDLCSTISLKNPVL-LVLQANAKKLPNSTYLYSFDYEGEQNRYATGEDEAN 513

  Fly   465 Y-PFNGGVHHSNDNIYLFATHPL----EGQDTQMSQKMVDVWTSFAIEGVPRNLSP-------LS 517
            : ||:.||..::||:|||.....    ..:|.:::::||.:|||||..|||:  :|       ::
  Fly   514 FVPFDMGVSLTDDNLYLFPWPRFLALNSNRDLKVARRMVALWTSFATTGVPQ--APGLPAWPAMN 576

  Fly   518 SASGPYNKLNLEVTKGDDLLDTLTAAIDDPDNG 550
            ..:|||.|::..|:.||:.||....|:::..:|
  Fly   577 DETGPYMKIDRTVSFGDNYLDEYRIAVEEAKHG 609

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Est-Q	NP_649321.1	COesterase	39..544	CDD:278561	182/537 (34%)
Est-Q	NP_649321.1	Aes	<137..>240	CDD:223730	60/103 (58%)
CG9289	NP_609245.1	COesterase	83..600	CDD:278561	179/523 (34%)
CG9289	NP_609245.1	Aes	<171..351	CDD:223730	81/179 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG25739
OrthoDB	1	1.010	-	-		D206516at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm46967
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR43142
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	6	5.930