DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Est-Q and Glt

DIOPT Version :9

Sequence 1:	NP_649321.1	Gene:	Est-Q / 40381	FlyBaseID:	FBgn0037090	Length:	559	Species:	Drosophila melanogaster
Sequence 2:	NP_001245946.1	Gene:	Glt / 34193	FlyBaseID:	FBgn0001114	Length:	1026	Species:	Drosophila melanogaster

Alignment Length:	514	Identity:	149/514 - (28%)
Similarity:	246/514 - (47%)	Gaps:	60/514 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    51 GTVLGNYAYTAWTDRAFMQFRGIPFAEPPIEELRFRPPVARSP--WTGTLNALNFGQRCPVITNL 113
            |.:||...:....:|....|.||.:........||:   |..|  :.|.:||......|.....|
  Fly    68 GQILGISGHKTIANRPVNAFLGIRYGTVGGGLARFQ---AAQPIGYQGRVNATVQSPNCAQFPEL 129

  Fly   114 D----SQMSDAELEDCLTLSVYTKNLSASQPVMFYIYGGGFYNGSSEDHPPNYLLEKDVVLVVPQ 174
            |    |:.....::|||||.:|....:...||:.:::|...::|.||:..|:|:|||||:||...
  Fly   130 DRLRLSESRGENVDDCLTLDIYAPEGANQLPVLVFVHGEMLFDGGSEEAQPDYVLEKDVLLVSIN 194

  Fly   175 YRVGALGWLSTYTEELPGNAPIADILMALDWVQMHISSFGGDPQKVTIFGQSAGAGVASSLLLSP 239
            ||:...|:||..|:|||||..::|:.:||:|:|.::..|||:..:||:.||:.||.:|.:|.||.
  Fly   195 YRLAPFGFLSALTDELPGNVALSDLQLALEWLQRNVVHFGGNAGQVTLVGQAGGATLAHALSLSG 259

  Fly   240 KTGDNMFKRAIVQSGSIFASWAINKDP---------KAQSRRICIQLGCSGCEQHDQLVKCIQKA 295
            :.| |:|::.|:|||:....:.|:..|         .|:.....|.....|.:   .|..|:.:.
  Fly   260 RAG-NLFQQLILQSGTALNPYLIDNQPLDTLSTFARLARCPPPSINPSAQGLK---PLYDCLARL 320

  Fly   296 KVIDILKA-------------TASESFSPIVGDLHGILPQQPSELVKSYRRQIPILTGFTQHDGS 347
            ....::.|             |....|..:|||..|.||..|:.|..:....:|::.|.|:...:
  Fly   321 PTSQLVAAFEQLLLQNEHLGLTQLGGFKLVVGDPLGFLPSHPASLATNSSLALPMIIGATKDASA 385

  Fly   348 FVLASYYDALAAKVANVSSLSVRQFSQGINDLVNDTSGLTDNIL-----NRLLFKPQALNSHDHS 407
            |:::..||.||       .|..|..|..|:.::..|:..:::.|     .|.:|.|....:....
  Fly   386 FIVSRIYDQLA-------RLQSRNVSDYIDVVLRHTAPPSEHRLWKQWALREIFTPIQEQTASLQ 443

  Fly   408 AAVSSYFDLTTNIFMKSPVITLATKMYTQQRSTPVYVYSFEYEGTYTRFGYEFGNSHYPFNGGVH 472
            .......:|:..|..::|||...::.|   ||.|.|:|:|:|.|.:.|||:.  ::..||.....
  Fly   444 TVAPGLLELSNYILYRAPVINSISQSY---RSVPAYLYTFDYRGEHHRFGHL--SNPLPFGVDAS 503

  Fly   473 HSNDNIYLFATHP----LEGQDTQMSQKMVDVWTSFAIEGVPRNLSPL----SSASGPY 523
            .|:|::|||...|    |...|..:|:.:|.:|.:||..|||...|.:    :|..||:
  Fly   504 LSDDSVYLFPYPPEASRLNPLDRSLSRALVTMWVNFATTGVPNPSSGVWPQATSEYGPF 562

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Est-Q	NP_649321.1	COesterase	39..544	CDD:278561	149/514 (29%)
Est-Q	NP_649321.1	Aes	<137..>240	CDD:223730	44/102 (43%)
Glt	NP_001245946.1	COesterase	55..579	CDD:278561	149/514 (29%)
		Aes	<146..345	CDD:223730	64/202 (32%)
		RILP-like	<677..>717	CDD:304877
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D206516at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR43142
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	3.020