DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Est-Q and cel.1

DIOPT Version :9

Sequence 1:	NP_649321.1	Gene:	Est-Q / 40381	FlyBaseID:	FBgn0037090	Length:	559	Species:	Drosophila melanogaster
Sequence 2:	NP_955901.2	Gene:	cel.1 / 322481	ZFINID:	ZDB-GENE-030131-1201	Length:	550	Species:	Danio rerio

Alignment Length:	573	Identity:	159/573 - (27%)
Similarity:	260/573 - (45%)	Gaps:	109/573 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 GLTAFLVIFLTGGQGADASETATVTVELYNGQGTVLGNYAYTAWTDRAFMQFRGIPFAEPPIEEL 83
            |:....|:||...|||......| ...:..|:...:|.:.|       ...|:|||||.||   .
Zfish     5 GVFISAVLFLGTAQGASLGAVLT-EGGMVQGKSRSVGLFRY-------MDTFKGIPFAAPP---K 58

  Fly    84 RFRPPVARSPWTGTLNALNFGQRCPVITNLDSQMSDAELEDCLTLSVYT---KNLSASQPVMFYI 145
            ||..|||...|.|.|...::.:||..:..|.:.:..:  ||||.|:::.   :.:|::.|||.:|
Zfish    59 RFEKPVAHPGWEGVLKTTDYRKRCLQLNLLATDVIGS--EDCLYLNIWVPQGRTVSSNLPVMVFI 121

  Fly   146 YGGGFY--NGSSEDHPPNYLLEKD-------VVLVVPQYRVGALGWLSTYTEELPGNAPIADILM 201
            |||.|.  .|...:...|||.:.:       |::|...|||||||::||..:.:|||..:.|...
Zfish   122 YGGAFLLGGGQGANFLDNYLYDGEEMADRGNVIVVTFNYRVGALGFMSTGDDGIPGNYGLWDQHA 186

  Fly   202 ALDWVQMHISSFGGDPQKVTIFGQSAGAGVASSLLLSPKTGDNMFKRAIVQSGSIFASWAINKDP 266
            |:.||..:|.:|||:|..:|:||:||||...:..:::|| ...|.:|||.|||.....|||:::|
Zfish   187 AISWVHRNIKAFGGNPDNITLFGESAGAASVNFQIITPK-NKGMIRRAISQSGVALCPWAISRNP 250

  Fly   267 KAQSRRICIQLGC---SGCEQHDQLVKCIQKA--KVIDI---LKATASESFSPIVGDLHGILPQQ 323
            :..:..|..::||   ||      :..|:::|  |.:.:   ||.|:|.. :|||.:|:
Zfish   251 RQFAEEIATKVGCPIDSG------MADCLKRADPKAVTLAGKLKLTSSPD-APIVHNLY------ 302

  Fly   324 PSELVKSYRRQIPILTGFTQHDGSFVLASYYDALAAKVANVSSLSVRQFSQGINDLVNDTSGLTD 388
                      ..|::      ||.|: ....:.|....|::..::      |:||:........|
Zfish   303 ----------LSPVI------DGDFI-PDEPETLFGNAADIDYIA------GVNDMDAHIFATID 344

  Fly   389 --NILNRLLFKP----QAL-----NSHDHSAAVSSYFDLTTN-------IFMKSPVITLATK-MY 434
              :|.|.|...|    |||     ......|.::::.:.|.|       ..:|..|:.|.|. |:
Zfish   345 IPSINNALTTTPVEEVQALATALSRDRGQDAGIATFQEYTVNWGDKPNKEKVKQTVVELETDYMF 409

  Fly   435 TQQRSTPVYVYSFEYEGTYTRFGYEFGNSH----YPFNGGVHHSNDNIYL----FATHPLE--GQ 489
            .......:|:::...:...| |.|.|..|.    :|...|..|:::..|:    ||| ||.  .:
Zfish   410 LVPTQAALYLHTDNAKSART-FSYLFTESSRIPVFPLWMGADHADELQYVFGKPFAT-PLGYFPR 472

  Fly   490 DTQMSQKMVDVWTSFAIEG--------VPRNLSPLSSASGPYNKLNLEVTKGD 534
            ...:|:.|:..|::||..|        ||......|:....|..:|.::.|.:
Zfish   473 HRDVSKYMIAYWSNFAQTGDPNKGESKVPVTWPEFSNPGHQYLDINNKMNKNN 525

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Est-Q	NP_649321.1	COesterase	39..544	CDD:278561	152/553 (27%)
Est-Q	NP_649321.1	Aes	<137..>240	CDD:223730	42/111 (38%)
cel.1	NP_955901.2	COesterase	25..517	CDD:306613	150/543 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D206516at33208
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.820