Protein Alignment Est-Q and Nceh1

DIOPT Version :10

• Sequence 1: NP_649321.1
• Gene: Est-Q / 40381
• FlyBaseID: FBgn0037090
• Length: 559
• Species: Drosophila melanogaster
• Sequence 2: NP_848887.1
• Gene: Nceh1 / 320024
• MGIID: 2443191
• Length: 408
• Species: Mus musculus
• Alignment Length: 373
• Identity: 66/373 - (17%)
• Similarity: 120/373 - (32%)
• Gaps: 126/373 - (33%)

  Fly   199 ILMALDWVQMHISSFGGDPQKVTIFGQS-AGAGVASSLLLSPKTGDNMFKRAIVQSGSIFASWAI 262
            :.:|..:|.:.:.|...||.|:.:...: .||...|:|:.|  .|.|   ..::....|..|:.
Mouse    12 LALAAYYVYIPLPSAVSDPWKLMLLDATFRGAQQVSNLIHS--LGLN---HHLIALNFIITSFG- 70

  Fly   263 NKDPKAQSRRICIQLGCSGCEQHDQLVKCIQKAKVIDILKATASESFSPIVGDLHGI-------- 319
                                   .|..:...|.||.|.              |..|:
Mouse    71 -----------------------KQSARSSPKVKVTDT--------------DFDGVEVRVFEGS 98

  Fly   320 -LPQQPSELVKSYRRQIPILTGFTQHDGSFVLA----SYYDALAAKVAN-----VSSLSVR---- 370
             .|::|      .||.:..:     |.|.:.||    ||||.|...:|.     :.|:..|
Mouse    99 PKPEEP------LRRSVIYI-----HGGGWALASAKISYYDQLCTTMAEELNAVIVSIEYRLVPQ 152

  Fly   371 -QFSQGINDLVNDTSGLTDNILNRLLFKPQALNSH----------------DHSAAVSSYFDLTT 418
             .|.:.|:|::..|         :...:|:.|:.:                :.:||:...|....
Mouse   153 VYFPEQIHDVIRAT---------KYFLQPEVLDKYKVDPGRVGISGDSAGGNLAAALGQQFTYVA 208

  Fly   419 NIFMKSPVITLA----------TKMYTQQRSTPVYVYSFEYEGTYTRFGYEFGNSHYPFNGGVHH 473
            ::..|..:..|.          |..|.|..:||:..     .....|:..::...:|.|...:..
Mouse   209 SLKNKLKLQALVYPVLQALDFNTPSYQQSMNTPILP-----RHVMVRYWLDYFKGNYDFVEAMIV 268

  Fly   474 SNDNIYLFATHPLEGQDTQMSQKMVDVWTSFAIEGVPRNLSPLSSASG 521
            :|..       .|:.:.....:..:| |||.....:.:|..|:...:|
Mouse   269 NNHT-------SLDVERAAALRARLD-WTSLLPSSIKKNYKPIMQTTG 308

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Est-Q	NP_649321.1	COesterase	50..536	CDD:395084	66/373 (18%)
Nceh1	NP_848887.1	Abhydrolase_3	109..381	CDD:400284	40/227 (18%)
		Involved in the stabilization of the negatively charged intermediate by the formation of the oxyanion hole. /evidence=ECO:0000250|UniProtKB:Q5NUF3	113..115		1/1 (100%)