DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Est-Q and Ces5a

DIOPT Version :9

Sequence 1:	NP_649321.1	Gene:	Est-Q / 40381	FlyBaseID:	FBgn0037090	Length:	559	Species:	Drosophila melanogaster
Sequence 2:	NP_001012056.2	Gene:	Ces5a / 307660	RGDID:	1549717	Length:	575	Species:	Rattus norvegicus

Alignment Length:	554	Identity:	153/554 - (27%)
Similarity:	238/554 - (42%)	Gaps:	108/554 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    50 QGTVLGNYAYTAWTDRAFMQFRGIPFAEPPIEELRFRPPVARSPWTGTLNALNFGQRCPVITNLD 114
            |.||||..       .....|.|||||.||:..|||..|....||.....|..:...|  ..||:
  Rat    44 QATVLGRL-------EPVNVFLGIPFAAPPLGPLRFSNPQPPIPWHDLREATTYPNVC--FQNLE 99

  Fly   115 SQMSDAEL-----------EDCLTLSVYT---KNLSASQPVMFYIYGGGFYNGSSEDHPPNYLLE 165
            .......|           ||||.|::|.   .|..:..|||.:|.||||..||:.....:.|..
  Rat   100 WLFIYQNLLKVHYPKLGVSEDCLYLNIYAPAYANDGSRLPVMMWIPGGGFETGSASIFDGSALAA 164

  Fly   166 -KDVVLVVPQYRVGALGWLSTYTEELPGNAPIADILMALDWVQMHISSFGGDPQKVTIFGQSAGA 229
             :||::|..|||:|..|:.:|..:..|||....|.|.||.||:.:|:.|||:|..|||||.||||
  Rat   165 YEDVLIVTIQYRLGIFGFFNTQNQHAPGNWAFQDQLAALQWVRENINYFGGNPDSVTIFGGSAGA 229

  Fly   230 GVASSLLLSPKTGDNMFKRAIVQSGSIFASWAINKDPKAQSRRICIQLGCSGCEQHDQ--LVKCI 292
            ...|||:|||.:. .:|.|||:|||........|.|.:.:.....:...|. |...|.  |:||:
  Rat   230 ISISSLILSPLSA-GLFHRAIMQSGVAIIPSLKNFDDELKHGLQVVADVCK-CNVSDSKVLLKCL 292

  Fly   293 QKAKVIDILK-ATASESFSPIVGDLHGILPQQPSELV--KSYRRQIPILTGFTQHDGSFVLASYY 354
            ::...:::|. ...:::|:.:|..  ...|::|.||:  |:: :.:|.:.|....:..::
  Rat   293 REKSSLELLSLGQKTKAFTRVVDG--SFFPEEPMELLSQKTF-KTVPSIIGVNNQECGYI----- 349

  Fly   355 DALAAKVANVSSLSVRQ-----FSQGINDLVNDTSGLTDNILNRLL-FKPQALN---------SH 404
                        |.:|:     |..      |:::.||  :::.|| ..||.::         .|
  Rat   350 ------------LPMREAPEILFGS------NESTALT--LIHVLLHIPPQYMHIVAKDYFHGKH 394

  Fly   405 DHSAAVSSYFDLTTNIFMKSPVITLATKMYTQQRSTPVYVYSFEYEGTYTRFGYEFGNSHYPFNG 469
            ..:....:..||..::|...|  .|.|....:....|||.|.|::....      |.|:. |...
  Rat   395 SLTDIRDTLLDLFGDVFFVVP--GLVTARNHRDAGGPVYFYEFQHRPNC------FQNTR-PAFV 450

  Fly   470 GVHHSNDNIYLFATHPLEG----------QDTQMSQKMVDVWTSFAIEGVPRN----LSPLSSAS 520
            ...|:::..::|....|||          .:..:|:||:..|.:||..|.|..    |.|....:
  Rat   451 KADHTDEIRFVFGGPFLEGDVVMFEEATEDEKLLSRKMMSYWANFARSGDPNGDDLPLWPAYDQN 515

  Fly   521 GPYNKLNLEVTKG-----------DDLLDTLTAA 543
            ..|.||::.::.|           .|.|..:|:|
  Rat   516 ESYLKLDVNISTGWRLKDRRVEFWTDTLPLITSA 549

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Est-Q	NP_649321.1	COesterase	39..544	CDD:278561	153/554 (28%)
Est-Q	NP_649321.1	Aes	<137..>240	CDD:223730	48/103 (47%)
Ces5a	NP_001012056.2	Esterase_lipase	40..529	CDD:238191	148/532 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	5	4.770