DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Est-Q and Ces4a

DIOPT Version :9

Sequence 1:	NP_649321.1	Gene:	Est-Q / 40381	FlyBaseID:	FBgn0037090	Length:	559	Species:	Drosophila melanogaster
Sequence 2:	NP_001099646.1	Gene:	Ces4a / 291955	RGDID:	1307418	Length:	563	Species:	Rattus norvegicus

Alignment Length:	567	Identity:	158/567 - (27%)
Similarity:	239/567 - (42%)	Gaps:	84/567 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 LTAGLTAFLVIFLTGGQGADASETATVTVE--LYNGQGTVLGNYAYTAWTDRAFMQFRGIPFAEP 78
            |...||.:||:....|        |..|.|  |....|.:.|...:..  |.....|.|:||::|
  Rat    12 LDLSLTLWLVVQTALG--------ALHTKEPLLITKHGILQGKQVHVG--DTPIRVFLGVPFSQP 66

  Fly    79 PIEELRFRPPVARSPWTGTLNALNF---------GQRCPVITNLDSQMSDAEL-EDCLTLSVYTK 133
            |:...||.||....||.|..:|..:         ||...:..|...|...... ||||.|:||..
  Rat    67 PVGTRRFAPPEPPLPWNGIRDATTYPPSCLQESWGQITSMYLNTRKQYEWLHFSEDCLYLNVYAP 131

  Fly   134 NLSASQ---PVMFYIYGGGFYNGSSEDHPPNYLLEK-DVVLVVPQYRVGALGWLSTYTEELPGNA 194
            .|:...   |||.:..||.|..||:..:..:.|..: .||||..|||:|.||:.||......||.
  Rat   132 VLAPGDPLLPVMVWFPGGAFLVGSASTYEGSELAARGKVVLVFLQYRLGILGFFSTGNSHARGNW 196

  Fly   195 PIADILMALDWVQMHISSFGGDPQKVTIFGQSAGAGVASSLLLSPKTGDNMFKRAIVQSGSIFAS 259
            .:.|.:.||.|||.:|.:|||||..||:|||||||...|.||:|| ....:|.:||.|||:....
  Rat   197 GLLDQIAALRWVQENIEAFGGDPDSVTLFGQSAGAMSVSGLLMSP-LAQGLFHQAISQSGTAVLK 260

  Fly   260 WAINKDPKAQSRRICIQLGCSGCEQHDQ---LVKCIQKAKVIDILKATASESF------------ 309
            ..|..||...:::|....||    .|:.   :|||::......::..:...:|
  Rat   261 TFITHDPLKSAKKIAHLAGC----DHNSTKIMVKCLKALPAEKVMLVSKKMTFFRANSHKDPKDI 321

  Fly   310 ----SPIVGDLHGILPQQPSELV-KSYRRQIPILTGFTQHDGSFVLASYYD-ALAAKVANVSSLS 368
                ||:|..|  :.|:.|..|: :...:.:|.|.|....:..:.|..... .|..::.|.:.::
  Rat   322 VWFLSPVVDGL--VFPEDPVVLLTRGQVKPVPYLLGVNSAEFEWSLPFLMKLQLNQRIMNKNYIT 384

  Fly   369 VRQFSQGINDLVNDTSGLTDNILNRLLFKPQALNSHDHSAAVSSYFDL---TTNIFMKSPVITLA 430
            ...:|..|  |:|.|......:....|  ..|::.||.....:...||   .|.::     .||.
  Rat   385 KLLWSCSI--LLNITEEQIPLVAREYL--SDAISHHDWKMFRNHLIDLVGDATFVY-----ATLQ 440

  Fly   431 TKMYTQQRSTPVYVYSFEYEGTYTRFGYEFGNSHYPFNGGVHHSNDNIYLFATHPL-----EGQD 490
            ...|.:...:|||:|.|::...        |....|.:.|..|.::..|||.: |.     .|::
  Rat   441 AARYHRDAGSPVYLYEFKHHAP--------GIIVKPRSDGADHGDELSYLFGS-PFSKGSSRGEE 496

  Fly   491 TQMSQKMVDVWTSFAIEGVPRNLS----PLSSASGPYNKLNLEVTKG 533
            .:.|.:|:..|.:||..|.|.:..    |.......|.:|:.:...|
  Rat   497 KEFSLQMMKYWANFAHTGDPNDRELPYWPRFDKEEKYLQLDFDTRVG 543

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Est-Q	NP_649321.1	COesterase	39..544	CDD:278561	152/544 (28%)
Est-Q	NP_649321.1	Aes	<137..>240	CDD:223730	48/106 (45%)
Ces4a	NP_001099646.1	COesterase	33..554	CDD:395084	150/538 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D206516at33208
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	6	5.780