DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Est-Q and Ces2a

DIOPT Version :9

Sequence 1:	NP_649321.1	Gene:	Est-Q / 40381	FlyBaseID:	FBgn0037090	Length:	559	Species:	Drosophila melanogaster
Sequence 2:	NP_653344.1	Gene:	Ces2a / 246252	RGDID:	708353	Length:	558	Species:	Rattus norvegicus

Alignment Length:	569	Identity:	151/569 - (26%)
Similarity:	254/569 - (44%)	Gaps:	93/569 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 YVMLTLCGVLTAGLTAFLVIFLTGGQGADASETATVTVELYNGQGTVLGNYAYTAWTDRAFMQFR 71
            ::.:..||         |::.|....|.|::.....|   :.||  |.|::.:...|......|.
  Rat     9 WLYVVACG---------LLLLLQHVHGQDSASPIRNT---HTGQ--VRGSFVHVKDTKSGIHTFL 59

  Fly    72 GIPFAEPPIEELRFRPPVARSPWTGTLNALNFGQRC--PVITNLDSQMSDAEL--------EDCL 126
            |||||:||:..|||.||....||:|..:|.:....|  ..|.|||. :.:.:|        ||||
  Rat    60 GIPFAKPPVGPLRFAPPEDPEPWSGVRDATSQPAMCLQTDIMNLDG-IKEMKLTVHPTPMSEDCL 123

  Fly   127 TLSVYT-------KNLSASQPVMFYIYGGGFYNGSSEDHPPNYL-LEKDVVLVVPQYRVGALGWL 183
            .|::||       .||    |||.:|:|||...||:..:..:.| ..:::|:|..|||:|.||:.
  Rat   124 YLNIYTPAHAREGSNL----PVMVWIHGGGLVLGSASMNDASTLAATEEIVIVSIQYRLGVLGFF 184

  Fly   184 STYTEELPGNAPIADILMALDWVQMHISSFGGDPQKVTIFGQSAGAGVASSLLLSPKTGDNMFKR 248
            ||..:...||....|.:.||.|||.:|:.|||:..||||||.|||....||.::||.: ..:|..
  Rat   185 STGDQNARGNWGYLDQVAALRWVQQNIAYFGGNHGKVTIFGGSAGGTSVSSHVVSPMS-KGLFHG 248

  Fly   249 AIVQSGSIFASWAINKDPKAQSRRICIQLGCSGCEQHDQ--LVKCIQKAKVIDILKATASESFSP 311
            ||:|||.......|:...:...:.:.   ..||||..|.  |::|::.....:||  ..::.|..
  Rat   249 AIMQSGVALLPDLISDKSEVVYKTVA---NLSGCEAPDSEALIRCLRAKSKQEIL--AINQVFKM 308

  Fly   312 IVGDLHG-ILPQQPSELVKSYR-RQIPILTGFTQHDGSFVLASY--YDALAAKVANVSSLSVRQF 372
            |.|.:.| .||:.|.||:.|.. ..:|.:.|....:..:.:..:  .|.:..|:...:..:|.:.
  Rat   309 IPGVVDGKFLPKHPQELLASGDFHPVPSIIGINTDECGWGIPVFLGLDHIIKKITRETLPTVLKS 373

  Fly   373 S--------QGINDLVNDTSGLTDNILNRLLFKPQALNSHDHSAAVSSYFDLTTNIFMKSPVITL 429
            :        :.|:.::.:..|.|:|        |:.|.        ..:..:..:.....|.:.:
  Rat   374 TAAQMMLPPECIDLIMEEYMGDTEN--------PETLQ--------EQFRHMLGDFMFVIPALQV 422

  Fly   430 ATKMYTQQRSTPVYVYSFEYEGTYTRFGYEFGNSHYPFNGGVHHSNDNIYLFA------THPLEG 488
            |   :.|:...|||.|.|::..::.:   :...||..    ..|.:|.:::|.      |..|..
  Rat   423 A---HFQRSQAPVYFYEFQHLPSFIK---QVRPSHVK----ADHGDDILFVFGSYLWGMTFDLTE 477

  Fly   489 QDTQMSQKMVDVWTSFAIEGVPRNLS----PLSSASGPYNKLNLEVTKG 533
            ::..:.::::..|.:||..|.|....    |:......|.:||.:...|
  Rat   478 EEELLKRRVMKYWANFARTGNPNGEDLPHWPVLDHDEQYLQLNTQPAVG 526

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Est-Q	NP_649321.1	COesterase	39..544	CDD:278561	145/537 (27%)
Est-Q	NP_649321.1	Aes	<137..>240	CDD:223730	44/103 (43%)
Ces2a	NP_653344.1	COesterase	30..537	CDD:395084	145/539 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.910