DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Est-Q and Ces1a

DIOPT Version :9

Sequence 1:	NP_649321.1	Gene:	Est-Q / 40381	FlyBaseID:	FBgn0037090	Length:	559	Species:	Drosophila melanogaster
Sequence 2:	NP_001013786.2	Gene:	Ces1a / 244595	MGIID:	3648919	Length:	563	Species:	Mus musculus

Alignment Length:	502	Identity:	142/502 - (28%)
Similarity:	226/502 - (45%)	Gaps:	65/502 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    50 QGTVLGNYAYTAWTDRAFMQFRGIPFAEPPIEELRFRPPVARSPWTGTLNALNFGQRCPVITNLD 114
            ||.|:|.|.....:.:....|.|:|||:||:..|||.||.....|:...|..::...|..||.:.
Mouse    30 QGKVMGKYISLEGSAQPVAVFLGVPFAKPPLGPLRFAPPQPAETWSSVKNTTSYPPMCSQITGVG 94

  Fly   115 SQMSDA---EL--------EDCLTLSVYTKNLSASQ---PVMFYIYGGGFYNGSSEDHPPNYL-L 164
            ..:||.   :|        ||||.|::|:.....|:   |||.:::|||..:|.:.......| .
Mouse    95 PVLSDVFTNQLENVPLEYSEDCLYLNIYSPTDLTSKDRLPVMVWVHGGGLLSGGASTFDGLALST 159

  Fly   165 EKDVVLVVPQYRVGALGWLSTYTEELPGNAPIADILMALDWVQMHISSFGGDPQKVTIFGQSAGA 229
            .::||:||.|||:|..|:|||..|...||....|.:.||.|||.:|::|||||..||:||:|||.
Mouse   160 HENVVIVVIQYRLGIWGFLSTGDEHSRGNWGHLDQVAALQWVQNNIANFGGDPSSVTLFGESAGG 224

  Fly   230 GVASSLLLSPKTGDNMFKRAIVQSGSIFASWAINKDPKAQSRRICIQLGCSGCEQHDQLVKCIQK 294
            ...|.|:|||.| .|:|:|||.:||.........:..:..:.::.|..||......| :|.|:::
Mouse   225 ESVSVLVLSPLT-KNLFQRAISESGVALTPCLFRETTRRAAEQVAIATGCVATTSAD-IVHCLRE 287

  Fly   295 AKVIDILKATASESFSPIVGDLHG----------------ILPQQPSELV--KSYRRQIPILTGF 341
            ....::|..|....|..:  ||.|                :||:.|.|::  ||: ..:|.:.|.
Mouse   288 KTEEELLATTLKMKFFAL--DLLGDPRESYPFLTTVIDGVVLPKAPEEILAEKSF-NTVPYIVGI 349

  Fly   342 TQHD-GSFV-LASYYDALAAKVANVSSLSVRQFSQGINDLVND-TSGLTDNILNRLLFKPQALNS 403
            .:.: |.|: :...|.....|:...|:.|:...|..:.::..: |...|:..|.         .|
Mouse   350 NKQEFGWFIPMMMGYPLSEGKLDQKSATSLLWKSYPLTNISKELTPVATEKYLG---------GS 405

  Fly   404 HDHSAAVSSYFDLTTNIFMKSPVITLATKMYTQQRSTPVYVYSFEYEGTYTRFGYEFGNSHYPFN 468
            .........:.|:..::....|.:.:|  .|.:....|.|:|.|:|..:       |.:...|..
Mouse   406 DCPDKKKDLFLDMMGDVLFAVPSVIVA--RYHRDAGAPTYMYEFKYHPS-------FVSDMRPKT 461

  Fly   469 GGVHHSNDNIYLFATHPL--EG---QDTQMSQKMVDVWTSFAIEGVP 510
            ....| .|.:|.....|.  ||   ::..:|..|:..|.:||..|.|
Mouse   462 VIADH-GDEVYSVWGTPFLKEGASEEEINLSTMMMKFWGNFARNGNP 507

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Est-Q	NP_649321.1	COesterase	39..544	CDD:278561	142/502 (28%)
Est-Q	NP_649321.1	Aes	<137..>240	CDD:223730	47/106 (44%)
Ces1a	NP_001013786.2	Esterase_lipase	25..536	CDD:238191	142/502 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D206516at33208
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.820