DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Est-Q and Ces4a

DIOPT Version :9

Sequence 1:	NP_649321.1	Gene:	Est-Q / 40381	FlyBaseID:	FBgn0037090	Length:	559	Species:	Drosophila melanogaster
Sequence 2:	NP_666325.2	Gene:	Ces4a / 234677	MGIID:	2384581	Length:	563	Species:	Mus musculus

Alignment Length:	543	Identity:	150/543 - (27%)
Similarity:	231/543 - (42%)	Gaps:	84/543 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 LTLCGVLTAGLTAFLVIFLTGGQGADASETATVTVELYNGQGTVLGNYAYTAWTDRAFMQFRGIP 74
            ||||.|:...|.|.           ...|...:|     ..|.:.|...:..  |.....|.|||
Mouse    16 LTLCLVVQTALGAL-----------HTKEPLLIT-----KHGILQGKQVHVG--DTPIQVFLGIP 62

  Fly    75 FAEPPIEELRFRPPVARSPWTGTLNALNF---------GQRCPVITNLDSQMSDAEL-EDCLTLS 129
            |::||:...||.||....||.|..:|..:         ||...:..|...|...... ||||.|:
Mouse    63 FSKPPVGTRRFAPPEPPLPWNGIRDATTYPPSCLQESWGQILSMYLNTRKQYKWLHFSEDCLYLN 127

  Fly   130 VYTKNLSASQ---PVMFYIYGGGFYNGSSEDHPPNYLLEK-DVVLVVPQYRVGALGWLSTYTEEL 190
            ||...|:...   |||.:..||.|..||:..:..:.|..: .||||..|||:|.||:.||.....
Mouse   128 VYAPVLAPGAPLLPVMVWFPGGAFLAGSASTYEGSELAARGKVVLVFLQYRLGILGFFSTGNSHA 192

  Fly   191 PGNAPIADILMALDWVQMHISSFGGDPQKVTIFGQSAGAGVASSLLLSPKTGDNMFKRAIVQSGS 255
            .||..:.|.:.||.|||.:|.:|||||..||:|||||||...|.|::|| ....:|.:||.|||:
Mouse   193 RGNWGLLDQIAALRWVQENIEAFGGDPDSVTLFGQSAGAMSVSGLMVSP-LAQGLFHQAISQSGT 256

  Fly   256 IFASWAINKDPKAQSRRICIQLGCSGCEQHDQ---LVKCIQKAKVIDILKATASESF-------- 309
            ......|..||...:::|....||    .|:.   :|:|::.....::...:...||
Mouse   257 AVLKAFITPDPLTSAKKIAHLAGC----DHNSTKVMVECLRSLSAEEVTLVSKRMSFFQANSHKD 317

  Fly   310 --------SPIVGDLHGILPQQPSELV-KSYRRQIPILTGFTQHDGSFVLASYYDALAAKVANVS 365
                    ||:|..:  :.|:.|..|: :...:.:|.|.|....:..:.| .:...:......::
Mouse   318 PKEIVWFLSPVVDGV--VFPEDPVVLLTRGQVKPVPYLLGVNNAEFEWNL-PFLMKIQLNQRMMN 379

  Fly   366 SLSVRQFSQGINDLVNDTSGLTDNILNRLLFKPQALNSHDHSAAVSSYFDL---TTNIFMKSPVI 427
            ..::.:.....|.|:|.|......:....|  ..|:::||.....:...||   .|.::     .
Mouse   380 QTNINKILWSFNVLLNITKEQVPVVAREYL--NDAISNHDWKMFRNRLIDLIGDATFVY-----A 437

  Fly   428 TLATKMYTQQRSTPVYVYSFEYEGTYTRFGYEFGNSHYPFNGGVHHSNDNIYLFATHPLE----- 487
            ||....|.:...:|||:|.|::..:       .|....|:| |..|.::..|||.: |..
Mouse   438 TLQAARYHRDAGSPVYLYEFKHHAS-------SGIIIKPYN-GADHGDELSYLFGS-PFSKGSSA 493

  Fly   488 GQDTQMSQKMVDVWTSFAIEGVP 510
            |::.:.|.:|:..|.:||..|.|
Mouse   494 GEEKEFSLQMMKYWANFAHTGNP 516

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Est-Q	NP_649321.1	COesterase	39..544	CDD:278561	142/514 (28%)
Est-Q	NP_649321.1	Aes	<137..>240	CDD:223730	47/106 (44%)
Ces4a	NP_666325.2	COesterase	30..554	CDD:278561	143/518 (28%)
Ces4a	NP_666325.2	Aes	<128..>272	CDD:223730	60/144 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D206516at33208
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	6	5.780