Protein Alignment Est-Q and NLGN1

DIOPT Version :9

• Sequence 1: NP_649321.1
• Gene: Est-Q / 40381
• FlyBaseID: FBgn0037090
• Length: 559
• Species: Drosophila melanogaster
• Sequence 2: NP_001352852.1
• Gene: NLGN1 / 22871
• HGNCID: 14291
• Length: 843
• Species: Homo sapiens
• Alignment Length: 602
• Identity: 155/602 - (25%)
• Similarity: 251/602 - (41%)
• Gaps: 137/602 - (22%)

  Fly     4 RGVYVMLTLCGVLTAGLTAFLVIFLTGGQGADASETATVT---------VELYNGQGTVLGNYAY 59
            ||:...|||| :|...|.|..|:    .|..|..:....|         .||.|   .:||
Human    23 RGLGAPLTLC-MLGCLLQAGHVL----SQKLDDVDPLVATNFGKIRGIKKELNN---EILG---- 75

  Fly    60 TAWTDRAFMQFRGIPFAEPPIEELRFRPPVARSPWTGTLNALNFGQRCP---------------- 108
                  ..:||.|:|:|.||..|.||:||...|||:...||..|...||
Human    76 ------PVIQFLGVPYAAPPTGERRFQPPEPPSPWSDIRNATQFAPVCPQNIIDGRLPEVMLPVW 134

  Fly   109 VITNLD---SQMSDAELEDCLTLSVYT--------------------------KNLSASQPVMFY 144
            ...|||   |.:.| :.||||.|::|.                          ::....:|||.|
Human   135 FTNNLDVVSSYVQD-QSEDCLYLNIYVPTEDGPLTKKQTDDLGDNDGAEDEDIRDSGGPKPVMVY 198

  Fly   145 IYGGGFYNGSSEDHPPNYLLE-KDVVLVVPQYRVGALGWLSTYTEELPGNAPIADILMALDWVQM 208
            |:||.:..|:...:..:.|.. .:|:::...||:|.||:|||..:...||..:.|::.||.|...
Human   199 IHGGSYMEGTGNLYDGSVLASYGNVIVITVNYRLGVLGFLSTGDQAAKGNYGLLDLIQALRWTSE 263

  Fly   209 HISSFGGDPQKVTIFGQSAGAGVASSLLLSPKTGDN--------MFKRAIVQSGSIFASWAINKD 265
            :|..|||||.::|:||..||....:.|.||..:..|        :|:|||.|||:..:|||::..
Human   264 NIGFFGGDPLRITVFGSGAGGSCVNLLTLSHYSEGNRWSNSTKGLFQRAIAQSGTALSSWAVSFQ 328

  Fly   266 PKAQSRRICIQLGCSGCEQHDQLVKCIQK---AKVI--DILKATASESFSPIV-GDLHGILPQQP 324
            |...:|.:..::||: .....:||:|:||   .:::  ||..|....:|.|:: ||   ::|..|
Human   329 PAKYARMLATKVGCN-VSDTVELVECLQKKPYKELVDQDIQPARYHIAFGPVIDGD---VIPDDP 389

  Fly   325 SELVK-----SYRRQIPILTGFTQHDGSFVLASYYDALAAKVANVSSLSVRQFSQGINDLVNDTS 384
            ..|::     :|    .|:.|..|.:|...:.:..|       :...:|...|...:::.|::..
Human   390 QILMEQGEFLNY----DIMLGVNQGEGLKFVENIVD-------SDDGISASDFDFAVSNFVDNLY 443

  Fly   385 GLTD--NILN---RLLFKPQALNSHDHSAAVSSYFDLTTNIFMKSPVITLATKMYTQQRSTPVYV 444
            |..:  ::|.   :.::...| :.|:......:...|.|:....:|.:  ||........:|.|.
Human   444 GYPEGKDVLRETIKFMYTDWA-DRHNPETRRKTLLALFTDHQWVAPAV--ATADLHSNFGSPTYF 505

  Fly   445 YSFEYEGTYTRFGYEFGNSHYPFNGGVHHSNDNIYLFATHPLEG-----------QDTQMSQKMV 498
            |:| |....|        ...|......|.::..|:... |:.|           .|..:|..::
Human   506 YAF-YHHCQT--------DQVPAWADAAHGDEVPYVLGI-PMIGPTELFPCNFSKNDVMLSAVVM 560

  Fly   499 DVWTSFAIEGVPRNLSP 515
            ..||:||..|.|....|
Human   561 TYWTNFAKTGDPNQPVP 577

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Est-Q	NP_649321.1	COesterase	39..544	CDD:278561	143/567 (25%)
		Aes	<137..>240	CDD:223730	38/103 (37%)
NLGN1	NP_001352852.1	COesterase	53..626	CDD:365897	143/567 (25%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810