DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Est-Q and cest-28

DIOPT Version :9

Sequence 1:	NP_649321.1	Gene:	Est-Q / 40381	FlyBaseID:	FBgn0037090	Length:	559	Species:	Drosophila melanogaster
Sequence 2:	NP_504691.2	Gene:	cest-28 / 187305	WormBaseID:	WBGene00019654	Length:	548	Species:	Caenorhabditis elegans

Alignment Length:	552	Identity:	148/552 - (26%)
Similarity:	230/552 - (41%)	Gaps:	146/552 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    51 GTVLGNYAYTAWTDRAFMQFRGIPFAEPPIEELRFRPPVARSPWTGTLNALNFGQRC----PVIT 111
            |.:.||.....  |:....:.|||||:|.:   ||:.|.....|....:...:|.||    |...
Worm    22 GPIQGNVYRIG--DKTVDGYLGIPFAKPLV---RFKKPEPAGTWEEVRDCTKYGPRCPQSGPFAE 81

  Fly   112 NLDSQMSDAELE-DCLTLSVY-----TKNLSASQPVMFYIYGGGFYNGSSEDH----PPNYLLEK 166
            .::.|..|...| :||||:|:     :||.:.::|||.||:|||:...:|.|:    ....|..|
Worm    82 AINFQKDDIPDEANCLTLNVFSKISDSKNFNKTRPVMVYIHGGGYECSASRDYCDYSVAGTLPLK 146

  Fly   167 DVVLVVPQYRVGALGWLSTYTEELPGNAPIADILMALDWVQMHISSFGGDPQKVTIFGQSAGAGV 231
            |||:|...||||.||:.:|.....|||..:.|:.:.|:|:|.||.||||||..:|||||||||..
Worm   147 DVVVVTLNYRVGILGFFTTGDTVCPGNFALWDLTLGLNWIQKHIESFGGDPGNITIFGQSAGAAC 211

  Fly   232 ASSLLLSPKTGDNMFKRAIVQSGSIFASWAINKDPKAQSRRICIQ----LGCSGCEQHDQLVKCI 292
            ...|.|||.:.| :|.|.||.||.....:|: :...:|: ::|.:    ||..|  .:.|.:...
Worm   212 VDLLALSPHSRD-LFNRVIVMSGGALCEYAV-RTANSQA-KVCYEFARHLGYDG--TNSQTLFNW 271

  Fly   293 QKAKVIDILK--------ATASESFSPIVGDLHGILPQQPSELVKSYRRQIP---ILTGFTQHDG 346
            .|:|.::.::        |:...:::|.:.|  ...|:...||    |...|   |:.||.:|:|
Worm   272 MKSKPLEEIEKMNGFQVPASGILAWTPNLDD--DFFPKSLDEL----RIGAPKKDIMMGFAEHEG 330

  Fly   347 SFV-------------------------LASYYDALAAKV-----ANVSSLSVRQFSQGINDLVN 381
            .|.                         ...:::|...|:     .||.....:...:.:.|.|.
Worm   331 LFFEFLIKDPTPPLEALKLYVNEYYKKDTGDHFEATRNKIIEFYSRNVEDTDEKSTKERLIDFVG 395

  Fly   382 D---TSGLTDNILNRLLFKPQALNSHDHSAAVSSYFDLTTNIFMKSPVITLATKMYTQQRSTPVY 443
            |   |:|:.||..|.|        .|.::                                  |:
Worm   396 DALFTAGVFDNAKNCL--------KHGNN----------------------------------VW 418

  Fly   444 VYSFEY---EGTYTRFGYEFGNSHYPFNGGV--HHSNDNIYLFAT------HPLEGQDTQMSQKM 497
            :|.|:|   .|        |||.. .|...|  .|..|..|:...      .|.| ::.:|.:||
Worm   419 LYIFDYCNPSG--------FGNQE-EFMTFVAPTHCTDLRYVLGEGLYSDFQPTE-EEHKMIEKM 473

  Fly   498 VDVWTSFAIEGVPRNLSPLSSASGPYNKLNLE 529
            ..::::||..|     :|....|..:.|..|:
Worm   474 TTIYSNFAKYG-----NPNEHGSSEWEKFTLD 500

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Est-Q	NP_649321.1	COesterase	39..544	CDD:278561	148/552 (27%)
Est-Q	NP_649321.1	Aes	<137..>240	CDD:223730	50/106 (47%)
cest-28	NP_504691.2	COesterase	17..516	CDD:278561	148/552 (27%)
cest-28	NP_504691.2	Aes	<112..>222	CDD:223730	51/109 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D206516at33208
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X33
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.820