DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Est-Q and cest-30

DIOPT Version :9

Sequence 1:	NP_649321.1	Gene:	Est-Q / 40381	FlyBaseID:	FBgn0037090	Length:	559	Species:	Drosophila melanogaster
Sequence 2:	NP_504407.1	Gene:	cest-30 / 181871	WormBaseID:	WBGene00015071	Length:	578	Species:	Caenorhabditis elegans

Alignment Length:	586	Identity:	154/586 - (26%)
Similarity:	255/586 - (43%)	Gaps:	91/586 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 GLTAFLVIFLTGGQGADASETATVTVELYNGQ-GTVLGN-YAYTAWTDRAFMQFRGIPFAEPPIE 81
            |:...|:..:.||...:.  |.....::.|.. |.:.|| |.:...| :....:.|||||:.|:.
Worm     8 GIGCLLLSIVEGGFLVNL--TPEKNSQILNAPCGPIRGNIYKHKNGT-KIVDGYLGIPFAKAPVG 69

  Fly    82 ELRFRPPVARSPWTGTLNALNFGQRCP-----VITNLDSQMSDAELEDCLTLSVYTKNLSASQ-- 139
            .|:|:.|||...||...:...:|..||     ......|..:.|| |:||||:|:......::
Worm    70 ALKFKKPVAAEKWTEPRDCYEYGPGCPQTGRFAALTAKSTAAFAE-ENCLTLNVFAPRWKLAEFP 133

  Fly   140 ---PVMFYIYGGGFYNGSSEDHPPNYLLE-----KDVVLVVPQYRVGALGWLSTYTEELPGNAPI 196
               ||:.||||||:..|.: .:..:|.|.     |||::|...||:|.||:|:.......||..:
Worm   134 KGLPVLVYIYGGGYEIGFT-SYMDDYSLTGTLPLKDVIVVTMNYRLGPLGFLTIADGIANGNYGL 197

  Fly   197 ADILMALDWVQMHISSFGGDPQKVTIFGQSAGAGVASSLLLSPKTGDNMFKRAIVQSGSIFASWA 261
            .|..:||.|||.:|:||||:|:.||:.|.||||.....|.|||.: :.:|:|:|..||:.|.::|
Worm   198 WDQTLALQWVQDNIASFGGNPESVTLSGTSAGATSTDFLSLSPHS-NQLFQRSISMSGTAFCNFA 261

  Fly   262 INKDPKAQSRRICIQL----GCSGCEQHD----QLVKCIQKAKVIDILKATASESFSPIVGDLHG 318
            |.  ||.....:|.:.    |.:|.:...    .:.:.:.|.|.:...::||:.:. |.:.:..|
Worm   262 IR--PKDVEVGVCKEFAQFQGYTGTDSQSLFDWYMAQNVSKFKEVAGFQSTAAGAV-PFIPNFDG 323

  Fly   319 ILPQQPSELVKSYRRQIP----ILTGFTQHDGSFVLASYYDALAAKVANVSSLSVRQFSQGINDL 379
            ....:|.:::   ||:.|    ::|..|......::   ::.|.|...|           .....
Worm   324 DFFPKPFDIL---RREAPKKDALITVVTMESVGMII---FNPLFANAYN-----------NFEGF 371

  Fly   380 VNDTSG--LTD---NILNRLL-FKPQALNSHDHSAAVSSYFDLTTNIFMKSPVITLATKMYTQQR 438
            :|:|.|  :||   ::..:|. |..:.:|:.|.:.......|..::....|..:. |.|.|.:.
Worm   372 INETYGPDVTDYYADVKKKLTGFYLKDVNASDKATVNRRVVDYVSDSVFNSGTLD-AVKSYVKY- 434

  Fly   439 STPVYVYSFEYEGTYTRFGYEFGNSHYPFNGGVHHSNDNIYLFATHPLEG-QDTQMSQKMVD--- 499
            ...||:.||.|....|:...|.   ..||. ...||:|..|.|.:..:.. ..|....:::|
Worm   435 GNKVYLGSFNYFNDATKDMVEL---MQPFK-EASHSSDFKYYFGSGVMANFTPTDEEMEVMDMSG 495

  Fly   500 -VWTSFAIEGVPRNLSPLSSASGPYNKLNLEVTKGDDLLDTLTAAIDDP--------DNGRLQRE 555
             :..:|...|.|..    .|.:.|:....:       |...:...||.|        .||||:..
Worm   496 TLMANFVKYGDPNG----KSGTKPWKPYTI-------LKPNMYYKIDYPTCEMSDNFQNGRLRIY 549

  Fly   556 D 556
            |
Worm   550 D 550

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Est-Q	NP_649321.1	COesterase	39..544	CDD:278561	142/544 (26%)
Est-Q	NP_649321.1	Aes	<137..>240	CDD:223730	45/112 (40%)
cest-30	NP_504407.1	COesterase	31..539	CDD:278561	144/548 (26%)
cest-30	NP_504407.1	Aes	<122..>230	CDD:223730	41/108 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D206516at33208
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X33
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.820