Protein Alignment Est-Q and cest-16

DIOPT Version :9

• Sequence 1: NP_649321.1
• Gene: Est-Q / 40381
• FlyBaseID: FBgn0037090
• Length: 559
• Species: Drosophila melanogaster
• Sequence 2: NP_741812.2
• Gene: cest-16 / 180905
• WormBaseID: WBGene00020330
• Length: 697
• Species: Caenorhabditis elegans
• Alignment Length: 658
• Identity: 177/658 - (26%)
• Similarity: 266/658 - (40%)
• Gaps: 180/658 - (27%)

  Fly    20 LTAFLVIFLTGGQGADASETATVTVELYNGQGTVLGNYAYTAWTDRAFMQ-FRGIPFAEPPIEEL 83
            |...|....:...|....::.:|.||    ||.|.|| .|.  .|...:| |||:|:|||||.||
 Worm     4 LLLLLTFIFSWANGQLLEKSRSVWVE----QGLVRGN-IYN--IDGKHIQIFRGVPYAEPPIGEL 61

  Fly    84 RFRPPVARSPWTGTLNALNFGQRCPVI-----------TNLDSQMSDAELEDCLTLSVY----TK 133
            ||:|||.::.|...|.|:.:|..|...           ||:|.|.     ||||.|:|:    |.
 Worm    62 RFKPPVKKTRWHQELPAVEYGPPCLQFMDFHKNDKFAKTNMDRQS-----EDCLYLNVFSPYDTD 121

  Fly   134 NLSASQPVMFYIYGGGFYNGSSE-----DHPPNYLLEKDVVLVVPQYRVGALGWLSTYT-EELPG 192
            :.|.:.|::.:|:||.|..||::     :.....::.|.:..|...||:|.||:::... ::|.|
 Worm   122 DESKTYPILVWIHGGSFLAGSADTGIDMEVIAANIVSKGIAFVSINYRLGPLGFMNYQNGDKLEG 186

  Fly   193 NAPIADILMALDWVQMHISSFGGDPQKVTIFGQSAGAGVASSLLLSPKTGDNMFKRAIVQSGSIF 257
            |..|.|::|||.|:|.:|..|.|||.|||:.|:|||...:|.|.||||| ..:..:||:.|||..
 Worm   187 NFGIWDMVMALQWIQSNIKQFNGDPTKVTVMGESAGGAASSLLALSPKT-SGLLHQAIIMSGSSM 250

  Fly   258 ASWA-----------------------INKDPKAQ--------------SRRIC----IQLGC-- 279
            |.||                       ||:|...:              ...:|    :::.|
 Worm   251 AGWAIHRHSQPAYSVDNLVAYFRCEKWINEDDTKEVVGDEYQHLTHSVIRSALCNYQNVKINCLT 315

  Fly   280 SGCEQHDQLVKCIQKAKVID---ILKATASE---SFSPIVGDLHGILPQQPSELVKSYRRQIPIL 338
            ....|.|:: .|::|.....   ..||.|:|   |...:.|||   :|.....||::..| |||:
 Worm   316 DDMTQMDKM-NCLRKELNFSSPLFRKALAAELGVSKMVVDGDL---VPSSGVSLVRNNAR-IPIM 375

  Fly   339 TGFTQHDGSFVLASYY-----DALAAKVANVSSLSVRQFSQGIND-----LVNDTSGLTDNILNR 393
            ||..:.:.....|.:|     |.|  |.::|.....|......::     |.|.|..|..|
 Worm   376 TGVARKEWGHKKAMFYNMHQRDGL--KRSDVEEQVYRIIDNSFHETASEKLANSTVQLIAN---- 434

  Fly   394 LLFKPQALNSHDHSAAVSSYFDLTTNIFMKSPVITLATKMYTQ---------------QRSTPVY 443
                          |.:..|.:...|.|:...|:....|:.:.               .:..|||
 Worm   435 --------------ATIVRYLETPNNEFIADQVVGALQKLESDIEFVAPCEREVAAYVDKGVPVY 485

  Fly   444 VYSFEY----------EGTYTRFGYE------------------FGNSH-YPFNGGVHHSNDNIY 479
            :|||:|          ...|:.||.:                  .|..| :.|:.| :.||
 Worm   486 LYSFDYVPKSPILESERKIYSLFGTKPVEMKRTEKSEILEKAAFHGLDHAFIFSKG-YSSN---- 545

  Fly   480 LFATHPLEGQDTQMSQKMVDVWTSFAIEGVP---RNLSPL-SSASGPYNKLNLEVTKGDDLLDTL 540
             |...|...::..||:.:..:.|:|...|.|   |...|: |..|..|..|::.       |..|
 Worm   546 -FEISPYTKREETMSKILCTMLTNFVKNGDPSTTRFSWPIFSGNSSQYVSLDVP-------LKLL 602

  Fly   541 TAAIDDPD 548
            ...|..||
 Worm   603 EGEIHFPD 610

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Est-Q	NP_649321.1	COesterase	39..544	CDD:278561	171/633 (27%)
		Aes	<137..>240	CDD:223730	40/108 (37%)
cest-16	NP_741812.2	Abhydrolase	25..608	CDD:389770	172/633 (27%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X33
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.910