DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Est-Q and cest-24

DIOPT Version :9

Sequence 1:	NP_649321.1	Gene:	Est-Q / 40381	FlyBaseID:	FBgn0037090	Length:	559	Species:	Drosophila melanogaster
Sequence 2:	NP_504613.1	Gene:	cest-24 / 179017	WormBaseID:	WBGene00020891	Length:	658	Species:	Caenorhabditis elegans

Alignment Length:	542	Identity:	155/542 - (28%)
Similarity:	239/542 - (44%)	Gaps:	104/542 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 SETATVTVELYNGQGTVLGNYAYTAWTDRAFMQFRGIPFAEPPIEELRFRPPVARSPWTGTLNAL 101
            ||.|.|.|:    ||.:.|....||..|...: |.|||:||||:.||||:.|.....|.|.....
Worm    93 SENAIVRVQ----QGLLEGFRVKTAKGDLCDV-FHGIPYAEPPVGELRFQKPQPPKAWEGIRKCN 152

  Fly   102 NFGQRCPVITNLDSQM-------SDAELEDCLTLSVYTKNLSASQ--PVMFYIYGGGFYNGSSED 157
            .:..|     ::..:|       |..:.||||.|:|:...:...:  ||:|||:|||:...|:|.
Worm   153 KYPNR-----SIHKEMPWDKALPSANQSEDCLYLNVFAPKIREDKKYPVLFYIHGGGYVMDSAER 212

  Fly   158 HPP----NYLLEKDVVLVVPQYRVGALGWLSTYTEELPGNAPIADILMALDWVQMHISSFGGDPQ 218
            :..    ..|:.:::::|...||:|.||:|||..:..|||..:.|:|.|:.||..:||||||||:
Worm   213 YTAKNICKLLVSREIIVVTFHYRLGFLGFLSTGDDVCPGNYGLFDMLEAMRWVHANISSFGGDPE 277

  Fly   219 KVTIFGQSAGAGVASSLLLSPKTGDNMFKRAIVQSGSIFASWAI--NKDPKAQSRRICIQLGCSG 281
            .:|:.||||||..|..|..||.| ..:|||.||..|:.:..||.  |.|.:...::...:||..
Worm   278 NITLSGQSAGAAAADLLSFSPLT-KGLFKRKIVMGGNSYCHWATTSNHDIREYCKKWAKRLGWK- 340

  Fly   282 CEQHDQLVKCIQKAKVIDIL---------KATASESFS---------PIVGDLHG-ILPQQPSEL 327
                .||....::.:.:||.         |...:..||         |:...:.| |||.. .::
Worm   341 ----PQLNYANKREESVDIFNFFNGLPTSKLGMTMFFSNTIFKECQLPLAPVIDGEILPHD-LKV 400

  Fly   328 VKSYRRQIPILTGFTQHDGSFVLA------------SYYDALAAKVANVSSLSVRQFSQGINDLV 380
            ::..:..:|.|.|..:::.....|            |..|.|:.|    :.||..:.......:.
Worm   401 LRETQEHVPSLVGGGEYEALLFCAIGLLRGTEKEINSAIDVLSRK----NRLSRSKIEAMTEKVY 461

  Fly   381 NDTSGLTDNILNRLLFKPQALNSHDHSAAVSSYFDLTTNIFMKSPVITLATKMYTQQRSTPVYVY 445
            .|:..|..:...|.:|..|.::  |..|...:|      .||:.          .|||....|.|
Worm   462 GDSPALRADSKARKMFFVQLIS--DIFANYGNY------RFMRD----------CQQRGVECYGY 508

  Fly   446 SFEYEGTYTRFGYEFGNSH-YPFNGGVHHSN-----DNIYLFATHPLEGQDTQMSQKMVDVWTSF 504
            ||::: :...:|:   ..| .||.||.|.|.     |..|:.|...:...|..:|....|.:|:|
Worm   509 SFDHQ-SKQMWGW---LQHVVPFTGGTHTSELSYLFDCNYMSAPLGMNKTDKVVSGMTADYFTNF 569

  Fly   505 AIEGVPRNLSPLSSASGPYNKL 526
            ...|.|         :||.::|
Worm   570 VKFGTP---------NGPNSQL 582

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Est-Q	NP_649321.1	COesterase	39..544	CDD:278561	153/540 (28%)
Est-Q	NP_649321.1	Aes	<137..>240	CDD:223730	46/108 (43%)
cest-24	NP_504613.1	COesterase	97..608	CDD:278561	152/538 (28%)
cest-24	NP_504613.1	Aes	<183..>285	CDD:223730	39/101 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D206516at33208
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X33
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.920