DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Est-Q and cest-35.1

DIOPT Version :9

Sequence 1:	NP_649321.1	Gene:	Est-Q / 40381	FlyBaseID:	FBgn0037090	Length:	559	Species:	Drosophila melanogaster
Sequence 2:	NP_504400.1	Gene:	cest-35.1 / 178912	WormBaseID:	WBGene00015067	Length:	545	Species:	Caenorhabditis elegans

Alignment Length:	581	Identity:	161/581 - (27%)
Similarity:	234/581 - (40%)	Gaps:	120/581 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    45 ELYNGQ-GTVLGN-YAYTAWTDRAFMQFRGIPFAEPPIEELRFRPPVARSPWTGTLNALNFGQRC 107
            |:.|.. |.:.|| |.:   .|:....:.|||||:.||.||||:..|....||..|:...:|..|
Worm    15 EVLNASCGPIRGNIYEH---DDKIVDGYLGIPFAKAPIGELRFKKSVEAEKWTEPLDCYKYGPGC 76

  Fly   108 P-------VITNLDSQMSDAELEDCLTLSVYTKNLSASQ-----PVMFYIYGGGFYNGSS---ED 157
            |       :|....|.:.:...::||||:|:.....:::     ||:.|.|||||..|.|   :|
Worm    77 PQSGALGAMIVPQASAIREFAEDNCLTLNVFAPKWKSAEFPNGLPVIVYFYGGGFEVGFSSMFDD 141

  Fly   158 HPPNYLLE-KDVVLVVPQYRVGALGWLSTYTEELPGNAPIADILMALDWVQMHISSFGGDPQKVT 221
            :.....|. |||:||.|.||:|.||:.:|..:...||..:.|..:||.|||.||.||||||..||
Worm   142 YSLTGTLPLKDVILVTPNYRIGPLGFFATGDDVSRGNWGLWDQALALQWVQKHIKSFGGDPSNVT 206

  Fly   222 IFGQSAGAGVASSLLLSPKTGDNMFKRAIVQSGSIFASWAI-NKDPKAQ-SRRICIQLGCSGCEQ 284
            |.|.|||......|.|||. .:..|.:.|..||:....:.| :||.:.. .|......|.:| ..
Worm   207 ISGTSAGGASVDFLSLSPH-ANKYFHKFIPMSGAATCPFGIRSKDVEGLIFREFAKHHGYAG-ND 269

  Fly   285 HDQLVKCIQKAKVIDILKA-----TASESFSPIVGDLHGILPQQPSELVKSYRRQIPILTGFTQH 344
            .:.|:...|.......|||     .||..||.:........|:...||    |::.|.|
Worm   270 SESLLHWYQSQDAEIFLKAEGFKYPASGMFSFVPNYDGDFFPKPFDEL----RKEAPKL------ 324

  Fly   345 DGSFVLASYYDALAAKVANVSSLSVRQFSQGINDLVNDTSGLTDNILNRLLFKPQALNSHDH--S 407
                      ||:.: ||....|...:|..|...        ...:|...| .|:.:.:.:.  .
Worm   325 ----------DAIVS-VAEYEGLGFEEFYPGQKS--------PQEVLTAAL-GPEVVRNREEVVK 369

  Fly   408 AAVSSYFDLTTNIFMKS-----------------PVITLATKMYTQQRSTPVYVYSFEYEGTYTR 455
            .||.:|.:   ||..||                 .|....|.....:....||:.||.|....|.
Worm   370 KAVEAYLE---NIEDKSGEKIGKKLVEIFGDYYFSVGVFDTVRSLAKYGNNVYLSSFNYFNPETP 431

  Fly   456 FGYEFGNSHYPFNGGVHHSN------DNIYLFATHPLEGQDTQMSQKMVDVW----TSFAIEGVP 510
            .  .||.:. |||...|..:      |.|         |:.::..:|::|:.    |:||..|.|
Worm   432 I--MFGENR-PFNAASHGCDIRYILGDGI---------GEFSKEDRKVMDMMGTYLTNFAKYGNP 484

  Fly   511 RNLSPLSSASGPYNKLNLE------------VTKGDDLLDTLTAAIDDPDNGRLQREDMEF 559
            ..    ...|.|:.|.:|:            ....|:.||.....||:.:...:|.::|.|
Worm   485 NG----KGVSIPWEKYSLDNPGRYFKIDYPKCEMADNFLDGRYKIIDEVNEHGIQYQEMVF 541

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Est-Q	NP_649321.1	COesterase	39..544	CDD:278561	156/564 (28%)
Est-Q	NP_649321.1	Aes	<137..>240	CDD:223730	50/111 (45%)
cest-35.1	NP_504400.1	COesterase	14..516	CDD:278561	153/554 (28%)
cest-35.1	NP_504400.1	Aes	<106..>214	CDD:223730	47/107 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D206516at33208
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X33
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.820