DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Est-Q and ges-1

DIOPT Version :9

Sequence 1:	NP_649321.1	Gene:	Est-Q / 40381	FlyBaseID:	FBgn0037090	Length:	559	Species:	Drosophila melanogaster
Sequence 2:	NP_503411.1	Gene:	ges-1 / 178633	WormBaseID:	WBGene00001578	Length:	562	Species:	Caenorhabditis elegans

Alignment Length:	567	Identity:	154/567 - (27%)
Similarity:	248/567 - (43%)	Gaps:	126/567 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    70 FRGIPFAEPPIEELRFRPPVARSPWTGTLNALNFGQRCPVITNLDSQMSDAELEDCLTLSVYTKN 134
            |..||||:||:::|||..|||..||.....|..:...|.....|.:|.|....||||||::....
Worm    38 FLAIPFAKPPVDDLRFEKPVAPDPWEDVYPATQYRNDCTPHYRLVAQFSSYSGEDCLTLNIIKPK 102

  Fly   135 LSASQPVMFYIYGGGFYNGSSEDHPPNYLLEK----DVVLVVPQYRVGALGWLSTYTEELPGNAP 195
            .:...||:|:|:|||:..||:..|...:..::    .|::...|||:|.:|:.|..|.::.||..
Worm   103 KAEKLPVLFWIHGGGYEIGSASQHGYEFFAKRYASQGVIVATVQYRLGFMGFFSEGTSDVQGNWG 167

  Fly   196 IADILMALDWVQMHISSFGGDPQKVTIFGQSAGAGVASSLLLSPKTGDNMFKRAIVQSGSIFASW 260
            :.|...||::|:.:|.:|||||.::||:|.||||...|.|.:||.|.|: :.:||:.|.|.|..|
Worm   168 LFDQAAALEFVKSNIENFGGDPNQITIWGYSAGAASVSQLTMSPYTRDS-YSKAIIMSASSFVGW 231

  Fly   261 AINKDPKAQSRRICIQLGC--SGCEQHDQLVKCIQKAKV----------------IDILKATASE 307
            |...:....|:::...|||  .|.::      |::|..:                ||||:
Worm   232 ATGPNVVETSKQLAEILGCPWPGAKE------CMKKKSLHEIFDAIEVQGWTTGTIDILR----- 285

  Fly   308 SFSPIV-GDLHGILPQQPSELVKSYRRQIPILTGFTQHDGSFVLASYYDALAAKVANVSSLSVRQ 371
             :||:: ||   .:.:.|.||:|....: |.|.|.:..:|     ||:.||     |:..: :..
Worm   286 -WSPVIDGD---FMTKNPEELIKESPVK-PTLIGMSNKEG-----SYFAAL-----NMGRV-IAD 334

  Fly   372 FSQGINDLVN-DTSGLTDNILNRLLF-----------------------KP---QALNSHDHSAA 409
            |.....|:.. |...:::.|..:||:                       ||   :.||..    .
Worm   335 FGLSPEDMPKVDEEFISEIIGRKLLYNNRYGENREKVWNDILDFYVKQGKPAEVKDLNGF----Y 395

  Fly   410 VSSYFDLTTNIFMKSPVITLATKMYTQQRSTPVYVYSFEYEGTYTRFGYEFGNSHYPFNG-GVHH 473
            |..|.:|.::|....|::...|...  :|.|||:.|..::      :.......|.|... |..|
Worm   396 VDRYSELLSDITFNVPILREITSRV--ERKTPVWTYRMDH------YDKNIWKKHIPEQARGSPH 452

  Fly   474 SNDNIYLFATHPLEGQ-------DTQMSQKMVDVWTSFAIEGVPR----NLSPLSSASGPYNKLN 527
            :|:..||| ..|:..:       |:.:...::|:..|||..|||:    ...|:|... ..|.||
Worm   453 ANEYHYLF-DMPVMAKIDMKKEPDSWIQNDLIDMVISFAKTGVPQIEDVEWRPVSDPD-DVNFLN 515

  Fly   528 ----------------------LEVTKGDDLLDTLTAAIDDPDNGRL 552
                                  |...:|.||:|...:|:...:...|
Worm   516 IRSDGVSIEHGLFQEPLAFWNELRQREGFDLIDPTNSAMHSSNKDEL 562

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Est-Q	NP_649321.1	COesterase	39..544	CDD:278561	152/557 (27%)
Est-Q	NP_649321.1	Aes	<137..>240	CDD:223730	40/106 (38%)
ges-1	NP_503411.1	COesterase	18..535	CDD:278561	147/538 (27%)
ges-1	NP_503411.1	Aes	<100..>211	CDD:223730	39/110 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X33
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.810