DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Est-Q and Ces2c

DIOPT Version :9

Sequence 1:	NP_649321.1	Gene:	Est-Q / 40381	FlyBaseID:	FBgn0037090	Length:	559	Species:	Drosophila melanogaster
Sequence 2:	NP_598270.2	Gene:	Ces2c / 171118	RGDID:	621510	Length:	561	Species:	Rattus norvegicus

Alignment Length:	527	Identity:	143/527 - (27%)
Similarity:	235/527 - (44%)	Gaps:	61/527 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 LVIFLTGGQGADASETATVTVELYNGQGTVLGNYAYTAWTDRAFMQFRGIPFAEPPIEELRFRPP 88
            |::.|....|.|:.|::::.. .:.||  |.|...:...|......|.|||||:.|:..|||.||
  Rat    17 LLLILIHVWGQDSPESSSIRT-THTGQ--VRGKLDHVRDTKAGVHTFLGIPFAKAPVGPLRFAPP 78

  Fly    89 VARSPWTGTLNALNFGQRCPVITNLDS----QMSDAEL--------EDCLTLSVYT---KNLSAS 138
            ....||:|..:..:....|  :.|:|.    .::|.::        ||||.|::||   .:..::
  Rat    79 EDPEPWSGVRDGTSHPAMC--LQNIDMLDEVGLTDMKMILSSIPMSEDCLYLNIYTPAHAHEGSN 141

  Fly   139 QPVMFYIYGGGFYNGSSEDHPPNYL-LEKDVVLVVPQYRVGALGWLSTYTEELPGNAPIADILMA 202
            .|||..|:||....|.:.....:.| :.:|:|:|..|||:|.||:.||..|...||....|.:.|
  Rat   142 LPVMVCIHGGALVIGMASMCDGSLLAVNEDLVVVAIQYRLGVLGFFSTGDEHARGNWGYLDQVAA 206

  Fly   203 LDWVQMHISSFGGDPQKVTIFGQSAGAGVASSLLLSPKTGDNMFKRAIVQSGSIFASWAINKDPK 267
            |.|||.:|:.|||:|.:|||||.|||....||.::||.: ..:|..||::||.......|::..:
  Rat   207 LRWVQQNIAHFGGNPNRVTIFGVSAGGTSVSSHVISPMS-QGLFHGAIMESGVALLPDLISETSE 270

  Fly   268 AQSRRICIQLGCSGCEQHDQ--LVKCIQKAKVIDILKATASESFSPIVGDLHGILPQQPSELVKS 330
            ..|..:.   ..||||..|.  ||:|::.....:||.........|.|.| ...||:.|.||:.|
  Rat   271 TVSTTVA---KLSGCEATDSETLVRCLRAKSGAEILVINKVFKMIPAVVD-GEFLPRHPKELLAS 331

  Fly   331 YR-RQIPILTGFTQHDGSFVLASYYDALAAKVANVSSLSVRQFSQGINDLVNDTSG--LTDNILN 392
            .. ..:|.:.|        |....|......|...:.:......:.:..::.||:.  :......
  Rat   332 EDFHPVPSIIG--------VNTDEYCCTIPMVMGTAQIIKELSRENLQAVLKDTAAQMMLPPECG 388

  Fly   393 RLLFKPQALNSHDHSAAVSSYFDLTTNIFMKSPVITLATKMYTQQRSTPVYVYSFEYEGTYTRFG 457
            .||.:....|:.|.......|.::..:.....|.:.:|   :.|:...|||.|.|::..:|
  Rat   389 DLLMEEYMGNTDDPQTLQIQYAEMMGDFLFVIPALQVA---HFQRSHAPVYFYEFQHAPSY---- 446

  Fly   458 YEFGNSHYPFNGGVHHSNDNIYLFATH------PLEGQDTQMSQKMVDVWTSFAIEGVPRNLSPL 516
              |.|...| :....|:::..::|.:.      ....::..:|::|:..|.:||..|.|
  Rat   447 --FKNVRPP-HVKADHADEVPFVFGSFFWGIKVDFTEEEKLLSRRMMKYWANFARHGNP------ 502

  Fly   517 SSASGPY 523
            :|...||
  Rat   503 NSEGLPY 509

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Est-Q	NP_649321.1	COesterase	39..544	CDD:278561	138/512 (27%)
Est-Q	NP_649321.1	Aes	<137..>240	CDD:223730	44/103 (43%)
Ces2c	NP_598270.2	COesterase	32..540	CDD:395084	138/512 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D206516at33208
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.820