DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Est-Q and Ces1c

DIOPT Version :9

Sequence 1:	NP_649321.1	Gene:	Est-Q / 40381	FlyBaseID:	FBgn0037090	Length:	559	Species:	Drosophila melanogaster
Sequence 2:	NP_031980.2	Gene:	Ces1c / 13884	MGIID:	95420	Length:	554	Species:	Mus musculus

Alignment Length:	542	Identity:	152/542 - (28%)
Similarity:	256/542 - (47%)	Gaps:	89/542 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 VYVMLTLCGVLTAGLTAFLVIFLTGGQGADASETATVTVELYNGQGTVLGNYAYTAWTDRAFMQF 70
            |:..|.:|.:|...|...:|            :|.         ||.|||.|......::....|
Mouse     7 VWASLAVCPILGHSLLPPVV------------DTT---------QGKVLGKYISLEGFEQPVAVF 50

  Fly    71 RGIPFAEPPIEELRFRPPVARSPWTGTLNALNFGQRC-------PVITNLDSQMSDAEL------ 122
            .|:|||:||:..|||.||....||:...||.::...|       .:::::.|  ::.|:
Mouse    51 LGVPFAKPPLGSLRFAPPQPAEPWSFVKNATSYPPMCSQDAGWAKILSDMFS--TEKEILPLKIS 113

  Fly   123 EDCLTLSVY-----TKNLSASQPVMFYIYGGGFYNGSSEDHPPNYL---LEKDVVLVVPQYRVGA 179
            ||||.|::|     ||  |:..|||.:|:|||...|.:.  |.|.|   ..::||:|..|||:|.
Mouse   114 EDCLYLNIYSPADLTK--SSQLPVMVWIHGGGLVIGGAS--PYNGLALSAHENVVVVTIQYRLGI 174

  Fly   180 LGWLSTYTEELPGNAPIADILMALDWVQMHISSFGGDPQKVTIFGQSAGAGVASSLLLSPKTGDN 244
            .|..||..|..|||....|.|.||.|||.:|::|||:|..|||||:|:|....|.|:||| .|.:
Mouse   175 WGLFSTGDEHSPGNWAHLDQLAALRWVQDNIANFGGNPDSVTIFGESSGGISVSVLVLSP-LGKD 238

  Fly   245 MFKRAIVQSGSIFASWAINKDPKAQSRRICIQLGCSGCEQHDQLVKCIQKAKVIDILKATA---- 305
            :|.|||.:||.:..:....|:.:|.:..|.....|:.... ..:|:|:::....::|:.:.
Mouse   239 LFHRAISESGVVINTNVGKKNIQAVNEIIATLSQCNDTSS-AAMVQCLRQKTESELLEISGKLVQ 302

  Fly   306 -SESFSPIVGDLHGILPQQPSELV--KSYRRQIPILTGFTQHDGSFVLASYYDALAAK---VANV 364
             :.|.|.::..:  :||:.|.|::  ||: ..:|.:.||.:.:..:::......|..:   ....
Mouse   303 YNISLSTMIDGV--VLPKAPEEILAEKSF-NTVPYIVGFNKQEFGWIIPMMLQNLLPEGKMNEET 364

  Fly   365 SSLSVRQFSQGINDLVNDTSGLTDNILNRLLFKPQALNSHDHSAAVSS-YFDLTTNIFMKSPVIT 428
            :||.:|:|...:|        ::::::..::  .|.|...|..|..|. ..|:..:||...|.:.
Mouse   365 ASLLLRRFHSELN--------ISESMIPAVI--EQYLRGVDDPAKKSELILDMFGDIFFGIPAVL 419

  Fly   429 LATKMYTQQRSTPVYVYSFEYEGTYTRFGYEFGNSHYPFNGGVHHSNDNIYLFATHPL--EG--- 488
            |:..:.....||  |:|.|.|..:       |.:...|......|.::..::|.. ||  ||
Mouse   420 LSRSLRDAGVST--YMYEFRYRPS-------FVSDKRPQTVEGDHGDEIFFVFGA-PLLKEGASE 474

  Fly   489 QDTQMSQKMVDVWTSFAIEGVP 510
            ::|.:|:.::..|.:||..|.|
Mouse   475 EETNLSKMVMKFWANFARNGNP 496

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Est-Q	NP_649321.1	COesterase	39..544	CDD:278561	146/509 (29%)
Est-Q	NP_649321.1	Aes	<137..>240	CDD:223730	48/105 (46%)
Ces1c	NP_031980.2	Esterase_lipase	25..525	CDD:238191	147/524 (28%)
		Aes	<121..>234	CDD:223730	51/116 (44%)
		Prevents secretion from ER. /evidence=ECO:0000255	551..554
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D206516at33208
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.820