DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Est-Q and ache

DIOPT Version :9

Sequence 1:	NP_649321.1	Gene:	Est-Q / 40381	FlyBaseID:	FBgn0037090	Length:	559	Species:	Drosophila melanogaster
Sequence 2:	NP_571921.1	Gene:	ache / 114549	ZFINID:	ZDB-GENE-010906-1	Length:	634	Species:	Danio rerio

Alignment Length:	564	Identity:	171/564 - (30%)
Similarity:	251/564 - (44%)	Gaps:	108/564 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 LTAFLVIFLTGGQGADASETATVTVELYNGQGTVLGNYAYTAWTDRA-FMQFRGIPFAEPPIEEL 83
            |...|:.||.....|.|.....|...|...|||.|      ...||: .:.|.|||:|||||.:.
Zfish     9 LPTVLLTFLFHNCFAQAEPDLVVATRLGRVQGTRL------PVPDRSHVIAFLGIPYAEPPIGKR 67

  Fly    84 RFRPPVARSPWTGTLNALNFGQRC-----------PVIT--NLDSQMSDAELEDCLTLSVYT--- 132
            ||:....:.||.....|..|...|           |.|.  |.:..||    ||||.|:|:.
Zfish    68 RFKRAEPKKPWNNVFEAKEFSNACYQFVDTSYPGFPGIEMWNPNRVMS----EDCLYLNVWVPPT 128

  Fly   133 ---KNLSASQPVMFYIYGGGFYNGSS--EDHPPNYLLEKDVVLVVP-QYRVGALGWLS-TYTEEL 190
               :||:    ||.:|||||||:|||  :.:...||...:.|:||. .|||||.|:|: ..:.:.
Zfish   129 PRPQNLT----VMVWIYGGGFYSGSSSLDVYDGRYLAYTEKVVVVSMNYRVGAFGFLALNGSSDA 189

  Fly   191 PGNAPIADILMALDWVQMHISSFGGDPQKVTIFGQSAGAGVASSLLLSPKTGDNMFKRAIVQSGS 255
            |||..:.|..:||.|||.:|..|||:|::|||||:||||......:|||.:.. :|.|||:|||.
Zfish   190 PGNVGLYDQRLALQWVQENIHFFGGNPKQVTIFGESAGAASVGMHVLSPDSRP-LFTRAILQSGV 253

  Fly   256 IFASWA-INKDPKAQSRRICIQLG-CSGCE--QHDQLVKCIQK---AKVID----IL--KATASE 307
            ....|| :..|   ::||...:|| ..||.  ...:|:.|::.   .::||    :|  .:....
Zfish   254 PNTPWATVTFD---EARRRTTKLGKLVGCTWGNDTELIDCLRNKHPQELIDQEWQVLPWSSLFRF 315

  Fly   308 SFSPIVGDLHGILPQQPSELVKSYR-RQIPILTGFTQHDGSFVLASYYDALAAKVANVSSLSVRQ 371
            ||.|:|..:  ..|..|..::.|.. :...||.|..|.:||:.|  .|.|......|.|.:|...
Zfish   316 SFVPVVDGV--FFPDTPDAMISSGNFKYTQILLGVNQDEGSYFL--LYGAPGFSKDNESLISRED 376

  Fly   372 FSQGI-------NDLVNDTSGLTDNILNRLLFKPQALNSHDHSAAVSSYFDLTTNIFMKSPVITL 429
            |.:.:       ||:     ||...||....:..:. |...:..|:.   |:..:..:..|:...
Zfish   377 FLESVKMGVPHANDI-----GLEAVILQYTDWMDEN-NGQKNRDAMD---DIVGDQNVICPLQHF 432

  Fly   430 ATKMYTQQRSTPVYVYSFEYE------GTYTRFGYEFGNSH-----YPFNG-----------GVH 472
            | |.|.|..:  ::..|....      |.....||..||||     |.|:.           ||.
Zfish   433 A-KSYAQYAA--LHAQSSAAAPGTLGWGNSGPTGYNSGNSHGAVYLYLFDHRASNLAWPEWMGVI 494

  Fly   473 HSNDNIYLFATHPLE------GQDTQMSQKMVDVWTSFAIEGVP 510
            |..:..::|.. |||      .::.::|::::..|.:||..|.|
Zfish   495 HGYEIEFVFGL-PLEKRLNYTAEEEKLSRRIMRYWANFARTGNP 537

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Est-Q	NP_649321.1	COesterase	39..544	CDD:278561	165/545 (30%)
Est-Q	NP_649321.1	Aes	<137..>240	CDD:223730	49/106 (46%)
ache	NP_571921.1	COesterase	23..583	CDD:278561	167/550 (30%)
ache	NP_571921.1	AChE_tetra	598..631	CDD:285837
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.910