DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Est-Q and Ache

DIOPT Version :9

Sequence 1:	NP_649321.1	Gene:	Est-Q / 40381	FlyBaseID:	FBgn0037090	Length:	559	Species:	Drosophila melanogaster
Sequence 2:	XP_036020624.1	Gene:	Ache / 11423	MGIID:	87876	Length:	616	Species:	Mus musculus

Alignment Length:	584	Identity:	176/584 - (30%)
Similarity:	263/584 - (45%)	Gaps:	115/584 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 AFLVIFLT-----GGQGADASETATVTVELYNGQ----------GTVLGNYAYTAWTDRAFMQFR 71
            ||.::||.     ||..|:..|...:.|.:..||          |.|              ..|.
Mouse    14 AFPLLFLLLSLLGGGARAEGREDPQLLVRVRGGQLRGIRLKAPGGPV--------------SAFL 64

  Fly    72 GIPFAEPPIEELRFRPPVARSPWTGTLNALNFGQRC--------PVITNLDSQMSDAEL-EDCLT 127
            ||||||||:...||.||..:.||:|.|:|..|...|        |.....:....:.|| ||||.
Mouse    65 GIPFAEPPVGSRRFMPPEPKRPWSGVLDATTFQNVCYQYVDTLYPGFEGTEMWNPNRELSEDCLY 129

  Fly   128 LSVYT--KNLSASQPVMFYIYGGGFYNG--SSEDHPPNYLLE-KDVVLVVPQYRVGALGWLS-TY 186
            |:|:|  ...::..||:.:|||||||:|  |.:.:...:|.: :..|||...||||..|:|: ..
Mouse   130 LNVWTPYPRPASPTPVLIWIYGGGFYSGAASLDVYDGRFLAQVEGAVLVSMNYRVGTFGFLALPG 194

  Fly   187 TEELPGNAPIADILMALDWVQMHISSFGGDPQKVTIFGQSAG-AGVASSLLLSPKTGDNMFKRAI 250
            :.|.|||..:.|..:||.|||.:|::|||||..||:||:||| |.|...:|..|..  ::|.||:
Mouse   195 SREAPGNVGLLDQRLALQWVQENIAAFGGDPMSVTLFGESAGAASVGMHILSLPSR--SLFHRAV 257

  Fly   251 VQSGSIFASWAINKDPKAQSRRICIQ--LGC--SGCEQHD-QLVKCIQKAKVIDIL--------- 301
            :|||:....||.....:|:.|...:.  :||  .|...:| :|:.|::.....|::
Mouse   258 LQSGTPNGPWATVSAGEARRRATLLARLVGCPPGGAGGNDTELIACLRTRPAQDLVDHEWHVLPQ 322

  Fly   302 KATASESFSPIV-GDLHGILPQQPSELVKSYRRQ-IPILTGFTQHDGSFVLASYYDALAAKVANV 364
            ::....||.|:| ||   .|...|..|:.:...| :.:|.|..:.:||:.|.  |........|.
Mouse   323 ESIFRFSFVPVVDGD---FLSDTPEALINTGDFQDLQVLVGVVKDEGSYFLV--YGVPGFSKDNE 382

  Fly   365 SSLSVRQFSQGINDLVNDTSGLTDNILNRLLFKPQALNSHD--H-----SAAVSSYFDLTTNIFM 422
            |.:|..||..|:...|...|.|....:  :|.....|:..|  |     ||.|..:     |:.
Mouse   383 SLISRAQFLAGVRIGVPQASDLAAEAV--VLHYTDWLHPEDPTHLRDAMSAVVGDH-----NVV- 439

  Fly   423 KSPVITLATKMYTQQRSTPVYVYSFEYE-GTYTRFGYEFGNSHYPFNGGVHHSNDNIYLFATHPL 486
             .||..||.::..|  ...||.|.||:. .|.|          :|...||.|..:..::|.. ||
Mouse   440 -CPVAQLAGRLAAQ--GARVYAYIFEHRASTLT----------WPLWMGVPHGYEIEFIFGL-PL 490

  Fly   487 E------GQDTQMSQKMVDVWTSFAIEGVPRN--------LSPLSSASGPYNKLN---LEVTKG 533
            :      .::...:|:::..||:||..|.|.:        ..|.::|:..|..||   |||.:|
Mouse   491 DPSLNYTTEERIFAQRLMKYWTNFARTGDPNDPRDSKSPQWPPYTTAAQQYVSLNLKPLEVRRG 554

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Est-Q	NP_649321.1	COesterase	39..544	CDD:278561	168/562 (30%)
Est-Q	NP_649321.1	Aes	<137..>240	CDD:223730	47/107 (44%)
Ache	XP_036020624.1	COesterase	37..563	CDD:395084	168/561 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910