DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Est-Q and Ces1d

DIOPT Version :9

Sequence 1:	NP_649321.1	Gene:	Est-Q / 40381	FlyBaseID:	FBgn0037090	Length:	559	Species:	Drosophila melanogaster
Sequence 2:	NP_444430.2	Gene:	Ces1d / 104158	MGIID:	2148202	Length:	565	Species:	Mus musculus

Alignment Length:	569	Identity:	155/569 - (27%)
Similarity:	238/569 - (41%)	Gaps:	126/569 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 GVYVMLTLCGVLTAGLTAFLVIFLTGGQGADASETATVTVELYNGQGTVLGNYAYTAWTDRAFMQ 69
            |:|.::.|.   .|..||:         |..:|.....||     :|.|||.|.......:....
Mouse     2 GLYPLIWLS---LAACTAW---------GYPSSPPVVNTV-----KGKVLGKYVNLEGFTQPVAV 49

  Fly    70 FRGIPFAEPPIEELRFRPPVARSPWTGTLNALNFGQRC-----------PVITNLDSQMSDAELE 123
            |.|:|||:||:..|||.||....||:...|..::...|           .:.||....:.....|
Mouse    50 FLGVPFAKPPLGSLRFAPPQPAEPWSFVKNTTSYPPMCSQDAVGGQVLSELFTNRKENIPLQFSE 114

  Fly   124 DCLTLSVY-----TKNLSASQPVMFYIYGGGFYNGSSEDHPPNYL-LEKDVVLVVPQYRVGALGW 182
            |||.|::|     |||  :..|||.:|:|||...|.:..:....| ..::||:|..|||:|..|:
Mouse   115 DCLYLNIYTPADLTKN--SRLPVMVWIHGGGLVVGGASTYDGLALSAHENVVVVTIQYRLGIWGF 177

  Fly   183 LSTYTEELPGNAPIADILMALDWVQMHISSFGGDPQKVTIFGQSAGAGVASSLLLSPKTGDNMFK 247
            .||..|...||....|.:.||.|||.:|::|||:|..|||||:|||....|.|:||| ...|:|.
Mouse   178 FSTGDEHSRGNWGHLDQVAALRWVQDNIANFGGNPGSVTIFGESAGGFSVSVLVLSP-LAKNLFH 241

  Fly   248 RAIVQSGSIFASWAINKDPKAQSRRICIQLGCS--------GC---EQHDQLVKCIQKAKV--ID 299
            |||.:||....:..|..|.|..:..:....||.        .|   :..|:|::...|..:  :|
Mouse   242 RAISESGVSLTAALITTDVKPIAGLVATLSGCKTTTSAVMVHCLRQKTEDELLETSLKLNLFKLD 306

  Fly   300 IL-KATASESFSPIVGDLHG-ILPQQPSELV--KSY---------RRQ-----IPILTGFTQHDG 346
            :| ....|..|.|.|.|  | :||:.|.|::  ||:         .:|     ||.|.|:...:|
Mouse   307 LLGNPKESYPFLPTVID--GVVLPKAPEEILAEKSFSTVPYIVGINKQEFGWIIPTLMGYPLAEG 369

  Fly   347 SF-------VLASYYDALAAKVA-NVSSLSVRQFSQGINDLVNDTSGLTDNILNRLLFKPQALNS 403
            ..       :|...|..|  |:: |:..:...::..|.:||........|.:.:.:...|..:.|
Mouse   370 KLDQKTANSLLWKSYPTL--KISENMIPVVAEKYLGGTDDLTKKKDLFQDLMADVVFGVPSVIVS 432

  Fly   404 HDHSAAVSSYFDLTTNIFMKSPVITLATKMYTQQRSTPVYVYSFEYEGTYT---RFGYEFGNSHY 465
            ..|..|.:|                             .|:|.|||..::.   |.....|:
Mouse   433 RSHRDAGAS-----------------------------TYMYEFEYRPSFVSAMRPKAVIGD--- 465

  Fly   466 PFNGGVHHSNDNIYLFATHPLEG----QDTQMSQKMVDVWTSFAIEGVP 510
                   |.::...:|.:..|:.    ::|.:|:.::..|.:||..|.|
Mouse   466 -------HGDEIFSVFGSPFLKDGASEEETNLSKMVMKFWANFARNGNP 507

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Est-Q	NP_649321.1	COesterase	39..544	CDD:278561	147/535 (27%)
Est-Q	NP_649321.1	Aes	<137..>240	CDD:223730	45/103 (44%)
Ces1d	NP_444430.2	COesterase	24..545	CDD:278561	147/535 (27%)
		Aes	<121..>239	CDD:223730	50/120 (42%)
		Prevents secretion from ER. /evidence=ECO:0000255	562..565
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D206516at33208
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.820