DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Est-Q and ache

DIOPT Version :9

Sequence 1:	NP_649321.1	Gene:	Est-Q / 40381	FlyBaseID:	FBgn0037090	Length:	559	Species:	Drosophila melanogaster
Sequence 2:	XP_002940088.1	Gene:	ache / 100490673	XenbaseID:	XB-GENE-923160	Length:	600	Species:	Xenopus tropicalis

Alignment Length:	525	Identity:	155/525 - (29%)
Similarity:	234/525 - (44%)	Gaps:	107/525 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    70 FRGIPFAEPPIEELRFRPPVARSPWTGTLNALNFGQRC-------------PVITNLDSQMSDAE 121
            |.||||||||::::|||....:.|||...:|..:...|             ..:.|.:..||
Frog    53 FLGIPFAEPPVDKMRFRRSEPKKPWTDVWDATAYPNACYQYFDTLYPGFPGMEMWNPNRPMS--- 114

  Fly   122 LEDCLTLSVYTKNLSASQ-PVMFYIYGGGFYNGSS--EDHPPNYLLEKDVVLVVP-QYRVGALGW 182
             ||||.|:::..:...|. .||.:|||||||:|||  :.:...||...:.|:||. .|||||.|:
Frog   115 -EDCLYLNIWVPHPRPSNATVMVWIYGGGFYSGSSSLDVYDGRYLCHAENVIVVSMNYRVGAFGF 178

  Fly   183 LSTYTE---ELPGNAPIADILMALDWVQMHISSFGGDPQKVTIFGQSAGAGVASSLLLSPKTGDN 244
            | |.|.   :.|||..:.|..:||.|||.:|:.|||||:.|||||:||||......:|||.: .:
Frog   179 L-TLTPGSVDAPGNVGLFDQRLALQWVQDNIAFFGGDPRTVTIFGESAGAVSVGMHVLSPGS-HH 241

  Fly   245 MFKRAIVQSGSIFASWAINKDPKAQSRRICIQ--LGCSGCEQHDQLVKCI---QKAKVID----I 300
            :|.:|.:||||....||.....:|:.|...:.  |.|. .....:|:.|:   |..::||    :
Frog   242 LFSKAALQSGSPNTPWATITPQEARRRTELLGKFLDCR-MGNDTELLNCLRVKQPQELIDHEFSV 305

  Fly   301 LKATASESFSPIVGDLHGILPQQPSELVKSYR-RQIPILTGFTQHDGSFVLASYYDALAAKVANV 364
            |.|.:...|:.:........|:.|..|:...| :..|::.|..|::||:.|  .|.|......|.
Frog   306 LPAPSVFRFAFVPVPDADFFPEPPEILMNMGRFKPCPLIMGVNQNEGSYFL--LYGAPGFSKNNE 368

  Fly   365 SSLSVRQFSQGINDLVNDTSGLTDNILNRLLFKPQALNSHDHSAAVSSYFD-------------- 415
            |.::..:|..|:...|                 ||| |.....|.|..|.|
Frog   369 SLITREEFLGGVKMSV-----------------PQA-NDIALEAVVMQYTDWADEHAGVKNREAM 415

  Fly   416 --LTTNIFMKSPVITLATKMYTQQRSTPVYVYSFEYEGTYTRFGYEFGNSHYPFNGGVHHSNDNI 478
              |..:..:..|:...|.|:  .:....||.|.|::..:         |..:|...||.|..:..
Frog   416 DQLVGDHNVICPLTYFAGKV--AETGNRVYTYFFDHRAS---------NLAWPQWMGVPHGYEIE 469

  Fly   479 YLFATHPLEG------QDTQMSQKMVDVWTSFAIEGVPRNLS-------PLSSAS---------G 521
            ::|.. ||:.      |:..:|::|:..|.:||..|.|...:       ||.:||         .
Frog   470 FVFGL-PLDANLNYTPQEEALSRRMMRYWANFARTGDPNEGNDAHQPRWPLYTASEQRYMALNNK 533

  Fly   522 PYNKL 526
            ||.:|
Frog   534 PYQEL 538

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Est-Q	NP_649321.1	COesterase	39..544	CDD:278561	155/525 (30%)
Est-Q	NP_649321.1	Aes	<137..>240	CDD:223730	53/109 (49%)
ache	XP_002940088.1	COesterase	31..549	CDD:395084	155/525 (30%)
ache	XP_002940088.1	AChE_tetra	564..597	CDD:400834
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910