DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Est-Q and si:ch211-71n6.4

DIOPT Version :9

Sequence 1:	NP_649321.1	Gene:	Est-Q / 40381	FlyBaseID:	FBgn0037090	Length:	559	Species:	Drosophila melanogaster
Sequence 2:	XP_009292113.1	Gene:	si:ch211-71n6.4 / 100148657	ZFINID:	ZDB-GENE-091204-213	Length:	596	Species:	Danio rerio

Alignment Length:	560	Identity:	148/560 - (26%)
Similarity:	233/560 - (41%)	Gaps:	116/560 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 GVYVMLTLCGVLTAGLTAFLVIFLTGGQGADASETATVTVELYNGQGTVLGNYAYTAWTDRAFMQ 69
            ||..:|||.|.|     |::         |..|......|:...|       :.:..|.|.|: .
Zfish    51 GVIALLTLAGYL-----AYV---------AKTSPPRVAEVQTECG-------WLHGQWKDGAY-S 93

  Fly    70 FRGIPFAEPPIEELRFRPPV----ARSPWTGTLNALNFGQRCPVITNLDSQMSDAELEDCLTLSV 130
            |:|||:|.||::|||::||.    |...|.|..:|.:|...|..:..|.........||||.|||
Zfish    94 FKGIPYAVPPVDELRWKPPENLVDAGKCWEGKYDATHFRSICAQVQPLQKDGKVMGEEDCLHLSV 158

  Fly   131 YTKNLSASQ--PVMFYIYGGGFYNGSSED---HPPNYLLEK-DVVLVVPQYRVGALGW--LSTYT 187
            :|.:|..::  |||.:|:||..:..|.::   .|...|.|: .:|.|...||:.|.|:  |..:.
Zfish   159 WTPSLHPAKPLPVMVWIHGGYLHMLSGQEKGYSPTEELAERTQMVYVSLNYRLNAFGFMALEMFR 223

  Fly   188 EELP----GNAPIADILMALDWVQMHISSFGGDPQKVTIFGQSAGAGVASSLLLSPKTGDNMFKR 248
            |..|    ||....|.:.||.|||.:|..|||||.:|||||||:|.....:|::|| ....:|..
Zfish   224 EGSPTNSSGNYGFMDQIQALQWVQRNIHHFGGDPGRVTIFGQSSGGTSVWTLMMSP-LAKGLFHG 287

  Fly   249 AIVQSGSIFASWAI---NKDPKAQSRRICIQLGCSGCEQHDQLVKCIQKAKVIDILKATASESFS 310
            ||..|||...:.::   .||.....||       :||:  |.|  |:::..:..:|:|...:.:.
Zfish   288 AIDMSGSYVYNASLESAEKDNLEFLRR-------TGCK--DAL--CLRRLNIAQVLQAIPWQQYP 341

  Fly   311 ----------PIVGDLHG--------ILPQQPSELVKSYRRQ-----IPILTGFTQHDGSFVLAS 352
                      |:.|...|        :|...|.|   |:.::     :|.:.|.|:.:..|
Zfish   342 SWAADDLVDLPVKGVFVGPVAVIDGHVLEAPPFE---SWEKRGAFNDVPFVVGTTEQETDF---- 399

  Fly   353 YYDALAAKVANVSSLSVRQFSQGINDLVNDTSGLTDNILNRLLFKPQALNSHDHSAAVSS----- 412
                 .....|:|:.....:...:.   :..|...:|:.:      |||..::.||...:
Zfish   400 -----GPPYKNISAWIWEDYRWIVK---SKLSPFGENVTS------QALKLYNSSAPCPTSDRCP 450

  Fly   413 ---YFDLTTNIFMKSPVITLATKMYTQQRSTPVYVYSFEYEGTYTRFGYEFGNSHYPF-NGGVHH 473
               :..:.:::....|...||.:.....:| |||    .|..|||.......:|..|| :....|
Zfish   451 ERLFTTMVSDMKASCPRNDLAKRAAGALKS-PVY----RYLVTYTPSKQANPSSWLPFPSRFAFH 510

  Fly   474 SNDNIYLF-----ATHPLEGQDTQMSQKMVDVWTSFAIEG 508
            ..|::..|     |...|...|....:.:...:..||.||
Zfish   511 LLDSLAFFRGLEMALGTLSPADIDFQEMITKYFVYFAKEG 550

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Est-Q	NP_649321.1	COesterase	39..544	CDD:278561	138/526 (26%)
Est-Q	NP_649321.1	Aes	<137..>240	CDD:223730	43/114 (38%)
si:ch211-71n6.4	XP_009292113.1	Abhydrolase	75..559	CDD:304388	138/522 (26%)
si:ch211-71n6.4	XP_009292113.1	Aes	<158..>269	CDD:223730	43/110 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910