DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Est-Q and Ces1f

DIOPT Version :9

Sequence 1:	NP_649321.1	Gene:	Est-Q / 40381	FlyBaseID:	FBgn0037090	Length:	559	Species:	Drosophila melanogaster
Sequence 2:	NP_001096829.2	Gene:	Ces1f / 100125372	RGDID:	1642419	Length:	561	Species:	Rattus norvegicus

Alignment Length:	523	Identity:	139/523 - (26%)
Similarity:	236/523 - (45%)	Gaps:	107/523 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    50 QGTVLGNYAYTAWTDRAFMQFRGIPFAEPPIEELRFRPPVARSPWTGTLNALNF----------G 104
            :|.|||.|.......::...|.|:|||:||:..|||.||....||:...|...:          |
  Rat    30 KGKVLGKYVSLEGVTQSVAVFLGVPFAKPPLGSLRFAPPQPAEPWSFVKNTTTYPPMCSQDAAKG 94

  Fly   105 QRC-PVITNLDSQMSDAELEDCLTLSVY-----TKNLSASQPVMFYIYGGGFYNGSSEDHPPNYL 163
            ||. .::||...::.....||||.|::|     |||  :..|||.:|:|||...|.:..:....|
  Rat    95 QRMNDLLTNRKEKIHLEFSEDCLYLNIYTPADFTKN--SRLPVMVWIHGGGMTLGGASTYDGRVL 157

  Fly   164 -LEKDVVLVVPQYRVGALGWLSTYTEELPGNAPIADILMALDWVQMHISSFGGDPQKVTIFGQSA 227
             ..::||:|..|||:|..|:.||..|...||....|.:.||.|||.:|::|||||..|||||:||
  Rat   158 SAYENVVVVAIQYRLGIWGFFSTGDEHSRGNWGHLDQVAALHWVQDNIANFGGDPGSVTIFGESA 222

  Fly   228 GAGVASSLLLSPKTGDNMFKRAIVQSGSIFASWAINKDPKAQSRRICIQLGCSGCEQHDQ--LVK 290
            |....|.|:|||.| .|:|.|||.:||.:|....:.||.:..:::|.   ..:|||....  :|.
  Rat   223 GGFSVSVLVLSPLT-KNLFHRAISESGVVFLPGLLTKDVRPAAKQIA---DMAGCETTTSAIIVH 283

  Fly   291 CIQK---------AKVIDILKATA----SESF---SPIVGDLHGILPQQPSELV--KSYRRQIPI 337
            |:::         .|.::::|.::    .||:   |.:|.::  :||:.|.|::  |:: ..:|.
  Rat   284 CLRQKTEEELLEIMKKMNLIKLSSQRDNKESYHFLSTVVDNV--VLPKDPKEILAEKNF-NTVPY 345

  Fly   338 LTGFTQHDGSFVLASYYDALAAKV---------------------ANVSSLSVRQFSQGINDLVN 381
            :.|..:.:..::|.:....:.|.|                     .::..:::.::.:|.:|.:.
  Rat   346 IVGINKQECGWLLPTMMGFVPADVELDKKMAITLLEKFASLYGIPEDIIPVAIEKYRKGSDDSIK 410

  Fly   382 DTSGLTDNILNRLLFKPQALNSHDHSAAVSSYFDLTTNIFMKSPVITLATKMYTQQRSTPVYVYS 446
            ...|:...|.:.....|..:.|.||..|                             ..|.|:|.
  Rat   411 IRDGILAFIGDVSFSIPSVMVSRDHRDA-----------------------------GAPTYMYE 446

  Fly   447 FEYEGTYTRFGYEFGNSHYPFNGGVHHSNDNIYLFATHPLEG----QDTQMSQKMVDVWTSFAIE 507
            ::|..:       |.:...|.:....|::|...:|....|..    ::.::|:.::..|.:||..
  Rat   447 YQYYPS-------FSSPQRPKHVVGDHADDLYSVFGAPILRDGASEEEIKLSKMVMKFWANFARN 504

  Fly   508 GVP 510
            |.|
  Rat   505 GNP 507

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Est-Q	NP_649321.1	COesterase	39..544	CDD:278561	139/523 (27%)
Est-Q	NP_649321.1	Aes	<137..>240	CDD:223730	46/103 (45%)
Ces1f	NP_001096829.2	COesterase	24..545	CDD:278561	139/523 (27%)
		Aes	<121..>234	CDD:223730	49/114 (43%)
		Prevents secretion from ER. /evidence=ECO:0000255\|PROSITE-ProRule:PRU10138	558..561
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D206516at33208
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.820