DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment LRP4 and arr

DIOPT Version :9

Sequence 1:NP_002325.2 Gene:LRP4 / 4038 HGNCID:6696 Length:1905 Species:Homo sapiens
Sequence 2:NP_524737.2 Gene:arr / 44279 FlyBaseID:FBgn0000119 Length:1678 Species:Drosophila melanogaster


Alignment Length:1276 Identity:484/1276 - (37%)
Similarity:713/1276 - (55%) Gaps:80/1276 - (6%)


- Green bases have known domain annotations that are detailed below.


Human   442 LLFANRIDIRQVLPHR----SEYTLLLNNLENAIALDFHHRRELVFWSDVTLDRILRANLNGSNV 502
            |||..|.||:.....|    .:..:::.:|..|:|:||::.:.||.|:|...:.|..|..|.|.:
  Fly    89 LLFTTRHDIQVANITRPTGGPQIDVIVRDLAEAMAIDFYYAKNLVCWTDSGREIIECAQTNSSAL 153

Human   503 --------EEVVSTGLESPGGLAVDWVHDKLYWTDSGTSRIEVANLDGAHRKVLLWQNLEKPRAI 559
                    :.|:||||:.|.|||:||..||:||||...:|||||.|||.::|||.|.:|::|||:
  Fly   154 QPLLRAPKQTVISTGLDKPEGLAMDWYTDKIYWTDGEKNRIEVATLDGRYQKVLFWTDLDQPRAV 218

Human   560 ALHPMEGTIYWTDWGNTPRIEASSMDGS--GRRIIADTHLFWPNGLTIDYAGRRMYWVDAKHHVI 622
            |:.|....:.|||||..|:||.:||||.  .|..:...|:||||||.:|.....:||.|.|||.|
  Fly   219 AVVPARKLLIWTDWGEYPKIERASMDGDPLSRMTLVKEHVFWPNGLAVDLKNELIYWTDGKHHFI 283

Human   623 ERANLDGSHRKAVISQGLPHPFAITVFEDSLYWTDWHTKSINSANKFTGKNQEIIRNKLHFPMDI 687
            :...||||.|:.::: .|.:||::|.::|.||||||...|:|:.:..|.:.:|:| :....|..:
  Fly   284 DVMRLDGSSRRTIVN-NLKYPFSLTFYDDRLYWTDWQRGSLNALDLQTRELKELI-DTPKAPNSV 346

Human   688 HTLHPQRQPAGKNRCGDNNGGCTHLCL--PSGQNYTCACPTGFRKISSHACAQSLDKFLLFARRM 750
            ....|..||...|.|..|||.|:||||  .:.|.::||||||.:.||::.||....:.:...:|.
  Fly   347 RAWDPSLQPYEDNPCAHNNGNCSHLCLLATNSQGFSCACPTGVKLISANTCANGSQEMMFIVQRT 411

Human   751 DIRRISFDTEDLSDDVIPLADVRSAVALDWDSRDDHVYWTDVSTDTISRAKWDGTGQEVVVDTSL 815
            .|.:||.|:.|.:...:||..|:.|:|:|:|..::|:||:||.|.||.||..||||....|.:.:
  Fly   412 QISKISLDSPDYTIFPLPLGKVKYAIAIDYDPVEEHIYWSDVETYTIKRAHADGTGVTDFVTSEV 476

Human   816 ESPAGLAIDWVTNKLYWTDAGTDRIEVANTDGSMRTVLIWENLDRPRDIVVEPMGGYMYWTDWG- 879
            ..|.|||:||:...|||||..||||||...||:.|.|||:|:|:.||.|.|.|..|:|:|:||. 
  Fly   477 RHPDGLALDWLARNLYWTDTVTDRIEVCRLDGTARKVLIYEHLEEPRAIAVAPSLGWMFWSDWNE 541

Human   880 ASPKIERAGMDASGRQVIISSNLTWPNGLAIDYGSQRLYWADAGMKTIEFAGLDGSKRKVLIGSQ 944
            ..||:|||.:|.|.|.|::|.||.||||:|:|..::.:||.|.....||.|.:|||.|:|:|...
  Fly   542 RKPKVERASLDGSERVVLVSENLGWPNGIALDIEAKAIYWCDGKTDKIEVANMDGSGRRVVISDN 606

Human   945 LPHPFGLTLYGERIYWTDWQTKSIQSADRLTGLDRETLQENLENLMDIHVFHRRRPPVSTPCAME 1009
            |.|.|||::..:.:||||||.:||..|.::||.:|..:.:...:||.:.|...|.......||:.
  Fly   607 LKHLFGLSILDDYLYWTDWQRRSIDRAHKITGNNRIVVVDQYPDLMGLKVTRLREVRGQNACAVR 671

Human  1010 NGGCSHLCLRSPNPSGFSCTCPTGINLLSDGKTC-SPGMNSFLIFARRIDIRMVSLD-------- 1065
            |||||||||.  .|..:.|.|.....|.:|.:|| .|.  :||:|:|:..|..:|::        
  Fly   672 NGGCSHLCLN--RPRDYVCRCAIDYELANDKRTCVVPA--AFLLFSRQEHIGRISIEYNEGNHND 732

Human  1066 --IPYFADVVVPINITMKNTIAIGVDPQEGKVYWSDSTLHRISRANLDGSQHEDIITTGLQTTDG 1128
              || |.||        ::..|:.|...|.::||:|.....|.||.|:||..:.|:.:||...||
  Fly   733 ERIP-FKDV--------RDAHALDVSVAERRIYWTDQKSKCIFRAFLNGSYVQRIVDSGLIGPDG 788

Human  1129 LAVDAIGRKVYWTDTGTNRIEVGNLDGSMRKVLVWQNLDSPRAIVLYHEMGFMYWTDWGENAKLE 1193
            :|||.:...:||:|....||||..||||.|:||:|:.::.||::||....|:||||: .....:.
  Fly   789 IAVDWLANNIYWSDAEARRIEVARLDGSSRRVLLWKGVEEPRSLVLEPRRGYMYWTE-SPTDSIR 852

Human  1194 RSGMDGSDRAVLI--NNNLGWPNGLTVDKASSQLLWA-DAHTERIEAADLNGANRHTLV-SPVQH 1254
            |:.|||||...::  .|:..   |||.|:.:.:|.|| .:...:||:||.:|..|..|| |.:..
  Fly   853 RAAMDGSDLQTIVAGANHAA---GLTFDQETRRLYWATQSRPAKIESADWDGKKRQILVGSDMDE 914

Human  1255 PYGLTLLDSYIYWTDWQTRSIHRADKGTGSNVILVRSNLPGLMDMQAVDRAQPLGFNKCGSRNGG 1319
            ||.::|...|:||:||.|..|.|..|.||.|..||.|.:..:..:...:..:..|.|.|...|||
  Fly   915 PYAVSLYQDYVYWSDWNTGDIERVHKTTGQNRSLVHSGMTYITSLLVFNDKRQTGVNPCKVNNGG 979

Human  1320 CSHLCLPRPS--GFSCACPTGIQLKGDGKTCDPSPETYLLFSSRGSIRRISLDTSDHTDVHVPVP 1382
            ||||||.:|.  |.:|||||..||..||.:|.| |..|::||.|....|:..:|:|..::.:||.
  Fly   980 CSHLCLAQPGRRGMTCACPTHYQLAKDGVSCIP-PRNYIIFSQRNCFGRLLPNTTDCPNIPLPVS 1043

Human  1383 ELNNVISLDYDSVDGKVYYTDVFLDVIRRADLNGSNMETVIGRGLKTTDGLAVDWVARNLYWTDT 1447
            . .|:.::|||.:...:|:.:.....|:|:..||:.:..:...| :..| ||:|.:.|.|:||.:
  Fly  1044 G-KNIRAVDYDPITHHIYWIEGRSHSIKRSLANGTKVSLLANSG-QPFD-LAIDIIGRLLFWTCS 1105

Human  1448 GRNTIEASRLDGSCRKVLINNSLDEPRAIAVFPRKGYLFWTDWGHIAKIERANLDGSERKVLINT 1512
            ..|:|..:...|....|:.....::||.|||...|..|||||.|....|.||.:||:|| |.:..
  Fly  1106 QSNSINVTSFLGESVGVIDTGDSEKPRNIAVHAMKRLLFWTDVGSHQAIIRARVDGNER-VELAY 1169

Human  1513 DLGWPNGLTLDYDTRRIYWVDAHLDRIESADLNGKLRQVLVS-HVSHPFALTQQDRWIYWTDWQT 1576
            .|.....|.||..:..||:  ||..||::.|:|||.::.||| |:|....:.....::||.|.:|
  Fly  1170 KLEGVTALALDQQSDMIYY--AHGKRIDAIDINGKNKKTLVSMHISQVINIAALGGFVYWLDDKT 1232

Human  1577 KSIQRVDKYSGRNKETVLANVEGLMDIIVV-SPQRQTGTN-ACGVNNGGCTHLC------FARAS 1633
             .::|: ..:|..:...|..:..:.||..| :|..:...| .|..:...|:|:|      .||..
  Fly  1233 -GVERI-TVNGERRSAELQRLPQITDIRAVWTPDPKVLRNHTCMHSRTKCSHICIASGEGIARTR 1295

Human  1634 DFVCACPDE----PDSRPCSLVPGLVPP----APRATGMSE 1666
            | ||:||..    .|...|...|...|.    |...:|:|:
  Fly  1296 D-VCSCPKHLMLLEDKENCGAFPACGPDHFTCAAPVSGISD 1335

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LRP4NP_002325.2 LDLa 27..66 CDD:238060
Ldl_recept_a 70..105 CDD:278486
LDLa 110..142 CDD:238060
LDLa 148..182 CDD:238060
LDLa 231..265 CDD:238060
LDLa 270..304 CDD:238060
LDLa 311..343 CDD:197566
FXa_inhibition 358..393 CDD:291342
EGF_CA 395..434 CDD:214542
NHL <471..622 CDD:302697 73/160 (46%)
NHL repeat 471..507 CDD:271320 12/43 (28%)
LDL-receptor class B 1 480..522 19/49 (39%)
LY 505..545 CDD:214531 25/39 (64%)
NHL repeat 510..550 CDD:271320 24/39 (62%)
LDL-receptor class B 2 523..565 24/41 (59%)
NHL repeat 555..589 CDD:271320 17/35 (49%)
LDL-receptor class B 3 566..609 21/44 (48%)
LY 590..632 CDD:214531 19/41 (46%)
NHL repeat 598..622 CDD:271320 13/23 (57%)
LDL-receptor class B 4 610..652 16/41 (39%)
LY 633..673 CDD:214531 14/39 (36%)
LDL-receptor class B 5 653..693 12/39 (31%)
FXa_inhibition 702..>729 CDD:291342 16/28 (57%)
LY 766..806 CDD:214531 19/39 (49%)
LDL-receptor class B 6 785..827 21/41 (51%)
LY 808..850 CDD:214531 20/41 (49%)
LDL-receptor class B 7 828..870 24/41 (59%)
LDL-receptor class B 8 871..914 23/43 (53%)
Ldl_recept_b 871..911 CDD:278487 22/40 (55%)
LY 895..937 CDD:214531 19/41 (46%)
LDL-receptor class B 9 915..956 17/40 (43%)
LY 938..979 CDD:214531 18/40 (45%)
LDL-receptor class B 10 957..998 15/40 (38%)
FXa_inhibition 1006..1043 CDD:291342 16/36 (44%)
NHL <1085..1277 CDD:302697 77/195 (39%)
NHL repeat 1085..1123 CDD:271320 13/37 (35%)
LDL-receptor class B 11 1093..1135 17/41 (41%)
NHL repeat 1128..1161 CDD:271320 16/32 (50%)
LDL-receptor class B 12 1136..1178 19/41 (46%)
NHL repeat 1166..1203 CDD:271320 15/36 (42%)
LDL-receptor class B 13 1179..1222 16/44 (36%)
Ldl_recept_b 1179..1219 CDD:278487 15/41 (37%)
NHL repeat 1212..1244 CDD:271320 12/32 (38%)
LDL-receptor class B 14 1223..1263 15/41 (37%)
NHL repeat 1253..1277 CDD:271320 10/23 (43%)
LDL-receptor class B 15 1264..1306 15/41 (37%)
FXa_inhibition 1313..1348 CDD:291342 21/36 (58%)
LY 1379..1418 CDD:214531 11/38 (29%)
LDL-receptor class B 16 1397..1439 10/41 (24%)
LY 1420..1460 CDD:214531 11/39 (28%)
LDL-receptor class B 17 1440..1482 13/41 (32%)
LDL-receptor class B 18 1483..1526 18/42 (43%)
Ldl_recept_b 1483..1523 CDD:278487 16/39 (41%)
LY 1507..1547 CDD:214531 13/39 (33%)
LDL-receptor class B 19 1527..1568 15/41 (37%)
LY 1549..1589 CDD:214531 11/40 (28%)
LDL-receptor class B 20 1569..1610 11/41 (27%)
FXa_inhibition 1617..>1641 CDD:291342 10/29 (34%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1659..1686 2/8 (25%)
Endocytosis signal. /evidence=ECO:0000255 1766..1769
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1852..1905
arrNP_524737.2 LY 162..201 CDD:214531 23/38 (61%)
NHL 168..503 CDD:302697 149/336 (44%)
NHL repeat 172..237 CDD:271320 35/64 (55%)
LY 252..293 CDD:214531 19/40 (48%)
NHL repeat 261..298 CDD:271320 17/36 (47%)
NHL repeat 303..339 CDD:271320 15/36 (42%)
NHL repeat 341..419 CDD:271320 29/77 (38%)
NHL repeat 428..476 CDD:271320 22/47 (47%)
LY 472..511 CDD:214531 20/38 (53%)
NHL repeat 477..503 CDD:271320 15/25 (60%)
Ldl_recept_b 534..573 CDD:278487 21/38 (55%)
LY 558..599 CDD:214531 19/40 (48%)
LY 600..641 CDD:214531 18/40 (45%)
FXa_inhibition 668..703 CDD:291342 16/36 (44%)
LY 739..773 CDD:214531 12/41 (29%)
LY 776..818 CDD:214531 19/41 (46%)
LY 819..860 CDD:214531 16/41 (39%)
FXa_inhibition 973..1010 CDD:291342 21/36 (58%)
LY 1122..1164 CDD:214531 18/41 (44%)
FXa_inhibition 1273..1313 CDD:291342 12/40 (30%)
LDLa 1319..1362 CDD:238060 4/17 (24%)
LDLa 1365..1399 CDD:238060
LDLa 1399..1433 CDD:197566
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165155341
Domainoid 1 1.000 104 1.000 Domainoid score I6713
eggNOG 1 0.900 - - E1_KOG1215
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D121310at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100345
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
76.650

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