DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment LRP4 and yl

DIOPT Version :9

Sequence 1:NP_002325.2 Gene:LRP4 / 4038 HGNCID:6696 Length:1905 Species:Homo sapiens
Sequence 2:NP_996433.1 Gene:yl / 32367 FlyBaseID:FBgn0004649 Length:1984 Species:Drosophila melanogaster


Alignment Length:1957 Identity:491/1957 - (25%)
Similarity:772/1957 - (39%) Gaps:515/1957 - (26%)


- Green bases have known domain annotations that are detailed below.


Human   135 CG-------DNSDEQCDMRKCSDKEFRCSDGSCIAEHWYCDGDTDCKDGSDEENCPSAVPAPPCN 192
            ||       .::|.:||.     .:|:|.||.||.:...|||..||||.|||.:|...:..||  
  Fly    75 CGGTAAGTPGSADTRCDA-----GQFQCRDGGCILQAKMCDGRGDCKDSSDELDCDYRLCRPP-- 132

Human   193 LEEFQCA--YGRCILDIYHCDGDDDCGDWSDESDC----------SSH--QPCRSGEFMCDSG-L 242
             ..|.||  :|.|:.....|:|.|:|....||.:|          ::|  :.|...||||... .
  Fly   133 -HWFPCAQPHGACLAAELMCNGIDNCPGGEDELNCPVRPGFRFGDTAHRMRSCSKYEFMCQQDRT 196

Human   243 CINAGWRCDGDADCDDQSDE-RNCTTS--MCTAEQFRCHSGRCV-RLSWRCDGEDDCADNSDEEN 303
            ||...:.|||..||.|:||| ..|..:  .|..|...|.:|||: |..|.|||.|||.|.|||..
  Fly   197 CIPIDFMCDGRPDCTDKSDEVAGCKQAEITCPGEGHLCANGRCLRRKQWVCDGVDDCGDGSDERG 261

Human   304 CENTGSPQCALDQFLCWNGR-CIGQRKLCNGVNDCGDNSDESPQQNCRPRTGEENCNVNNGGCAQ 367
            |.|...||  ..:|||.|.. |:...::|:|.:||.|.|||:...:.:|     :|:........
  Fly   262 CLNLCEPQ--KGKFLCRNRETCLTLSEVCDGHSDCSDGSDETDLCHSKP-----DCDAKKCALGA 319

Human   368 KCQMV-RGAVQCTCHTGYRLTEDGHTCQDVNECAE-EGYCSQGCTNSEGAFQCWCETGYELRPDR 430
            ||.|: ....:|.|..|:||.:....|:||:||.| :..|||||.|:.|.::|.|:.||.|..|.
  Fly   320 KCHMMPASGAECFCPKGFRLAKFEDKCEDVDECKEQDDLCSQGCENTSGGYRCVCDAGYLLDKDN 384

Human   431 RSCKAL-----GPEPVLLFANRIDIRQVLPH------RSEYTLLLNNLENAI--ALDFHHRRELV 482
            |:|:|:     ..:|:||:..::.|..:  |      |:....:..||...|  |.|..|    :
  Fly   385 RTCRAVVYGSKEQQPLLLYTTQMTIMGM--HLREDNVRNHVYQVAGNLSKVIGVAYDGSH----I 443

Human   483 FWSDV--TLDRILRANLNGSNVEEVVSTGLESPGGLAVDWVHDKLYWTDSGTSRIEVANLDGAHR 545
            :|:::  ..:.|::||.:|||.|.::::||::|..|||||:...:|::|:....|.|.:.||.:.
  Fly   444 YWTNIQNEAESIVKANGDGSNAEILLTSGLDAPEDLAVDWLTQNIYFSDNIMRHIAVCSNDGLNC 508

Human   546 KVLLWQNLEKPRAIALHPMEGTIYWTDWGNTPRIEASSMDGSGRRIIADTHLFWPNGLTIDYAGR 610
            .||:.|::.:||::|:.|.:|.::|||||..|.|..:|||||..|.|...::.||||:.:|...:
  Fly   509 AVLVTQDVHQPRSLAVWPQKGLMFWTDWGEKPMIGRASMDGSRSRPIVSDNIEWPNGIALDMHQQ 573

Human   611 RMYWVDAKHHVIERANLDGSHRKAVISQGLPHPFAITVFEDSLYWTDWHTKSINSANKFTGKNQE 675
            |:||||||...::....||:.|:.|:...|.||:.:.:|||.|||:||.|||:::.:||:||:..
  Fly   574 RIYWVDAKLGSVQTVRPDGTGRRTVLDGMLKHPYGLAIFEDQLYWSDWATKSVHACHKFSGKDHR 638

Human   676 II-RNKLHFPMDIHTLHPQRQPAGKNRCGDNNGGCTHLCL---PSGQNYTCACPTGFRKISSHAC 736
            |: :::..:.  :|..||.:||...:.|  .|..|:||||   |....::||||.|.|....|..
  Fly   639 ILAKDRTIYA--VHIYHPAKQPNSPHGC--ENATCSHLCLLAEPEIGGHSCACPDGMRLAPDHRR 699

Human   737 AQSLDK----FL-LFARRMDIRRISFDTEDLS---------DDVIPLADVRSAVALDWDSRDDHV 787
            ...::|    |: |....::|...:|....:|         ::::......|.:..|.|.|    
  Fly   700 CMLMEKRQRLFIGLGQVLLEIEHTAFGRHQVSKSYTLPCLINEMVYNRINGSLIIADNDQR---- 760

Human   788 YWTDVSTDTISRAKWDGTGQEVVVDTSLESPAGLAIDWVTNKLYWTDAGTDRIEVANTDGSMRTV 852
                    .|...:.:.....|:|.::|.:.:.||.|.::..|||.|.....|||.:.....|.:
  Fly   761 --------LILEFQPESHESNVLVRSNLGNVSALAFDHLSRNLYWADTERAVIEVLSLQTRHRAL 817

Human   853 L-IWENLDRPRDIVVEPMGGYMYWTDWGASPK----IERAGMDASGRQVIISSNLTWPNG--LAI 910
            : .:...:.|..:.|.|..||:|..   ...|    |::..:...|.||.:..:....:.  |..
  Fly   818 IRFFPGQEVPIGLTVMPAEGYLYVV---LKAKRHSHIDKIPLSGKGEQVHVFEDDLGDDDIKLVT 879

Human   911 DYGSQRLYWADAGMKTIEFAGLDGSKRKVLIGSQLPHPFGLTLYGERIYWTDWQTKSIQSADRLT 975
            ||.:|.::|:|:.:..|.::.......::..| :|..|:.|.:....::|.:..|..|.      
  Fly   880 DYETQTIFWSDSDLGRISYSNYRVPHSQIFRG-KLRRPYSLAMVHHDLFWNELGTPRIY------ 937

Human   976 GLDRETLQENLENLMDIHVFHRRRP-------PVST-----------------PCAMENGGCSHL 1016
                .|.:.|:.....|.:..:..|       ||:|                 ||..:||||||:
  Fly   938 ----WTHKSNMGPRKVIDIMEKDDPAAIMPYVPVATPNGIPLAASSPVGQESHPCQQQNGGCSHI 998

Human  1017 CLRSPNPSGFSCTCPTGINLLSDG-KTCSPGMN--------SFLIFARRIDIRMVSLDIPYFADV 1072
            |: ...|....|.||.|......| :||...::        ..|....|.:.|...:|       
  Fly   999 CV-GEGPYHSICLCPAGFVYRDAGNRTCVEALDCEFRCHSGECLTMNHRCNGRRDCVD------- 1055

Human  1073 VVPINITMKNTIAIGVD------------PQEGKVYWSDSTLHRISRAN--LDGSQHED------ 1117
                     |:..:..|            |.:...:..:..:.:..|.:  .|...|.|      
  Fly  1056 ---------NSDEMNCDEEHRRKPKVLCSPNQFACHSGEQCVDKERRCDNRKDCHDHSDEQHCEK 1111

Human  1118 -----------------------IITTGL----QTTDGLAVDAIGR---KVYWTDTGT------- 1145
                                   ::..|.    ..:|.|..:|..|   .::...:|:       
  Fly  1112 FDKSKKCHVHQHGCDNGKCVDSSLVCDGTNDCGDNSDELLCEATSRCEPGMFQCGSGSCIAGSWE 1176

Human  1146 --NRIEVGNLDGS--------------MRKVLVWQNLDSPRAIVLYHEMGFMYWTDWGENAKLER 1194
              .||:..  |||              |::.|:.|.||  |::|                     
  Fly  1177 CDGRIDCS--DGSDEHDKCVHRSCPPDMQRCLLGQCLD--RSLV--------------------- 1216

Human  1195 SGMDGSDRAVLINNNLGWPNGLTVDKASSQLLWADAHTERIEAAD------------------LN 1241
              .||       :|:.|       ||:.......|:.|..|..|:                  .|
  Fly  1217 --CDG-------HNDCG-------DKSDELNCGTDSSTMNISCAEDQYQCTSNLKICLPSTVRCN 1265

Human  1242 GANRHTLVSPVQHPYGLTLLD----SYIYWTDWQTRS----IHR-------ADKGTGSNVILV-- 1289
            |.        .:.|.|....|    ..||  :::.||    |.|       .|.|.||:.:..  
  Fly  1266 GT--------TECPRGEDEADCGDVCSIY--EFKCRSGRECIRREFRCDGQKDCGDGSDELSCEL 1320

Human  1290 -----------------RSNLPGLMDMQ---AVDRAQ---------------PLGFNKCGSRNGG 1319
                             ||..|.|.|.|   .||.::               |.....|.|.:|.
  Fly  1321 EKGHHNQSQIQPWSTSSRSCRPHLFDCQDGECVDLSRVCNNFPDCTNGHDEGPKCATACRSASGR 1385

Human  1320 --CSHLCLPRPSGFSCACPTGIQLKGDGKTC---DPSPE-------------------------- 1353
              |.|.|...|:|..|:|..|.:|..|.|:|   |...|                          
  Fly  1386 QVCQHKCRATPAGAVCSCFDGYRLDADQKSCLDIDECQEQQPCAQLCENTLGGYQCQCHADFMLR 1450

Human  1354 ------------TYLLFSSRGSIRRIS-----LDTS-DHTDVHVPVPELNNVISLDYDSV--DGK 1398
                        ..|||||...:|.:|     |:.: ...|..:...:|.....:.|.|.  :|.
  Fly  1451 QDRVSCKSLQSGATLLFSSFNEVRNLSEQPVMLNVAWSANDSRITGFDLAMHRQMGYFSAEDEGI 1515

Human  1399 VYYTDVFLDVIRRADLNGSNMETVIGRGLKTTDGLAVDWVARNLYWTDTGRNTIEASRLDG-SCR 1462
            ||..|:...||.||            .||.....|:||||..|:| ..:|...|:|....| .|.
  Fly  1516 VYQIDLQTKVIVRA------------LGLPAPTKLSVDWVTGNVY-VLSGAQEIQACSFVGRMCG 1567

Human  1463 KVLINNSLDEPRAIAVFPRKGY---LFW-----TDWGHI-AKIERANLDGSERKVLINTDLGWPN 1518
            :::   .:..||.:......||   :|:     ..:|.. ::|..|.||||.|.:|:.....:..
  Fly  1568 RIV---HVKSPRHVKHLAVDGYHARIFYIVIRTEGYGQTSSEIHMARLDGSRRDMLLQRSESFMT 1629

Human  1519 GLTLDYDTRRIYWVDAH---LDRIESADLNGKLRQVLV-----SHVSHPFALTQQDRWIYWTDWQ 1575
            .||.|...:.:|:||.|   |:||......|.:|:..:     :.:.||..|:..:...:..:..
  Fly  1630 ALTTDPHQQLLYFVDQHMRTLERISYRLKTGPMRRPEIMLQKSNALMHPSGLSVYENNAFIVNLG 1694

Human  1576 TKSIQRVDKYSGRNKETVLANVEGLMDIIVV--SPQRQTGTNACGVNNGGCTHLCFARASDFVCA 1638
            :....:...|..|....:..||....||:|.  |.|.|..::.|.  :..|..||......:.|.
  Fly  1695 SVEAVQCALYGSRICHKISINVLNAQDIVVAGRSRQPQKASHPCA--HAHCHGLCLQADYGYECM 1757

Human  1639 CPDEPDSRPCSLVPGLVPPAPRATGMSEKSPVLPNTPPTTLYSSTTRTRTSLEEVEGRCSERDAR 1703
            |.:                  |.....|:.|                 ..|..||        |.
  Fly  1758 CGN------------------RLVAEGERCP-----------------HGSGNEV--------AV 1779

Human  1704 LGLCARSNDAVPAAPGEGLHISYAIGGLLSILLILVVIAA--------LMLYRHKKSKFTDPGMG 1760
            ||       ||.:...|..|..   .|....|:.|.|:||        .|.|::::...||..: 
  Fly  1780 LG-------AVNSLELEHEHEQ---NGHFHWLMALFVLAAGSLIAGLGYMYYQYRQRGHTDLNI- 1833

Human  1761 NLTYSNP 1767
            |:.:.||
  Fly  1834 NMHFQNP 1840

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LRP4NP_002325.2 LDLa 27..66 CDD:238060
Ldl_recept_a 70..105 CDD:278486
LDLa 110..142 CDD:238060 3/13 (23%)
LDLa 148..182 CDD:238060 16/33 (48%)
LDLa 231..265 CDD:238060 16/35 (46%)
LDLa 270..304 CDD:238060 18/34 (53%)
LDLa 311..343 CDD:197566 12/32 (38%)
FXa_inhibition 358..393 CDD:291342 9/35 (26%)
EGF_CA 395..434 CDD:214542 19/39 (49%)
NHL <471..622 CDD:302697 60/154 (39%)
NHL repeat 471..507 CDD:271320 12/39 (31%)
LDL-receptor class B 1 480..522 16/43 (37%)
LY 505..545 CDD:214531 14/39 (36%)
NHL repeat 510..550 CDD:271320 15/39 (38%)
LDL-receptor class B 2 523..565 13/41 (32%)
NHL repeat 555..589 CDD:271320 17/33 (52%)
LDL-receptor class B 3 566..609 20/42 (48%)
LY 590..632 CDD:214531 16/41 (39%)
NHL repeat 598..622 CDD:271320 12/23 (52%)
LDL-receptor class B 4 610..652 16/41 (39%)
LY 633..673 CDD:214531 18/39 (46%)
LDL-receptor class B 5 653..693 15/40 (38%)
FXa_inhibition 702..>729 CDD:291342 13/29 (45%)
LY 766..806 CDD:214531 5/39 (13%)
LDL-receptor class B 6 785..827 7/41 (17%)
LY 808..850 CDD:214531 13/41 (32%)
LDL-receptor class B 7 828..870 11/42 (26%)
LDL-receptor class B 8 871..914 11/48 (23%)
Ldl_recept_b 871..911 CDD:278487 9/45 (20%)
LY 895..937 CDD:214531 9/43 (21%)
LDL-receptor class B 9 915..956 8/40 (20%)
LY 938..979 CDD:214531 7/40 (18%)
LDL-receptor class B 10 957..998 6/40 (15%)
FXa_inhibition 1006..1043 CDD:291342 14/37 (38%)
NHL <1085..1277 CDD:302697 44/290 (15%)
NHL repeat 1085..1123 CDD:271320 6/80 (8%)
LDL-receptor class B 11 1093..1135 8/76 (11%)
NHL repeat 1128..1161 CDD:271320 10/58 (17%)
LDL-receptor class B 12 1136..1178 14/67 (21%)
NHL repeat 1166..1203 CDD:271320 6/36 (17%)
LDL-receptor class B 13 1179..1222 6/42 (14%)
Ldl_recept_b 1179..1219 CDD:278487 4/39 (10%)
NHL repeat 1212..1244 CDD:271320 8/49 (16%)
LDL-receptor class B 14 1223..1263 9/61 (15%)
NHL repeat 1253..1277 CDD:271320 8/31 (26%)
LDL-receptor class B 15 1264..1306 18/74 (24%)
FXa_inhibition 1313..1348 CDD:291342 14/36 (39%)
LY 1379..1418 CDD:214531 11/40 (28%)
LDL-receptor class B 16 1397..1439 14/41 (34%)
LY 1420..1460 CDD:214531 13/40 (33%)
LDL-receptor class B 17 1440..1482 9/42 (21%)
LDL-receptor class B 18 1483..1526 15/51 (29%)
Ldl_recept_b 1483..1523 CDD:278487 14/48 (29%)
LY 1507..1547 CDD:214531 11/42 (26%)
LDL-receptor class B 19 1527..1568 12/48 (25%)
LY 1549..1589 CDD:214531 5/44 (11%)
LDL-receptor class B 20 1569..1610 8/42 (19%)
FXa_inhibition 1617..>1641 CDD:291342 6/23 (26%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1659..1686 3/26 (12%)
Endocytosis signal. /evidence=ECO:0000255 1766..1769 2/2 (100%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1852..1905
ylNP_996433.1 LDLa 90..124 CDD:238060 18/38 (47%)
LDLa 131..166 CDD:238060 13/37 (35%)
LDLa 184..216 CDD:238060 14/31 (45%)
LDLa 227..262 CDD:238060 18/34 (53%)
LDLa 271..302 CDD:238060 13/30 (43%)
FXa_inhibition 352..387 CDD:291342 16/34 (47%)
Ldl_recept_b 442..482 CDD:278487 14/43 (33%)
LY 466..508 CDD:214531 15/41 (37%)
Ldl_recept_b 529..569 CDD:278487 19/39 (49%)
LY 553..595 CDD:214531 16/41 (39%)
LY 596..637 CDD:214531 19/40 (48%)
FXa_inhibition 669..700 CDD:291342 13/30 (43%)
LY 774..815 CDD:214531 13/40 (33%)
LDLa 1032..1062 CDD:238060 5/45 (11%)
LDLa 1074..1109 CDD:238060 5/34 (15%)
LDLa 1118..1152 CDD:238060 3/33 (9%)
LDLa 1157..1189 CDD:197566 7/33 (21%)
LDLa 1198..1232 CDD:238060 13/72 (18%)
LDLa 1243..1279 CDD:238060 5/43 (12%)
LDLa 1283..1318 CDD:238060 10/36 (28%)
LDLa 1340..1371 CDD:197566 6/30 (20%)
FXa_inhibition 1388..1416 CDD:291342 11/27 (41%)
EGF_CA 1418..1452 CDD:214542 2/33 (6%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1215
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100345
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
43.710

Return to query results.
Submit another query.