DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Hr78 and NR2C1

DIOPT Version :9

Sequence 1:NP_001189151.1 Gene:Hr78 / 40378 FlyBaseID:FBgn0015239 Length:601 Species:Drosophila melanogaster
Sequence 2:NP_003288.2 Gene:NR2C1 / 7181 HGNCID:7971 Length:603 Species:Homo sapiens


Alignment Length:576 Identity:167/576 - (28%)
Similarity:257/576 - (44%) Gaps:131/576 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly    50 ELCLVCGDRASGRHYGAISCEGCKGFFKRSIRKQLGYQCRGAMNCEVTKHHRNRCQFCRLQKCLA 114
            :||:||||:||||||||::||||||||||||||.|.|.|||:.:|.:.||||||||:||||:|:|
Human   111 DLCVVCGDKASGRHYGAVTCEGCKGFFKRSIRKNLVYSCRGSKDCIINKHHRNRCQYCRLQRCIA 175

  Fly   115 SGMRSDSVQHERKPI-VDRKEGIIAAAGSSSTSGGGNGSSTYLSGKSGYQQGRGKGHSVKAESAA 178
            .||:.||||.||||| |.|::....||.:         ...|:.            ..:::...|
Human   176 FGMKQDSVQCERKPIEVSREKSSNCAAST---------EKIYIR------------KDLRSPLTA 219

  Fly   179 TPPV----HSAPATAF---NLNENIFPMGLNFAELTQTLMFATQQQQQQQQQHQQSGSYSPDIPK 236
            ||..    .|..:|..   .:..||.|.|:.    |::.:..|..:.:..|..            
Human   220 TPTFVTDSESTRSTGLLDSGMFMNIHPSGVK----TESAVLMTSDKAESCQGD------------ 268

  Fly   237 ADPEDDEDDSMDNSSTLCLQLLANSASNNNSQHLNFNAGEVPTALPTT-STMGLIQSSLDMRVIH 300
                              |..|||                |.|:|... .|..|.|:|.:|.:| 
Human   269 ------------------LSTLAN----------------VVTSLANLGKTKDLSQNSNEMSMI- 298

  Fly   301 KGLQILQPIQN---------QLERNGNLSVKPECDSEAEDSGTEDAVDAELEHMELDFECGGNRS 356
                  :.:.|         :::.||::|...:..::|.:.|...|..:.:..||     |....
Human   299 ------ESLSNDDTSLCEFQEMQTNGDVSRAFDTLAKALNPGESTACQSSVAGME-----GSVHL 352

  Fly   357 GGSDFAINEAVFEQDLLTDVQCAFHVQPPTLVHSYLNIHYVCETGSRIIFLTIHTLRKVPVFEQL 421
            ...|.:||....|..||:|...||.:..|:.:..|||:||:.|:.||::||::|....:|.|:.|
Human   353 ITGDSSINYTEKEGPLLSDSHVAFRLTMPSPMPEYLNVHYIGESASRLLFLSMHWALSIPSFQAL 417

  Fly   422 EAHTQVKLLRGVWPALMAIALAQCQGQLSVPTIIGQFIQSTRQLADIDKIEPLKISKMANLTRTL 486
            .....:.|::..|..|..:.||||...::|.||:..|:.........||:...:...:......|
Human   418 GQENSISLVKAYWNELFTLGLAQCWQVMNVATILATFVNCLHNSLQQDKMSTERRKLLMEHIFKL 482

  Fly   487 HDFVQELQSLDVTDMEFGLLRLILLFNP-----------TLLQQRKERSLRGYVRRV---QLYAL 537
            .:|...:..|.:...|:..|:.|:||:|           ...|::.....:.|:.:.   ..|.|
Human   483 QEFCNSMVKLCIDGYEYAYLKAIVLFSPDHPSLENMEQIEKFQEKAYVEFQDYITKTYPDDTYRL 547

  Fly   538 SSLRRQGGIGGGEERFNVLVARLLPLSSLDAEAMEELFFANLVGQMQMDALIPFIL 593
            |.                |:.||..|..::|...|||||..|:|.:::|::||.||
Human   548 SR----------------LLLRLPALRLMNATITEELFFKGLIGNIRIDSVIPHIL 587

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Hr78NP_001189151.1 NR_DBD_TR2_like 47..133 CDD:143525 60/83 (72%)
NR_LBD_TR2_like 372..595 CDD:132750 64/236 (27%)
NR2C1NP_003288.2 Required for interaction with KAT2B. /evidence=ECO:0000250 1..178 48/66 (73%)
NR_DBD_TR2_like 108..194 CDD:143525 60/82 (73%)
NR_LBD_TR2_like 368..589 CDD:132750 64/236 (27%)
Required for interaction with NRIP1. /evidence=ECO:0000250 584..603 3/4 (75%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165144384
Domainoid 1 1.000 125 1.000 Domainoid score I5494
eggNOG 1 0.900 - - E33208_3B97G
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 258 1.000 Inparanoid score I3142
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG45830
OrthoDB 1 1.010 - - D145512at33208
OrthoFinder 1 1.000 - - FOG0002998
OrthoInspector 1 1.000 - - otm40297
orthoMCL 1 0.900 - - OOG6_106195
Panther 1 1.100 - - LDO PTHR24083
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X1991
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1312.770

Return to query results.
Submit another query.