Protein Alignment Hr78 and RXRG

DIOPT Version :9

• Sequence 1: NP_001189151.1
• Gene: Hr78 / 40378
• FlyBaseID: FBgn0015239
• Length: 601
• Species: Drosophila melanogaster
• Sequence 2: NP_008848.1
• Gene: RXRG / 6258
• HGNCID: 10479
• Length: 463
• Species: Homo sapiens
• Alignment Length: 578
• Identity: 127/578 - (21%)
• Similarity: 189/578 - (32%)
• Gaps: 246/578 - (42%)

  Fly    31 PLPG----GGVGMGAGASATLSVELCLVCGDRASGRHYGAISCEGCKGFFKRSIRKQLGYQCRGA 91
            ||||    |.:...:.:..:|...:|.:||||:||:|||..|||||||||||:|||.|.|.||..
Human   114 PLPGLPGIGNMNYPSTSPGSLVKHICAICGDRSSGKHYGVYSCEGCKGFFKRTIRKDLIYTCRDN 178

  Fly    92 MNCEVTKHHRNRCQFCRLQKCLASGMRSDSVQHERKPIVDRKEGIIAAAGSSSTSGGGNGSSTYL 156
            .:|.:.|..|||||:||.||||..||:.::||.||:...:|.|    :....:|||
Human   179 KDCLIDKRQRNRCQYCRYQKCLVMGMKREAVQEERQRSRERAE----SEAECATSG--------- 230

  Fly   157 SGKSGYQQGRGKGHSVKAESAATPPVHSAPATAFNLNENIFPMGLNFAELTQTLMFATQQQQQQQ 221
                                                                             
Human   231 ----------------------------------------------------------------- 230

  Fly   222 QQHQQSGSYSPDIPKADPEDDEDDSMDNSSTLCLQLLANSASNNNSQHLNFNAGEVPTALPTTST 286
              |:
Human   231 --HE------------------------------------------------------------- 232

  Fly   287 MGLIQSSLDMRVIHKGLQILQPIQNQLERNGNLSVKPECDSEAEDSGTEDAVDAELEHMELDFEC 351
                    ||           |::..||  ..|:|:|:         ||...|..:|:...|
Human   233 --------DM-----------PVERILE--AELAVEPK---------TESYGDMNMENSTND--- 264

  Fly   352 GGNRSGGSDFAINEAVFEQDLLTDVQCAFHVQPPTLVHSYLNIHYVCETGSRIIFLTIHTLRKVP 416
                                            |.|         .:|....:.:|..:...:::|
Human   265 --------------------------------PVT---------NICHAADKQLFTLVEWAKRIP 288

  Fly   417 VFEQLEAHTQVKLLRGVWPALMAIALA----QCQGQLSVPTIIGQFI-QSTRQLADIDKIEPLKI 476
            .|..|....||.|||..|..|:..:.:    ..|..:.:.|  |..: :|:...|.:..|
Human   289 HFSDLTLEDQVILLRAGWNELLIASFSHRSVSVQDGILLAT--GLHVHRSSAHSAGVGSI----- 346

  Fly   477 SKMANLTRTLHDFVQELQSLDVTDMEFGLLRLILLFNPT---LLQQRKERSLRGYV-RRVQLYAL 537
                 ..|.|.:.|.:::.:.:...|.|.||.|:||||.   |....:..:||..| ..::.|..
Human   347 -----FDRVLTELVSKMKDMQMDKSELGCLRAIVLFNPDAKGLSNPSEVETLREKVYATLEAYTK 406

  Fly   538 SSLRRQGGIGGGEERFNVLVARLLPLSSLDAEAMEELFFANLVGQMQMDALIPFILMT 595
            .....|.|      ||..|:.||..|.|:..:.:|.|||..|:|...:|..:..:|.|
Human   407 QKYPEQPG------RFAKLLLRLPALRSIGLKCLEHLFFFKLIGDTPIDTFLMEMLET 458

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hr78	NP_001189151.1	NR_DBD_TR2_like	47..133	CDD:143525	48/85 (56%)
		NR_LBD_TR2_like	372..595	CDD:132750	54/231 (23%)
RXRG	NP_008848.1	Modulating. /evidence=ECO:0000250	1..138		6/23 (26%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	18..53
		Nuc_recep-AF1	25..133	CDD:314658	5/18 (28%)
		NR_DBD_RXR	137..213	CDD:143514	45/75 (60%)
		Hinge	205..230		7/28 (25%)
		NR_LBD_RXR_like	233..441	CDD:132741	63/291 (22%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165144375
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.840