DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hr78 and RXRA

DIOPT Version :9

Sequence 1:	NP_001189151.1	Gene:	Hr78 / 40378	FlyBaseID:	FBgn0015239	Length:	601	Species:	Drosophila melanogaster
Sequence 2:	NP_002948.1	Gene:	RXRA / 6256	HGNCID:	10477	Length:	462	Species:	Homo sapiens

Alignment Length:	564	Identity:	128/564 - (22%)
Similarity:	189/564 - (33%)	Gaps:	251/564 - (44%)

- Green bases have known domain annotations that are detailed below.

  Fly    41 AGASATLSVELCLVCGDRASGRHYGAISCEGCKGFFKRSIRKQLGYQCRGAMNCEVTKHHRNRCQ 105
            :|..|:.:..:|.:||||:||:|||..|||||||||||::||.|.|.||...:|.:.|..|||||
Human   124 SGNMASFTKHICAICGDRSSGKHYGVYSCEGCKGFFKRTVRKDLTYTCRDNKDCLIDKRQRNRCQ 188

  Fly   106 FCRLQKCLASGMRSDSVQHERKPIVDRKEGIIAAAGSSSTSGGGNGSSTYLSGKSGYQQGRGKGH 170
            :||.|||||.||:.::||.||:                                      |||
Human   189 YCRYQKCLAMGMKREAVQEERQ--------------------------------------RGK-- 213

  Fly   171 SVKAESAATPPVHSAPATAFNLNENIFPMGLNFAELTQTLMFATQQQQQQQQQHQQSGSYSPDIP 235
                                :.|||
Human   214 --------------------DRNEN---------------------------------------- 218

  Fly   236 KADPEDDEDDSMDNSSTLCLQLLANSASNNNSQHLNFNAGEVPTALPTTSTMGLIQSSLDMRVIH 300
                                ::.:.|::|.                             ||
Human   219 --------------------EVESTSSANE-----------------------------DM---- 230

  Fly   301 KGLQILQPIQNQLERNGNLSVKPECDSEAEDSGTEDAVDAELEHMELDFECGGNRSGGSDFAINE 365
                   |::..||  ..|:|:|:         ||..|:|.:         |.|.|..:|...|
Human   231 -------PVERILE--AELAVEPK---------TETYVEANM---------GLNPSSPNDPVTN- 267

  Fly   366 AVFEQDLLTDVQCAFHVQPPTLVHSYLNIHYVCETGSRIIFLTIHTLRKVPVFEQLEAHTQVKLL 430
                                           :|:...:.:|..:...:::|.|.:|....||.||
Human   268 -------------------------------ICQAADKQLFTLVEWAKRIPHFSELPLDDQVILL 301

  Fly   431 RGVWPALMAIALAQCQGQLSVPTIIGQFIQSTRQLADIDKI---EPLKISKM--------ANLTR 484
            |..|..|                :|..|  |.|.:|..|.|   ..|.:.:.        |...|
Human   302 RAGWNEL----------------LIASF--SHRSIAVKDGILLATGLHVHRNSAHSAGVGAIFDR 348

  Fly   485 TLHDFVQELQSLDVTDMEFGLLRLILLFNPT---LLQQRKERSLRGYV-RRVQLYALSSLRRQGG 545
            .|.:.|.:::.:.:...|.|.||.|:||||.   |....:..:||..| ..::.|.......|.|
Human   349 VLTELVSKMRDMQMDKTELGCLRAIVLFNPDSKGLSNPAEVEALREKVYASLEAYCKHKYPEQPG 413

  Fly   546 IGGGEERFNVLVARLLPLSSLDAEAMEELFFANLVGQMQMDALI 589
                  ||..|:.||..|.|:..:.:|.|||..|:|...:|..:
Human   414 ------RFAKLLLRLPALRSIGLKCLEHLFFFKLIGDTPIDTFL 451

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hr78	NP_001189151.1	NR_DBD_TR2_like	47..133	CDD:143525	47/85 (55%)
Hr78	NP_001189151.1	NR_LBD_TR2_like	372..595	CDD:132750	54/233 (23%)
RXRA	NP_002948.1	Modulating. /evidence=ECO:0000250	1..134		2/9 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..107
		Nuc_recep-AF1	17..126	CDD:403126	0/1 (0%)
		NR_DBD_RXR	133..209	CDD:143514	45/75 (60%)
		Nuclear localization signal. /evidence=ECO:0000269\|PubMed:12145331	160..165		2/4 (50%)
		Hinge	201..224		10/142 (7%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	206..228		10/141 (7%)
		NR_LBD_RXR_like	229..440	CDD:132741	68/297 (23%)
		Required for nuclear export. /evidence=ECO:0000269\|PubMed:15509776	348..368		4/19 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165144387
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.840