DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hr78 and nr2c1

DIOPT Version :9

Sequence 1:	NP_001189151.1	Gene:	Hr78 / 40378	FlyBaseID:	FBgn0015239	Length:	601	Species:	Drosophila melanogaster
Sequence 2:	NP_001016207.1	Gene:	nr2c1 / 548961	XenbaseID:	XB-GENE-484727	Length:	636	Species:	Xenopus tropicalis

Alignment Length:	565	Identity:	179/565 - (31%)
Similarity:	265/565 - (46%)	Gaps:	113/565 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    49 VELCLVCGDRASGRHYGAISCEGCKGFFKRSIRKQLGYQCRGAMNCEVTKHHRNRCQFCRLQKCL 113
            ||||:||||:||||||||::||||||||||||||.|.|.|||:.:|.:.||:|||||:||||:|:
Frog   149 VELCVVCGDKASGRHYGAVTCEGCKGFFKRSIRKNLVYTCRGSKDCVINKHYRNRCQYCRLQRCI 213

  Fly   114 ASGMRSDSVQHERKPI-VDRKEGIIAAAGSSSTSGGGNGSSTYLSGKSGYQQGRGKGHSVKAESA 177
            |.||:.||||.||||| |.|::....||.:         ...|:.            ..:::..|
Frog   214 ALGMKQDSVQCERKPIEVSREKSSNCAAST---------EKIYIR------------KDLRSPLA 257

  Fly   178 ATPPVHSAPATAFNLNENIFPMGLNFAELTQTLMFATQQQQQQQQQHQQSGSYSPDIPKADPEDD 242
            ||        |.| :.||      ..:..|..|........||.....:|...:|        :.
Frog   258 AT--------TTF-VTEN------KTSRTTSLLDSGMLVNIQQSGVKNESILITP--------NK 299

  Fly   243 EDDSMDNSSTLCLQLLANSASNNNSQHLNFNAGEVPTALPTTSTMGLIQSSLDMRVIHKGLQILQ 307
            .|....:.|||. .::.:.|:.|.|:.           ||.|:|               .|.|::
Frog   300 VDACQGDLSTLA-NVVTSLANLNKSKE-----------LPQTNT---------------ELSIIE 337

  Fly   308 PIQNQLERNGNLSVKPECD-SEAEDSGTEDAVDAELEHMEL----DFECGGNRSGGSDFAINEAV 367
            .:.|   .:.:||...:.| |.:|.:...|.:...|...|.    ..||.|:.|..:|..:.
Frog   338 SLSN---GDSSLSELAQDDQSNSEVTRAFDTLAKALNQSENSAQGSSECVGSNSNLTDANVE--- 396

  Fly   368 FEQDLLTDVQCAFHVQPPTLVHSYLNIHYVCETGSRIIFLTIHTLRKVPVFEQLEAHTQVKLLRG 432
            .|..||:|...||.:..|:.:..|||:||:||:.||::||::|..|.:|.|:.|.....:.|::.
Frog   397 IEGPLLSDAHIAFRLTMPSPMPEYLNVHYICESASRLLFLSMHWARSIPSFQSLGQENSISLVKA 461

  Fly   433 VWPALMAIALAQCQGQLSVPTIIGQFIQSTRQLADIDKIEPLKISKMANLTRTLHDFVQELQSLD 497
            .|..|.::.||||...::|.||:..|:.........||:...|:..:.:....|.:|...:..|.
Frog   462 CWNELFSLGLAQCCQVMNVETILAAFVNHLHNSMQHDKLSADKVKLVMDHIFKLQEFCNSMVKLS 526

  Fly   498 VTDMEFGLLRLILLFNP-----------TLLQQRKERSLRGYVRRV---QLYALSSLRRQGGIGG 548
            |...|:..|:.|.||:|           ..||::.....:.||.:.   ..|.||.
Frog   527 VDGYEYAYLKAIALFSPDHPGLENVSHIEKLQEKAYMEFQDYVTKTYPEDTYRLSR--------- 582

  Fly   549 GEERFNVLVARLLPLSSLDAEAMEELFFANLVGQMQMDALIPFIL 593
                   |:.||..|..|:|...||||||.|:|.:|:|::||:||
Frog   583 -------LLLRLPALRLLNAAITEELFFAGLIGNVQIDSIIPYIL 620

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hr78	NP_001189151.1	NR_DBD_TR2_like	47..133	CDD:143525	61/84 (73%)
Hr78	NP_001189151.1	NR_LBD_TR2_like	372..595	CDD:132750	73/236 (31%)
nr2c1	NP_001016207.1	NR_DBD_TR2_like	147..233	CDD:143525	61/83 (73%)
nr2c1	NP_001016207.1	NR_LBD_TR2_like	401..622	CDD:132750	73/236 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	123	1.000	Domainoid score	I5511
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	274	1.000	Inparanoid score	I2904
OMA	1	1.010	-	-		QHG45830
OrthoDB	1	1.010	-	-		D145512at33208
OrthoFinder	1	1.000	-	-		FOG0002998
OrthoInspector	1	1.000	-	-		otm47474
Panther	1	1.100	-	-	LDO	PTHR24083
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1991
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	9.080