DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hr78 and dsf

DIOPT Version :9

Sequence 1:	NP_001189151.1	Gene:	Hr78 / 40378	FlyBaseID:	FBgn0015239	Length:	601	Species:	Drosophila melanogaster
Sequence 2:	NP_001260109.1	Gene:	dsf / 33823	FlyBaseID:	FBgn0015381	Length:	691	Species:	Drosophila melanogaster

Alignment Length:	738	Identity:	167/738 - (22%)
Similarity:	250/738 - (33%)	Gaps:	247/738 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    39 MGAGASATLSVELCLVCGDRASGRHYGAISCEGCKGFFKRSIRKQLGYQCRGAMN----CEVTKH 99
            ||......|.:. |.|||||:||:|||..||:||.|||||||.:...|.|:...:    |.|.|.
  Fly     1 MGTAGDRLLDIP-CKVCGDRSSGKHYGIYSCDGCSGFFKRSIHRNRIYTCKATGDLKGRCPVDKT 64

  Fly   100 HRNRCQFCRLQKCLASGMRSDSVQHERKPIVDRK------------------------------- 133
            |||:|:.|||.||..|.|..|:|||||.|   ||
  Fly    65 HRNQCRACRLAKCFQSAMNKDAVQHERGP---RKPKLHPQLHHHHHHAAAAAAAAHHAAAAHHHH 126

  Fly   134 ------------EGIIAAAGSS---------------------------ST-------------- 145
                        ...:|||.:|                           ||
  Fly   127 HHHHHAHAAAAHHAAVAAAAASGLHHHHHAMPVSLVTNVSASFNYTQHISTHPPAPAAPPSGFHL 191

  Fly   146 ------------------SGGGNGSSTYL--------------------SGKSGYQQGRGKG--- 169
                              .|.|:..:|..                    .|.|....|.|.|
  Fly   192 TASGAQQGPAPPAGHLHHGGAGHQHATAFHHPGHGHALPAPHGGVVSNPGGNSSAISGSGPGSTL 256

  Fly   170 --------HSVKAESAATPPVHSAPATAFNLNENIFPMGLNFAELTQTLMFATQQQQQQQQQHQQ 226
                    |::.||:|:..|..:|.|.|..::....|    :|...||...::............
  Fly   257 PFPSHLLHHNLIAEAASKLPGITATAVAAVVSSTSTP----YASAAQTSSPSSNNHNYSSPSPSN 317

  Fly   227 SGSYSPDIPKADPEDDEDDSMDNSSTLCLQLLANSASNNNSQHLNFNAGEVPTALPTTSTMGLIQ 291
            |......|.......:|..|:.:.|.. :.:...:.|.:||..|  :||.:..|...|::.|..|
  Fly   318 SIQSISSIGSRSGGGEEGLSLGSESPR-VNVETETPSPSNSPPL--SAGSISPAPTLTTSSGSPQ 379

  Fly   292 ---------SSLDMRVIHKGLQILQPIQNQLERNGNLSVKPECDSEAEDSGTEDAVDAELEHMEL 347
                     |.......|..|.|.....|....|.|            ::|         ||.:.
  Fly   380 HRQMSRHSLSEATTPPSHASLMICASNNNNNNNNNN------------NNG---------EHKQS 423

  Fly   348 DFECGG----------NRSG-GS--DFAINEAVFEQDLLTDVQC----AFHVQPPTLV------- 388
            .:..|.          .||| ||  :.|.:.:.|.:.||:..:|    .:.||..||:
  Fly   424 SYTSGSPTPTTPTPPPPRSGVGSTCNTASSSSGFLELLLSPDKCQELIQYQVQHNTLLFPQQLLD 488

  Fly   389 HSYLNIHYVCETGSRIIFLTIHTLRKVPVFEQLEAHTQVKLLRGVWPALMAIALAQCQGQLSVPT 453
            ...|:...:.||.:|::|:.:..::.:..|:.|..:.|..||:..|..|..:.|||....|.:..
  Fly   489 SRLLSWEMLQETTARLLFMAVRWVKCLMPFQTLSKNDQHLLLQESWKELFLLNLAQWTIPLDLTP 553

  Fly   454 IIGQFIQSTRQLADIDKIEPLKISKMANLTRTLHDFVQEL----QSLDVTDMEFGLLRLILLFNP 514
            |:...:...|.|.|             ..|:|....:||:    :.:.....|.|.::.|.||.|
  Fly   554 ILESPLIRERVLQD-------------EATQTEMKTIQEILCRFRQITPDGSEVGCMKAIALFAP 605

  Fly   515 -----------TLLQQRKERSLRGYVRRVQLYALSSLR--RQGGIGGGEERFNVLVARLLPLSSL 566
                       .:||.:.:..|..:||         ||  ||.      .||..|:..|..|.::
  Fly   606 ETAGLCDVQPVEMLQDQAQCILSDHVR---------LRYPRQA------TRFGRLLLLLPSLRTI 655

  Fly   567 DAEAMEELFFANLVGQMQMDALI 589
            .|..:|.|||...:|.:.:..|:
  Fly   656 RAATIEALFFKETIGNVPIARLL 678

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hr78	NP_001189151.1	NR_DBD_TR2_like	47..133	CDD:143525	46/89 (52%)
Hr78	NP_001189151.1	NR_LBD_TR2_like	372..595	CDD:132750	58/246 (24%)
dsf	NP_001260109.1	NR_DBD_TLX	5..98	CDD:143537	48/96 (50%)
dsf	NP_001260109.1	NR_LBD_Tlx_PNR_like	467..671	CDD:132748	54/231 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S7185
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24083
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.960