Protein Alignment Hr78 and HNF4A

DIOPT Version :9

• Sequence 1: NP_001189151.1
• Gene: Hr78 / 40378
• FlyBaseID: FBgn0015239
• Length: 601
• Species: Drosophila melanogaster
• Sequence 2: XP_005260464.1
• Gene: HNF4A / 3172
• HGNCID: 5024
• Length: 513
• Species: Homo sapiens
• Alignment Length: 590
• Identity: 125/590 - (21%)
• Similarity: 189/590 - (32%)
• Gaps: 248/590 - (42%)

  Fly    21 IGGG--SASGGTPLPGGGVGMGAGASATLSVELCLVCGDRASGRHYGAISCEGCKGFFKRSIRKQ 83
            |.||  |:..|...|..|..:.|..|..:|. ||.:|||||:|:||||.||:||||||:||:||.
Human    67 ISGGVDSSPQGDTSPSEGTNLNAPNSLGVSA-LCAICGDRATGKHYGASSCDGCKGFFRRSVRKN 130

  Fly    84 LGYQCRGAMNCEVTKHHRNRCQFCRLQKCLASGMRSDSVQHERKPIVDRKEGIIAAAGSSSTSGG 148
            ..|.||.:..|.|.|..||:|::|||:||..:||:.::||:||..|..|:
Human   131 HMYSCRFSRQCVVDKDKRNQCRYCRLKKCFRAGMKKEAVQNERDRISTRR--------------- 180

  Fly   149 GNGSSTYLSGKSGYQQGRGKGHSVKAESAATPPVHSAPATAFNLNENIFPMGLNFAELTQTLMFA 213
                |:|
Human   181 ----SSY---------------------------------------------------------- 183

  Fly   214 TQQQQQQQQQHQQSGSYSPDIPKADPEDDEDDSMDNSSTLCLQLLANSASNNNSQHLNFNAGEVP 278
                                         ||.|
Human   184 -----------------------------EDSS-------------------------------- 187

  Fly   279 TALPTTSTMGLIQSSLDMRVIHKGLQILQPIQNQLERNGNLSVKPECDSEAEDSGTEDAVDAELE 343
              ||:      |.:.|...|:.:  ||..|:..   .||::..|
Human   188 --LPS------INALLQAEVLSR--QITSPVSG---INGDIRAK--------------------- 218

  Fly   344 HMELDFECGGNRSGGSDFAINEAVFEQDLLTDVQCAFHVQPPTLVHSYLNIHYVCETGSRIIFLT 408
                                                          ...:|..|||:....:.:.
Human   219 ----------------------------------------------KIASIADVCESMKEQLLVL 237

  Fly   409 IHTLRKVPVFEQLEAHTQVKLLRGVWPALMAIALAQCQGQLSVPTIIGQFIQSTRQLADIDKIEP 473
            :...:.:|.|.:|....||.|||           |.....|.:.......:.....|...|.|.|
Human   238 VEWAKYIPAFCELPLDDQVALLR-----------AHAGEHLLLGATKRSMVFKDVLLLGNDYIVP 291

  Fly   474 LKISKMANLTRT----LHDFVQELQSLDVTDMEFGLLRLILLFNPTLLQQRKERSLRGYVRRVQL 534
            ....::|.::|.    |.:.|...|.|.:.|.|:..|:.|:.|:|    ..|..|..|.::|::.
Human   292 RHCPELAEMSRVSIRILDELVLPFQELQIDDNEYAYLKAIIFFDP----DAKGLSDPGKIKRLRS 352

  Fly   535 YALSSLR-----RQGGIGGGEERFNVLVARLLPLSSLDAEAMEELFFANLVGQMQMDALIPFILM 594
            ....||.     ||....|   ||..|:..|..|.|:..:.:|::.|..|.|..::|.|:..:|:
Human   353 QVQVSLEDYINDRQYDSRG---RFGELLLLLPTLQSITWQMIEQIQFIKLFGMAKIDNLLQEMLL 414

  Fly   595 TSNTS 599
            ..:.|
Human   415 GGSPS 419

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hr78	NP_001189151.1	NR_DBD_TR2_like	47..133	CDD:143525	46/85 (54%)
		NR_LBD_TR2_like	372..595	CDD:132750	52/231 (23%)
HNF4A	XP_005260464.1	NR_DBD_HNF4A	99..174	CDD:143518	42/74 (57%)
		NR_LBD_HNF4_like	190..412	CDD:132729	60/317 (19%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165144380
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.840