DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hr78 and Nr2c1

DIOPT Version :9

Sequence 1:	NP_001189151.1	Gene:	Hr78 / 40378	FlyBaseID:	FBgn0015239	Length:	601	Species:	Drosophila melanogaster
Sequence 2:	NP_665723.1	Gene:	Nr2c1 / 252924	RGDID:	3200	Length:	590	Species:	Rattus norvegicus

Alignment Length:	580	Identity:	165/580 - (28%)
Similarity:	256/580 - (44%)	Gaps:	140/580 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    50 ELCLVCGDRASGRHYGAISCEGCKGFFKRSIRKQLGYQCRGAMNCEVTKHHRNRCQFCRLQKCLA 114
            :||:||||:|||||||||:||||||||||||||.|.|.|||:.:|.:.||||||||:||||:|:|
  Rat    99 DLCVVCGDKASGRHYGAITCEGCKGFFKRSIRKNLVYSCRGSKDCIINKHHRNRCQYCRLQRCIA 163

  Fly   115 SGMRSDSVQHERKPI-VDRKEGIIAAAGSSSTSGGGNGSSTYLSGKSGYQQGRGKGHSVKAESAA 178
            .||:.||||.||||| |.|::....||.:         ...|:.            ..:::..||
  Rat   164 FGMKQDSVQCERKPIEVSREKSSNCAAST---------EKIYIR------------KDLRSPLAA 207

  Fly   179 TPPVHSAPATA-------FNLNENIFPMGLNFAELTQTLMFATQQQQQQQQQHQQSGSYSPDIPK 236
            ||...:...||       ..:..||.|.|:.    |:..:..|
  Rat   208 TPTFVTDSETARSTGLLDSGMFVNIHPSGIK----TEPALLMT---------------------- 246

  Fly   237 ADPEDDEDDSMDNSSTLCLQLLANSASNNNSQHLNFNAGEVPTALPTTSTMGLIQSSLDMRVIHK 301
                .|:.:|..........::.:.|:...::.|:...|::|          ::||      :..
  Rat   247 ----PDKAESCQGDLGTLASVVTSLANLGKAKDLSHCGGDLP----------VVQS------LRN 291

  Fly   302 GLQILQPIQNQLERNGNLS-------------VKPECDSEAED-SGTEDAVDAELEHMELDFECG 352
            |..........::.||::|             ..|.|.|..|. .|:...:..|...||
  Rat   292 GDTSFGAFHQDIQTNGDVSRAFDNLAKALTPGENPACQSPGESMEGSTHLIAGEPSCME------ 350

  Fly   353 GNRSGGSDFAINEAVFEQDLLTDVQCAFHVQPPTLVHSYLNIHYVCETGSRIIFLTIHTLRKVPV 417
              |.|             .||:|....|.:..|:.:..|||:||:.|:.||::||::|....:|.
  Rat   351 --REG-------------PLLSDSHVVFRLTMPSPMPEYLNVHYIGESASRLLFLSMHWALSIPS 400

  Fly   418 FEQLEAHTQVKLLRGVWPALMAIALAQCQGQLSVPTIIGQFIQSTRQLADIDKIEPLKISKMANL 482
            |:.|.....:.|::..|..|..:.||||...::|.||:..|:.........||:.|.:...:...
  Rat   401 FQALGQENSISLVKAYWNELFTLGLAQCWQVMNVATILATFVNCLHNSLQQDKMSPERRKLLMEH 465

  Fly   483 TRTLHDFVQELQSLDVTDMEFGLLRLILLFNP--------TLLQQRKERS---LRGYVRRV---Q 533
            ...|.:|...:..|.:...|:..|:.|:||:|        .|:::.:|::   .:.|:.|.   .
  Rat   466 IFKLQEFCNSMVKLCIDGHEYAYLKAIVLFSPDHPGLENMELIEKFQEKAYVEFQDYITRTYPDD 530

  Fly   534 LYALSSLRRQGGIGGGEERFNVLVARLLPLSSLDAEAMEELFFANLVGQMQMDALIPFIL 593
            .|.||.                |:.||..|..::|...|||||..|:|.:::|::||.||
  Rat   531 TYRLSR----------------LLLRLPALRLMNATITEELFFKGLIGNVRIDSVIPHIL 574

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hr78	NP_001189151.1	NR_DBD_TR2_like	47..133	CDD:143525	61/83 (73%)
Hr78	NP_001189151.1	NR_LBD_TR2_like	372..595	CDD:132750	66/236 (28%)
Nr2c1	NP_665723.1	Required for interaction with KAT2B. /evidence=ECO:0000250	1..166		49/66 (74%)
		NR_DBD_TR2_like	96..182	CDD:143525	61/82 (74%)
		NR_LBD_TR2_like	355..576	CDD:132750	66/236 (28%)
		Required for interaction with NRIP1. /evidence=ECO:0000250	571..590		3/4 (75%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166338101
Domainoid	1	1.000	125	1.000	Domainoid score	I5341
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	259	1.000	Inparanoid score	I3049
OMA	1	1.010	-	-		QHG45830
OrthoDB	1	1.010	-	-		D145512at33208
OrthoFinder	1	1.000	-	-		FOG0002998
OrthoInspector	1	1.000	-	-		otm44425
orthoMCL	1	0.900	-	-		OOG6_106195
Panther	1	1.100	-	-	LDO	PTHR24083
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1991
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	12	11.910