Protein Alignment Hr78 and Nr2f6

DIOPT Version :10

• Sequence 1: NP_730636.1
• Gene: Hr78 / 40378
• FlyBaseID: FBgn0015239
• Length: 601
• Species: Drosophila melanogaster
• Sequence 2: NP_620813.2
• Gene: Nr2f6 / 245980
• RGDID: 621685
• Length: 390
• Species: Rattus norvegicus
• Alignment Length: 625
• Identity: 137/625 - (21%)
• Similarity: 199/625 - (31%)
• Gaps: 287/625 - (45%)

  Fly    18 MPLIGGGSASGGTPLPGG---GVGMGAGA-------------SATLSVEL-----------CLVC 55
            |.::.||  .||   |||   ||....|:             .||...|.           |:||
  Rat     1 MAMVTGG--WGG---PGGDTNGVDKAGGSYPRATEDDSASPPGATSDAEPGDEERPGLQVDCVVC 60

  Fly    56 GDRASGRHYGAISCEGCKGFFKRSIRKQLGYQCRGAMNCEVTKHHRNRCQFCRLQKCLASGMRSD 120
            ||::||:|||..:|||||.|||||||:.|.|.||...:|::.:||||:||:|||:||...|||.:
  Rat    61 GDKSSGKHYGVFTCEGCKSFFKRSIRRNLSYTCRSNRDCQIDQHHRNQCQYCRLKKCFRVGMRKE 125

  Fly   121 SVQHERKPIVDRKEGIIAAAGSSSTSGGGNGSSTYLSGKSGYQQGRGKGHSVKAESAATPPVHSA 185
            :||..|.|                                         |::...:|.:||
  Rat   126 AVQRGRIP-----------------------------------------HALPGPAACSPP---- 145

  Fly   186 PATAFNLNENIFPMGLNFAELTQTLMFATQQQQQQQQQHQQSGSYSPDIPKADPEDDEDDSMDNS 250
                                                      |:
  Rat   146 ------------------------------------------GA--------------------- 147

  Fly   251 STLCLQLLANSASNNNSQHLNFNAGEVPTALPTTSTMGLIQSSLDMRVIHKGLQILQPIQNQLER 315
                                   ||..|.|.|..|.:
  Rat   148 -----------------------AGVEPFAGPPVSEL---------------------------- 161

  Fly   316 NGNLSVKPECDSEAEDSGTEDAVDAELEHMELDFECGGNRSGGSDFAINEAVFEQDLLTDVQCAF 380
                                   .|:|...| .:...|...||.
  Rat   162 -----------------------IAQLLRAE-PYPAAGRFGGGG--------------------- 181

  Fly   381 HVQPPTLVHSYLNIHYVCETGSRIIFLTIHTLRKVPVFEQLEAHTQVKLLRGVWPALMAIALAQC 445
                     :.|.|..|||..:|::|.|:...|..|.|.:|.|..||.|||..|..|..:..||.
  Rat   182 ---------AVLGIDNVCELAARLLFSTVEWARHAPFFPELPAADQVALLRLSWSELFVLNAAQA 237

  Fly   446 QGQLSVPTIIGQF------IQSTRQLADIDKIEPLKISKMANLTRTLHDFVQELQSLDVTDMEFG 504
            ...|....::...      :.:.|.:|.:|::            |...:.|.:|..|.|...|:|
  Rat   238 ALPLHTAPLLAAAGLHAAPMAAERAVAFMDQV------------RAFQEQVDKLGRLQVDAAEYG 290

  Fly   505 LLRLILLFNPTL-----------LQQRKERSLRGYVRRVQLYALSSLRRQGGIGGGEERFNVLVA 558
            .|:.|.||.|..           ||::.:.:|..|||             .......:||..|:.
  Rat   291 CLKAIALFTPDACGLSDPAHVESLQEKAQVALTEYVR-------------AQYPSQPQRFGRLLL 342

  Fly   559 RLLPLSSLDAEAMEELFFANLVGQMQMDALIPFILMTSNT 598
            ||..|.::.|..:.:|||..|||:..::.||..:|::.:|
  Rat   343 RLPALRAVPASLISQLFFMRLVGKTPIETLIRDMLLSGST 382

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hr78	NP_730636.1	NR_DBD_TR2_like	47..133	CDD:143525	46/96 (48%)
		NR_LBD_TR2_like	372..595	CDD:132750	60/239 (25%)
Nr2f6	NP_620813.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..50		14/53 (26%)
		NR_DBD_COUP_TF	57..129	CDD:143516	42/71 (59%)
		NR_LBD_COUP-TF	157..387	CDD:132746	68/333 (20%)
		Important for dimerization. /evidence=ECO:0000250	314..390		23/82 (28%)