Protein Alignment Hr78 and NR2F6

DIOPT Version :9

• Sequence 1: NP_001189151.1
• Gene: Hr78 / 40378
• FlyBaseID: FBgn0015239
• Length: 601
• Species: Drosophila melanogaster
• Sequence 2: NP_005225.2
• Gene: NR2F6 / 2063
• HGNCID: 7977
• Length: 404
• Species: Homo sapiens
• Alignment Length: 608
• Identity: 138/608 - (22%)
• Similarity: 206/608 - (33%)
• Gaps: 261/608 - (42%)

  Fly    12 SEENRAMPLIGGGSASGGTP----LPGGGVGMGAGASATLSVELCLVCGDRASGRHYGAISCEGC 72
            :|::.|.|   .|:||...|    .||            |.|: |:||||::||:|||..:||||
Human    28 AEDDSASP---PGAASDAEPGDEERPG------------LQVD-CVVCGDKSSGKHYGVFTCEGC 76

  Fly    73 KGFFKRSIRKQLGYQCRGAMNCEVTKHHRNRCQFCRLQKCLASGMRSDSVQHERKPIVDRKEGII 137
            |.|||||||:.|.|.||...:|::.:||||:||:|||:||...|||.::||..|.|     ..:.
Human    77 KSFFKRSIRRNLSYTCRSNRDCQIDQHHRNQCQYCRLKKCFRVGMRKEAVQRGRIP-----HSLP 136

  Fly   138 AAAGSSSTSGGGNGSSTYLSGKSGYQQGRGKGHSVKAESAATPPVHSAPATAFNLNENIFPMGLN 202
            .|..:||.|..|:..:...||                                   .::|| |..
Human   137 GAVAASSGSPPGSALAAVASG-----------------------------------GDLFP-GQP 165

  Fly   203 FAELTQTLMFATQQQQQQQQQHQQSGSYSPDIPKADPEDDEDDSMDNSSTLCLQLLANSASNNNS 267
            .:||...|:                        :|:|
Human   166 VSELIAQLL------------------------RAEP---------------------------- 178

  Fly   268 QHLNFNAGEVPTALPTTSTMGLIQSSLDMRVIHKGLQILQPIQNQLERNGNLSVKPECDSEAEDS 332
                     .|.|                                                   :
Human   179 ---------YPAA---------------------------------------------------A 183

  Fly   333 GTEDAVDAELEHMELDFECGGNRSGGSDFAINEAVFEQDLLTDVQCAFHVQPPTLVHSYLNIHYV 397
            |.              |..||..:|                                :.|.|..|
Human   184 GR--------------FGAGGGAAG--------------------------------AVLGIDNV 202

  Fly   398 CETGSRIIFLTIHTLRKVPVFEQLEAHTQVKLLRGVWPALMAIALAQCQGQLSVPTIIGQF---- 458
            ||..:|::|.|:...|..|.|.:|....||.|||..|..|..:..||....|....::...
Human   203 CELAARLLFSTVEWARHAPFFPELPVADQVALLRLSWSELFVLNAAQAALPLHTAPLLAAAGLHA 267

  Fly   459 --IQSTRQLADIDKIEPLKISKMANLTRTLHDFVQELQSLDVTDMEFGLLRLILLFNPTL----- 516
              :.:.|.:|.:|::            |...:.|.:|..|.|...|:|.|:.|.||.|..
Human   268 APMAAERAVAFMDQV------------RAFQEQVDKLGRLQVDSAEYGCLKAIALFTPDACGLSD 320

  Fly   517 ------LQQRKERSLRGYVRRVQLYALSSLRRQGGIGGGEERFNVLVARLLPLSSLDAEAMEELF 575
                  ||::.:.:|..|||             .......:||..|:.||..|.::.|..:.:||
Human   321 PAHVESLQEKAQVALTEYVR-------------AQYPSQPQRFGRLLLRLPALRAVPASLISQLF 372

  Fly   576 FANLVGQMQMDALIPFILMTSNT 598
            |..|||:..::.||..:|::.:|
Human   373 FMRLVGKTPIETLIRDMLLSGST 395

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hr78	NP_001189151.1	NR_DBD_TR2_like	47..133	CDD:143525	47/85 (55%)
		NR_LBD_TR2_like	372..595	CDD:132750	59/239 (25%)
NR2F6	NP_005225.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..49		7/23 (30%)
		NR_DBD_COUP_TF	56..128	CDD:143516	42/71 (59%)
		NR_LBD_COUP-TF	165..400	CDD:132746	72/414 (17%)
		Important for dimerization. /evidence=ECO:0000250	327..404		23/82 (28%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165144378
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.840