Protein Alignment Hr78 and nhr-41

DIOPT Version :9

• Sequence 1: NP_001189151.1
• Gene: Hr78 / 40378
• FlyBaseID: FBgn0015239
• Length: 601
• Species: Drosophila melanogaster
• Sequence 2: NP_500073.3
• Gene: nhr-41 / 190865
• WormBaseID: WBGene00022423
• Length: 615
• Species: Caenorhabditis elegans
• Alignment Length: 584
• Identity: 144/584 - (24%)
• Similarity: 225/584 - (38%)
• Gaps: 193/584 - (33%)

  Fly    50 ELCLVCGDRASGRHYGAISCEGCKGFFKRSIRKQLGYQCRGAMNCEVTKHHRNRCQFCRLQKCLA 114
            |||:||||:||||||||:|||||||||||||||::||.||...:|.|||.||||||:|||:|||:
 Worm   150 ELCVVCGDKASGRHYGAVSCEGCKGFFKRSIRKRIGYVCRSQKDCPVTKFHRNRCQYCRLRKCLS 214

  Fly   115 SGMRSDSVQHERKPIVDRKEGIIAAAGSSSTSGGGNGSSTYLSGKSGYQQGRGKGHSVKAESAAT 179
            .||||:|||.||:|:                     .:|:.|......||.             |
 Worm   215 MGMRSESVQAERRPV---------------------NNSSMLCNNDNNQQN-------------T 245

  Fly   180 PPVHSAPATAFNLNENIFPMGLNFAELTQTLMFATQQQQQQQQQHQQSGSYSPDIP-----KADP 239
            .|.|.:|                      .|:.:..:.:.:.:.........|..|     ..|.
 Worm   246 TPEHLSP----------------------NLLLSLVKLEHETKLGGLEALIKPGSPVMLQNTQDY 288

  Fly   240 EDDEDDSMDNSSTLCLQLLANSASNNNSQHLNFNAGEVPTALPTTSTMGLIQSSLDMRVIHKGLQ 304
            .|.:.:|:.......:.|:.                  |:|.||:|.:|
 Worm   289 MDVKRESIGEDEMTVIGLVP------------------PSASPTSSGVG---------------- 319

  Fly   305 ILQPIQNQLERNGNLSVKPECDSEAEDSGTEDAVDAELEHMELDFECGGNRSGGSDFAINEAVFE 369
                               ...|.::|||
 Worm   320 -------------------SSSSISDDSG------------------------------------ 329

  Fly   370 QDLLTDVQCAFHVQPPTLVHSYLNIHYVCETGSRIIFLTIHTLRKVPVFEQLEAHTQVKLLRGVW 434
             .:.|..:..|.:..|....:..|..|:.|..:|::|||:|.::...|  .|...|...||:..|
 Worm   330 -PIYTSERARFEISVPLNTQNPRNHQYISEITTRLLFLTVHFVKDSRV--SLRTSTMEGLLKSKW 391

  Fly   435 PALMAIALAQCQGQLSVPTIIGQFIQS-TRQLA---DIDKIEPLKISKMANLTRTLHDFVQELQS 495
            ..|..:||.|...::.    :||.:.: |.|:|   :..:....|..|::...:.|....|...|
 Worm   392 CDLYILALMQTADKIK----LGQLLDNLTNQMAMGMECGQYSAEKFEKISEQMQRLLQLSQLFAS 452

  Fly   496 LDVTDMEFGLLRLILLFN---PTLLQQRKERSLRGYVRRVQLYALSSLR---------------- 541
            .::|.:|:..|::|....   |:.:...:.||:.....:.....:||.:
 Worm   453 RELTAVEYAYLKMISFTAQDLPSSMASPETRSVNQMASQELFEYVSSSKSTQNHMSNEHINVDDS 517

  Fly   542 -----------RQGGIGGGEERFNVLVARLLP-LSSLDAEAMEELFFANLVGQMQMDALIPFIL 593
                       :|..:....|||: .:.:||| |...|...:.|:||:.|:|.|.::.:|||:|
 Worm   518 TSEDNDTHVTSQQSSVNIAAERFS-RILQLLPCLRWFDPATIVEIFFSGLIGPMSIETIIPFVL 580

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hr78	NP_001189151.1	NR_DBD_TR2_like	47..133	CDD:143525	60/82 (73%)
		NR_LBD_TR2_like	372..595	CDD:132750	59/257 (23%)
nhr-41	NP_500073.3	Amelogenin	<6..105	CDD:197891
		NR_DBD_TR2_like	147..233	CDD:143525	60/103 (58%)
		NR_LBD	339..582	CDD:386099	58/249 (23%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160167667
Domainoid	1	1.000	126	1.000	Domainoid score	I3357
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	204	1.000	Inparanoid score	I2441
Isobase	1	0.950	-	0	Normalized mean entropy	S7185
OMA	1	1.010	-	-		QHG45830
OrthoDB	1	1.010	-	-		D145512at33208
OrthoFinder	1	1.000	-	-		FOG0002998
OrthoInspector	1	1.000	-	-		otm14568
orthoMCL	1	0.900	-	-		OOG6_106195
Panther	1	1.100	-	-	LDO	PTHR24083
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1991
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	15	14.820