DRSC/TRiP Functional Genomics Resources

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Protein Alignment Hr78 and nhr-41

DIOPT Version :10

Sequence 1:NP_730636.1 Gene:Hr78 / 40378 FlyBaseID:FBgn0015239 Length:601 Species:Drosophila melanogaster
Sequence 2:NP_500073.3 Gene:nhr-41 / 190865 WormBaseID:WBGene00022423 Length:615 Species:Caenorhabditis elegans


Alignment Length:584 Identity:144/584 - (24%)
Similarity:225/584 - (38%) Gaps:193/584 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly    50 ELCLVCGDRASGRHYGAISCEGCKGFFKRSIRKQLGYQCRGAMNCEVTKHHRNRCQFCRLQKCLA 114
            |||:||||:||||||||:|||||||||||||||::||.||...:|.|||.||||||:|||:|||:
 Worm   150 ELCVVCGDKASGRHYGAVSCEGCKGFFKRSIRKRIGYVCRSQKDCPVTKFHRNRCQYCRLRKCLS 214

  Fly   115 SGMRSDSVQHERKPIVDRKEGIIAAAGSSSTSGGGNGSSTYLSGKSGYQQGRGKGHSVKAESAAT 179
            .||||:|||.||:|:                     .:|:.|......||.             |
 Worm   215 MGMRSESVQAERRPV---------------------NNSSMLCNNDNNQQN-------------T 245

  Fly   180 PPVHSAPATAFNLNENIFPMGLNFAELTQTLMFATQQQQQQQQQHQQSGSYSPDIP-----KADP 239
            .|.|.:|                      .|:.:..:.:.:.:.........|..|     ..|.
 Worm   246 TPEHLSP----------------------NLLLSLVKLEHETKLGGLEALIKPGSPVMLQNTQDY 288

  Fly   240 EDDEDDSMDNSSTLCLQLLANSASNNNSQHLNFNAGEVPTALPTTSTMGLIQSSLDMRVIHKGLQ 304
            .|.:.:|:.......:.|:.                  |:|.||:|.:|                
 Worm   289 MDVKRESIGEDEMTVIGLVP------------------PSASPTSSGVG---------------- 319

  Fly   305 ILQPIQNQLERNGNLSVKPECDSEAEDSGTEDAVDAELEHMELDFECGGNRSGGSDFAINEAVFE 369
                               ...|.::|||                                    
 Worm   320 -------------------SSSSISDDSG------------------------------------ 329

  Fly   370 QDLLTDVQCAFHVQPPTLVHSYLNIHYVCETGSRIIFLTIHTLRKVPVFEQLEAHTQVKLLRGVW 434
             .:.|..:..|.:..|....:..|..|:.|..:|::|||:|.::...|  .|...|...||:..|
 Worm   330 -PIYTSERARFEISVPLNTQNPRNHQYISEITTRLLFLTVHFVKDSRV--SLRTSTMEGLLKSKW 391

  Fly   435 PALMAIALAQCQGQLSVPTIIGQFIQS-TRQLA---DIDKIEPLKISKMANLTRTLHDFVQELQS 495
            ..|..:||.|...::.    :||.:.: |.|:|   :..:....|..|::...:.|....|...|
 Worm   392 CDLYILALMQTADKIK----LGQLLDNLTNQMAMGMECGQYSAEKFEKISEQMQRLLQLSQLFAS 452

  Fly   496 LDVTDMEFGLLRLILLFN---PTLLQQRKERSLRGYVRRVQLYALSSLR---------------- 541
            .::|.:|:..|::|....   |:.:...:.||:.....:.....:||.:                
 Worm   453 RELTAVEYAYLKMISFTAQDLPSSMASPETRSVNQMASQELFEYVSSSKSTQNHMSNEHINVDDS 517

  Fly   542 -----------RQGGIGGGEERFNVLVARLLP-LSSLDAEAMEELFFANLVGQMQMDALIPFIL 593
                       :|..:....|||: .:.:||| |...|...:.|:||:.|:|.|.::.:|||:|
 Worm   518 TSEDNDTHVTSQQSSVNIAAERFS-RILQLLPCLRWFDPATIVEIFFSGLIGPMSIETIIPFVL 580

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Hr78NP_730636.1 NR_DBD_TR2_like 47..133 CDD:143525 60/82 (73%)
NR_LBD_TR2_like 372..595 CDD:132750 59/257 (23%)
nhr-41NP_500073.3 Amelogenin <6..105 CDD:197891
NR_DBD_TR2_like 147..233 CDD:143525 60/103 (58%)
NR_LBD 339..582 CDD:472173 58/249 (23%)
Blue background indicates that the domain is not in the aligned region.

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