Protein Alignment Hr78 and nhr-47

DIOPT Version :9

• Sequence 1: NP_001189151.1
• Gene: Hr78 / 40378
• FlyBaseID: FBgn0015239
• Length: 601
• Species: Drosophila melanogaster
• Sequence 2: NP_504455.1
• Gene: nhr-47 / 178933
• WormBaseID: WBGene00003637
• Length: 579
• Species: Caenorhabditis elegans
• Alignment Length: 621
• Identity: 126/621 - (20%)
• Similarity: 219/621 - (35%)
• Gaps: 166/621 - (26%)

  Fly    51 LCLVCGDRASGRHYGAISCEGCKGFFKRSIRKQLGYQCRGAMNCEVTKHHRNRCQFCRLQKCLAS 115
            ||.||.|.|:|:||...||.|||.||:|::.....:.|:|..:|.|.|..|..|::||||||||.
 Worm    10 LCAVCDDIATGKHYSVASCNGCKTFFRRALVNNREFVCQGNKDCPVNKGVRCACRYCRLQKCLAV 74

  Fly   116 GMRSDSVQHERKPI--VDRKEGIIAAAGSSSTSGGGNGSSTYLSGKSGYQQGRGKG------HSV 172
            ||..:|:|::|..|  ..||.    ....:...||.:.|.....|.||..|...:.      ..:
 Worm    75 GMDKNSIQNDRDRIGYTKRKR----RHDDNDMEGGVHHSEHIRDGSSGSPQMNDESPESMDMKDI 135

  Fly   173 KAESAATPPVHSAPATAFNLNENIFPMGL-------NFAELTQTLMFATQQQQQQQQQHQQSGSY 230
            |.:.....|:    |......||.|.:.|       ::|.|...|...::..|      ..|..:
 Worm   136 KIDLNCLDPI----ADRLTTLENNFTLLLSRCADLHSYATLEDALNAPSRFMQ------PISCEW 190

  Fly   231 SPDIPKADPEDDEDDSM------------DNSSTLC----------LQLLANSASN--------N 265
            |.::...    :.||.:            |.:.|..          :.::.|.||:        .
 Worm   191 SDNVVLT----NRDDKLPFWRQRLIALYIDWAKTFSTFRSLPYADKVAMVTNHASSFMIMCEAFR 251

  Fly   266 NSQHLNFNAGEVPTALP--TTSTMGLIQSSLDMRVIHKGLQILQPIQNQLERNGNLSVKPECDSE 328
            ..:|:..:.......||  .||..|            .|...:..:...|..||
 Worm   252 TPEHMKSDVVRKRPDLPNIVTSNSG------------SGCSRVSSVAGSLVSNG----------- 293

  Fly   329 AEDSGTEDAVDAELEHMELDFECGGNRSGGSDFAINEAVFEQDLLTDVQCAFHVQPPTLVHSYLN 393
                  ||..| :|.:: |...|       ...:||:.:...:..:|.:.
 Worm   294 ------EDVHD-DLTNL-LHAAC-------IQQSINKGIMFGENSSDDKI--------------- 328

  Fly   394 IHYVCETGSRIIFLTIHTLRKVPV-FEQLEAHTQVKLLRGVWPALMAIALAQCQGQLSVPTI--- 454
                      ::.|.|..::|.|: ....|...|:....|..||..|..:.|..|.   ||.
 Worm   329 ----------LLNLPIREIKKEPLEVPSTEGMIQLPTEYGNLPADYASWIPQDYGH---PTAGHE 380

  Fly   455 ----IGQFIQ--------------STRQLADIDKIEPLKI-SKMAN----------LTRTLHDFV 490
                :..|.:              :.|.:..:..:|.... |..||          ||..:...:
 Worm   381 GKSDMHNFFEARDFCVGRPSSCNLNERSMKTVSMLESRNFQSPSANNSSLSGITPVLTMMIDLVM 445

  Fly   491 QELQSLDVTDMEFGLLRLILLFNPTL--LQQRKERSLRGYVRRVQLYALSSLRRQGGIGGGEERF 553
            :..:.|:.:..||.||:.|:.|:|..  |....:|::....:::.......|::........||:
 Worm   446 KPFRQLNFSTTEFALLQAIMFFDPDTEGLDSASQRNVVAEQKKLLAVLFRHLQKAYNPQAASERY 510

  Fly   554 NVLVARLLPLSSLDAEAMEELFFANLVGQMQMDALI 589
            ..::.|:..:....|:..|.|...:::...::::|:
 Worm   511 ASIILRMPSIRRAAAKKNESLQVLDMLQMHEINSLV 546

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hr78	NP_001189151.1	NR_DBD_TR2_like	47..133	CDD:143525	38/83 (46%)
		NR_LBD_TR2_like	372..595	CDD:132750	41/253 (16%)
nhr-47	NP_504455.1	NR_DBD_HNF4A	11..86	CDD:143518	35/74 (47%)
		HOLI	<423..523	CDD:214658	18/99 (18%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	1	0.960