Protein Alignment Hr78 and Hnf4a

DIOPT Version :9

• Sequence 1: NP_001189151.1
• Gene: Hr78 / 40378
• FlyBaseID: FBgn0015239
• Length: 601
• Species: Drosophila melanogaster
• Sequence 2: NP_032287.2
• Gene: Hnf4a / 15378
• MGIID: 109128
• Length: 474
• Species: Mus musculus
• Alignment Length: 581
• Identity: 122/581 - (20%)
• Similarity: 184/581 - (31%)
• Gaps: 246/581 - (42%)

  Fly    28 GGTPLPGGGVGMGAGASATLSVELCLVCGDRASGRHYGAISCEGCKGFFKRSIRKQLGYQCRGAM 92
            |....|..|..:.:..|..:|. ||.:|||||:|:||||.||:||||||:||:||...|.||.:.
Mouse    37 GNDTSPSEGANLNSSNSLGVSA-LCAICGDRATGKHYGASSCDGCKGFFRRSVRKNHMYSCRFSR 100

  Fly    93 NCEVTKHHRNRCQFCRLQKCLASGMRSDSVQHERKPIVDRKEGIIAAAGSSSTSGGGNGSSTYLS 157
            .|.|.|..||:|::|||:||..:||:.::||:||..|..|:                   |:|
Mouse   101 QCVVDKDKRNQCRYCRLKKCFRAGMKKEAVQNERDRISTRR-------------------SSY-- 144

  Fly   158 GKSGYQQGRGKGHSVKAESAATPPVHSAPATAFNLNENIFPMGLNFAELTQTLMFATQQQQQQQQ 222
                                                                             
Mouse   145 ----------------------------------------------------------------- 144

  Fly   223 QHQQSGSYSPDIPKADPEDDEDDSMDNSSTLCLQLLANSASNNNSQHLNFNAGEVPTALPTTSTM 287
                                ||.|                                  ||:
Mouse   145 --------------------EDSS----------------------------------LPS---- 151

  Fly   288 GLIQSSLDMRVIHKGLQILQPIQNQLERNGNLSVKPECDSEAEDSGTEDAVDAELEHMELDFECG 352
              |.:.|...|:.:  ||..||..   .||::..|
Mouse   152 --INALLQAEVLSQ--QITSPISG---INGDIRAK------------------------------ 179

  Fly   353 GNRSGGSDFAINEAVFEQDLLTDVQCAFHVQPPTLVHSYLNIHYVCETGSRIIFLTIHTLRKVPV 417
                                                 ...||..|||:....:.:.:...:.:|.
Mouse   180 -------------------------------------KIANITDVCESMKEQLLVLVEWAKYIPA 207

  Fly   418 FEQLEAHTQVKLLRGVWPALMAIALAQCQGQLSVPTIIGQFIQSTRQLADIDKIEPLKISKMANL 482
            |.:|....||.|||           |.....|.:.......:.....|...|.|.|....::|.:
Mouse   208 FCELLLDDQVALLR-----------AHAGEHLLLGATKRSMVFKDVLLLGNDYIVPRHCPELAEM 261

  Fly   483 TRT----LHDFVQELQSLDVTDMEFGLLRLILLFNPTLLQQRKERSLRGYVRRVQLYALSSLR-- 541
            :|.    |.:.|...|.|.:.|.|:..|:.|:.|:|    ..|..|..|.::|::.....||.
Mouse   262 SRVSIRILDELVLPFQELQIDDNEYACLKAIIFFDP----DAKGLSDPGKIKRLRSQVQVSLEDY 322

  Fly   542 ---RQGGIGGGEERFNVLVARLLPLSSLDAEAMEELFFANLVGQMQMDALIPFILMTSNTS 599
               ||....|   ||..|:..|..|.|:..:.:|::.|..|.|..::|.|:..:|:..:.|
Mouse   323 INDRQYDSRG---RFGELLLLLPTLQSITWQMIEQIQFIKLFGMAKIDNLLQEMLLGGSAS 380

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hr78	NP_001189151.1	NR_DBD_TR2_like	47..133	CDD:143525	46/85 (54%)
		NR_LBD_TR2_like	372..595	CDD:132750	53/231 (23%)
Hnf4a	NP_032287.2	NR_DBD_HNF4A	60..135	CDD:143518	42/74 (57%)
		NR_LBD_HNF4_like	151..373	CDD:132729	62/317 (20%)
		9aaTAD. /evidence=ECO:0000250|UniProtKB:P41235	368..376		2/7 (29%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	413..450

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167834519
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.840