Protein Alignment Hr78 and Nr2f2

DIOPT Version :9

• Sequence 1: NP_001189151.1
• Gene: Hr78 / 40378
• FlyBaseID: FBgn0015239
• Length: 601
• Species: Drosophila melanogaster
• Sequence 2: NP_033827.2
• Gene: Nr2f2 / 11819
• MGIID: 1352452
• Length: 414
• Species: Mus musculus
• Alignment Length: 617
• Identity: 133/617 - (21%)
• Similarity: 204/617 - (33%)
• Gaps: 262/617 - (42%)

  Fly    12 SEENRAMPLIG--------------GGSASGGTPLPGGGVGMGAGASATLSVEL----CLVCGDR 58
            |:.::|.|:.|              ||.||.......||.|...|..:....:.    |:||||:
Mouse    21 SQASQAPPVPGPPPGAPHTPQTPGQGGPASTPAQTAAGGQGGPGGPGSDKQQQQQHIECVVCGDK 85

  Fly    59 ASGRHYGAISCEGCKGFFKRSIRKQLGYQCRGAMNCEVTKHHRNRCQFCRLQKCLASGMRSDSVQ 123
            :||:|||..:|||||.|||||:|:.|.|.||...||.:.:||||:||:|||:|||..|||.::||
Mouse    86 SSGKHYGQFTCEGCKSFFKRSVRRNLSYTCRANRNCPIDQHHRNQCQYCRLKKCLKVGMRREAVQ 150

  Fly   124 HERKPIVDRKEGIIAAAGSSSTSGGGNGSSTYLSGKSGYQQGRGKGHSVKAESAATPPVHSAPAT 188
            ..|.|......|..|.     |:|......:||||
Mouse   151 RGRMPPTQPTHGQFAL-----TNGDPLNCHSYLSG------------------------------ 180

  Fly   189 AFNLNENIFPMGLNFAELTQTLMFATQQQQQQQQQHQQSGSYSPDIPKADPEDDEDDSMDNSSTL 253
                                                     |...:.:|:|
Mouse   181 -----------------------------------------YISLLLRAEP-------------- 190

  Fly   254 CLQLLANSASNNNSQHLNFNAGEVPTALPTTSTMGLIQSSLDMRVIHKGLQILQPIQNQLERNGN 318
                                       .||:               ..|.|.:||
Mouse   191 ---------------------------YPTS---------------RFGSQCMQP---------- 203

  Fly   319 LSVKPECDSEAEDSGTEDAVDAELEHMELDFECGGNRSGGSDFAINEAVFEQDLLTDVQCAFHVQ 383
                                                                             
Mouse   204 ----------------------------------------------------------------- 203

  Fly   384 PPTLVHSYLNIHYVCETGSRIIFLTIHTLRKVPVFEQLEAHTQVKLLRGVWPALMAIALAQCQGQ 448
                 ::.:.|..:||..:|::|..:...|.:|.|..|:...||.|||..|..|..:..|||...
Mouse   204 -----NNIMGIENICELAARMLFSAVEWARNIPFFPDLQITDQVALLRLTWSELFVLNAAQCSMP 263

  Fly   449 LSV-PTIIGQFIQSTRQLADIDKIEPLKISKMANLTRTLHDFVQELQSLDVTDMEFGLLRLILLF 512
            |.| |.:....:.::...||       ::....:..|...:.|::|::|.|...|:..|:.|:||
Mouse   264 LHVAPLLAAAGLHASPMSAD-------RVVAFMDHIRIFQEQVEKLKALHVDSAEYSCLKAIVLF 321

  Fly   513 NPTL-----------LQQRKERSLRGYVRRVQLYALSSLRRQGGIGGGEERFNVLVARLLPLSSL 566
            ....           ||::.:.:|..|||       |....|      ..||..|:.||..|.::
Mouse   322 TSDACGLSDVAHVESLQEKSQCALEEYVR-------SQYPNQ------PTRFGKLLLRLPSLRTV 373

  Fly   567 DAEAMEELFFANLVGQMQMDALIPFILMTSNT 598
            .:..:|:|||..|||:..::.||..:|::.::
Mouse   374 SSSVIEQLFFVRLVGKTPIETLIRDMLLSGSS 405

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hr78	NP_001189151.1	NR_DBD_TR2_like	47..133	CDD:143525	46/89 (52%)
		NR_LBD_TR2_like	372..595	CDD:132750	58/234 (25%)
Nr2f2	NP_033827.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..72		12/50 (24%)
		NR_DBD_COUP_TF	79..151	CDD:143516	43/71 (61%)
		Interaction with ZFPM2. /evidence=ECO:0000269|PubMed:11382775	117..414		96/521 (18%)
		NR_LBD_COUP-TF	177..411	CDD:132746	71/456 (16%)
		Important for dimerization	337..414		24/82 (29%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167834524
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.840