DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hr78 and nr2c2

DIOPT Version :9

Sequence 1:	NP_001189151.1	Gene:	Hr78 / 40378	FlyBaseID:	FBgn0015239	Length:	601	Species:	Drosophila melanogaster
Sequence 2:	XP_012817160.1	Gene:	nr2c2 / 100038183	XenbaseID:	XB-GENE-482536	Length:	596	Species:	Xenopus tropicalis

Alignment Length:	569	Identity:	161/569 - (28%)
Similarity:	248/569 - (43%)	Gaps:	125/569 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    49 VELCLVCGDRASGRHYGAISCEGCKGFFKRSIRKQLGYQCRGAMNCEVTKHHRNRCQFCRLQKCL 113
            :|.|:||||:||||||||:||||||||||||:||.|.|.||.:.:|.:.||||||||||||:|||
Frog   113 IEYCVVCGDKASGRHYGAVSCEGCKGFFKRSVRKSLTYSCRSSQDCVINKHHRNRCQFCRLKKCL 177

  Fly   114 ASGMRSDSVQHERKPI-VDRKEGIIAAAGSSSTSGGGN------GSSTYLSGKSGYQQGRGKGHS 171
            ..||:.:|||.||||. :.|::....||.:.......:      .:.|::|.|.|.:|
Frog   178 EMGMKMESVQSERKPFDIQREKASNCAASTEKIYIRKDLRSPLIATPTFVSDKDGARQ------- 235

  Fly   172 VKAESAATPPVHSAPATAFNLNENIFPMGLNFAELTQTLMFATQQQQQQQQQHQQSGSYSPDIPK 236
                   |..:.  |....|:                           ||...::.|:.   |..
Frog   236 -------TGLLD--PGVLVNI---------------------------QQPLIREDGTV---ILS 261

  Fly   237 ADPEDDEDDSMDNSSTLCLQLLANSASNNNSQHLNFNAGEVPTALPTTSTMGLIQSSLDMRVIHK 301
            :|.:..|      :|...|..|||..::..:...:.|.|:.....|.......|..:.|  .:.|
Frog   262 SDAKQTE------ASQGGLGTLANVVTSLANLTESLNNGDTADVHPEDQYSSEITRAFD--TLAK 318

  Fly   302 GLQILQ--PIQNQLERNGNLSVKPECDSEAEDSGTEDAVDAELEHMELDFECGGN-RSGGSDFAI 363
            .|...:  |:.|                      ..|.:||         ..||| .....|.|.
Frog   319 ALNTTEGSPVHN----------------------LADGIDA---------STGGNIHIISRDQAT 352

  Fly   364 NEAVFEQDLLTDVQCAFHVQPPTLVHSYLNIHYVCETGSRIIFLTIHTLRKVPVFEQLEAHTQVK 428
            .....|..||:|....|.:..|:.:..|||:||:||:.||::||::|..|.:|.|:.|.......
Frog   353 PILEVEGPLLSDTHVTFKLTMPSPMPEYLNVHYICESASRLLFLSMHWARSIPAFQALGQDCNTN 417

  Fly   429 LLRGVWPALMAIALAQCQGQLSVPTIIGQFIQSTRQLADIDKIEPLKISKMANLTRTLHDFVQEL 493
            |:|..|..|..:.||||...:|:.||:...:...:.....||:...:|.::......|.:|...:
Frog   418 LVRACWNELFTLGLAQCSQVMSLSTILAAIVNHLQNSIQEDKLSGDRIKQVMEHIWKLQEFCNSM 482

  Fly   494 QSLDVTDMEFGLLRLILLFNP-----------TLLQQRKERSLRGYVRRV---QLYALSSLRRQG 544
            ..|.:...|:..|:.::||:|           ...|::.:..|:.||::.   ..|.|:.
Frog   483 TKLGIDGYEYAYLKAVVLFSPDHPGLSSTAQIEKFQEKAQMELQDYVQKTYPDDTYRLAR----- 542

  Fly   545 GIGGGEERFNVLVARLLPLSSLDAEAMEELFFANLVGQMQMDALIPFIL 593
                       ::.||..|..:.:...|||||..|:|.:.:|::||:||
Frog   543 -----------ILVRLPALRLMSSNITEELFFTGLIGNVPIDSIIPYIL 580

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hr78	NP_001189151.1	NR_DBD_TR2_like	47..133	CDD:143525	57/84 (68%)
Hr78	NP_001189151.1	NR_LBD_TR2_like	372..595	CDD:132750	64/236 (27%)
nr2c2	XP_012817160.1	NR_DBD_TR2_like	111..197	CDD:143525	57/83 (69%)
nr2c2	XP_012817160.1	NR_LBD_TR2_like	361..582	CDD:132750	64/236 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	123	1.000	Domainoid score	I5511
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	274	1.000	Inparanoid score	I2904
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D145512at33208
OrthoFinder	1	1.000	-	-		FOG0002998
OrthoInspector	1	1.000	-	-		otm47474
Panther	1	1.100	-	-	O	PTHR24083
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1991
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	7.160