DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Neu2 and zgc:162962

DIOPT Version :9

Sequence 1:	NP_649316.1	Gene:	Neu2 / 40375	FlyBaseID:	FBgn0037085	Length:	382	Species:	Drosophila melanogaster
Sequence 2:	XP_021321964.1	Gene:	zgc:162962 / 798203	ZFINID:	ZDB-GENE-070424-76	Length:	691	Species:	Danio rerio

Alignment Length:	411	Identity:	115/411 - (27%)
Similarity:	180/411 - (43%)	Gaps:	55/411 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 YKCT------GW--QVEKHDPLSN----TICKSCLEDAQNAFDIIETYERSHQFYRFLKDVREEE 72
            |||:      .|  .::.|:.:..    ..|.:|.:..:::.:::....:.|.......:..|||
Zfish   287 YKCSYCEKSFSWSSNLKLHERVHTGEKPYYCPACQKSFRSSQNLLNHTRKCHTITEIKMEFVEEE 351

  Fly    73 SENDGSGCSEEV-------------EAAERDLQDGADDVDSGNEPDINECDIKAKEKPGFSCSHC 124
            .::.|...:..:             |..:.:|:...|:.....||:.|......|.  .|||.||
Zfish   352 IDDLGDSETSRIYKQEETEEQTDPKEVKQENLELNEDEDFLHGEPENNSQTTDTKN--SFSCPHC 414

  Fly   125 PKSFQVKSNLKVHMRSHTGERPFTCSLCPKSFGYSSGLQNHMRTHTGERPFQCSHCPRSFTAGHH 189
            .:||.::::|..|...|:.|||:||..|||||.....|:.|:|.||||:|:.|..|.::|....|
Zfish   415 DRSFTLEASLISHSSIHSRERPYTCPQCPKSFARKDSLRMHLRLHTGEKPYACPQCAKAFAQKEH 479

  Fly   190 LKAHIQMHERRGSLRCPYCQKCFLTSLILKQHLATHTDETQFKCSQCSKSFQVEHELWMHMRVHQ 254
            |..||::|.......|..|...|..|..||.|...||....:.|..|:|.|...|....|:|:|.
Zfish   480 LTIHIRIHTGEKPFVCDQCGSSFARSDSLKNHSRIHTGVKPYSCPHCAKRFTWLHNFRKHIRLHS 544

  Fly   255 -ERLFTCGHCSKDFALHAYLKRHLSRNAR-----CSQSSKA-------SAHKTLGHS--KALKCG 304
             .:.::|..|.|.|...:.||.|:..::.     ||...|:       ..|:.| ||  :...|.
Zfish   545 GVKPYSCEDCGKKFPSASVLKYHMQSHSEERPHSCSTCGKSFIQLDAFKMHQKL-HSGVRPFVCS 608

  Fly   305 KCPKTFTDRSALSTHLKSHTKNKPLLEGPCKSSGSKPAHS---------NAQRKPFKCSSCPRTF 360
            .|.|:|...|.|:.|.:.||..||.   .|...|....||         :...||..|:.|.::|
Zfish   609 HCGKSFNKASNLTEHFRIHTGEKPY---TCSLCGKSFTHSATLKAHERIHTGEKPHHCTQCGKSF 670

  Fly   361 SRKSALLTHLQTHTGKLGTNR 381
            .|.|.||.|::||:.|..|::
Zfish   671 GRASHLLAHVKTHSSKRKTSQ 691

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Neu2	NP_649316.1	zf-AD	1..63	CDD:285071	8/54 (15%)
		COG5048	<119..241	CDD:227381	48/121 (40%)
		C2H2 Zn finger	121..141	CDD:275368	7/19 (37%)
		zf-H2C2_2	133..158	CDD:290200	13/24 (54%)
		C2H2 Zn finger	149..169	CDD:275368	9/19 (47%)
		zf-H2C2_2	162..185	CDD:290200	10/22 (45%)
		C2H2 Zn finger	177..197	CDD:275368	7/19 (37%)
		C2H2 Zn finger	205..225	CDD:275368	7/19 (37%)
		zf-C2H2_8	206..286	CDD:292531	25/85 (29%)
		C2H2 Zn finger	233..253	CDD:275368	7/19 (37%)
		C2H2 Zn finger	260..297	CDD:275368	12/48 (25%)
		C2H2 Zn finger	303..323	CDD:275368	7/19 (37%)
		C2H2 Zn finger	353..373	CDD:275368	8/19 (42%)
zgc:162962	XP_021321964.1	C2H2 Zn finger	65..85	CDD:275368
		C2H2 Zn finger	93..113	CDD:275368
		C2H2 Zn finger	121..141	CDD:275368
		zf-H2C2_2	133..158	CDD:316026
		C2H2 Zn finger	149..169	CDD:275368
		zf-H2C2_2	161..186	CDD:316026
		C2H2 Zn finger	177..197	CDD:275368
		C2H2 Zn finger	205..225	CDD:275368
		zf-H2C2_2	217..242	CDD:316026
		C2H2 Zn finger	233..253	CDD:275368
		COG5048	257..674	CDD:227381	107/392 (27%)
		C2H2 Zn finger	261..281	CDD:275368
		C2H2 Zn finger	289..309	CDD:275368	3/19 (16%)
		C2H2 Zn finger	317..335	CDD:275368	2/17 (12%)
		C2H2 Zn finger	411..431	CDD:275368	7/19 (37%)
		C2H2 Zn finger	439..459	CDD:275368	9/19 (47%)
		C2H2 Zn finger	467..487	CDD:275368	7/19 (37%)
		C2H2 Zn finger	495..515	CDD:275368	7/19 (37%)
		C2H2 Zn finger	523..543	CDD:275368	7/19 (37%)
		C2H2 Zn finger	551..571	CDD:275368	7/19 (37%)
		C2H2 Zn finger	579..599	CDD:275368	5/20 (25%)
		C2H2 Zn finger	607..627	CDD:275368	7/19 (37%)
		C2H2 Zn finger	635..655	CDD:275368	4/19 (21%)
		C2H2 Zn finger	663..683	CDD:275368	8/19 (42%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000003
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.000