Protein Alignment Neu2 and ZNF142

DIOPT Version :10

• Sequence 1: NP_649316.1
• Gene: Neu2 / 40375
• FlyBaseID: FBgn0037085
• Length: 382
• Species: Drosophila melanogaster
• Sequence 2: NP_001353219.1
• Gene: ZNF142 / 7701
• HGNCID: 12927
• Length: 1887
• Species: Homo sapiens
• Alignment Length: 344
• Identity: 89/344 - (25%)
• Similarity: 129/344 - (37%)
• Gaps: 90/344 - (26%)

  Fly    38 CKSCLEDAQNAFDIIETYERSHQFYRFLKDVREEESENDGSGCSEEVEAAERDLQDGADDVDSGN 102
            |:.|...|:....:::.|...|                      ||..||.. ..||  |.|:|.
Human  1582 CQLCDFAARERVGLVKHYLEQH----------------------EETSAAVA-ASDG--DGDAGQ 1621

  Fly   103 EP-DINECDIKAKEKPGFSCSHCPKSFQVKSNLKVHMRSHTGERPFTCSLCPKSFGYSSGLQNHM 166
            .| ....||        |:|.|       :..|..|::.|.|.|.:.|:.|..|......:..|.
Human  1622 PPLHCPFCD--------FTCRH-------QLVLDHHVKGHGGTRLYKCTDCAYSTKNRQKITWHS 1671

  Fly   167 RTHTGERPFQCSHCPRSFTAGHHLKAHIQMHERRGSLRCPYC-QKCFLTSLILKQHLATHTDETQ 230
            |.||||:|:.|..||.:......||.|:::|:......||.| .||...:. ||.|:..||....
Human  1672 RIHTGEKPYHCHLCPYACADPSRLKYHMRIHKEERKYLCPECGYKCKWVNQ-LKYHMTKHTGLKP 1735

  Fly   231 FKCSQCSKSFQVEHELWMHMRVHQERLFTCGHCSKDFALHAYLKRHLSRNARCSQSSKASAHKTL 295
            ::|.:|.........|    |||||                  .||  |.||
Human  1736 YQCPECEYCTNRADAL----RVHQE------------------TRH--REAR------------- 1763

  Fly   296 GHSKALKCGKCPKTFTDRSALSTHLKSHTKNKPLLEGPCK-----SSGSK-PAHSNAQRKPFKCS 354
                |..|.:|.|.|..|..|.|||:.|::.||.:...|.     ::|.: .|.::..|.||.|.
Human  1764 ----AFMCEQCGKAFKTRFLLRTHLRKHSEAKPYVCNVCHRAFRWAAGLRHHALTHTDRHPFFCR 1824

  Fly   355 SCPRTFSRKSALLTHLQTH 373
            .|.....:|..::.|::.|
Human  1825 LCNYKAKQKFQVVKHVRRH 1843

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Neu2	NP_649316.1	zf-AD	1..63	CDD:462262	5/24 (21%)
		COG5048	<119..241	CDD:227381	37/122 (30%)
		C2H2 Zn finger	121..141	CDD:275368	4/19 (21%)
		zf-H2C2_2	133..156	CDD:463886	7/22 (32%)
		C2H2 Zn finger	149..169	CDD:275368	5/19 (26%)
		zf-H2C2_2	162..185	CDD:463886	10/22 (45%)
		C2H2 Zn finger	177..197	CDD:275368	6/19 (32%)
		C2H2 Zn finger	205..225	CDD:275368	8/20 (40%)
		zf-C2H2_8	206..286	CDD:464935	22/80 (28%)
		C2H2 Zn finger	233..253	CDD:275368	4/19 (21%)
		C2H2 Zn finger	260..297	CDD:275368	5/36 (14%)
		C2H2 Zn finger	303..323	CDD:275368	9/19 (47%)
		C2H2 Zn finger	353..373	CDD:275368	4/19 (21%)
ZNF142	NP_001353219.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..23
		C2H2 Zn finger	365..385	CDD:275368
		C2H2 Zn finger	393..413	CDD:275368
		C2H2 Zn finger	421..438	CDD:275368
		C2H2 Zn finger	455..475	CDD:275368
		C2H2 Zn finger	545..566	CDD:275368
		C2H2 Zn finger	574..595	CDD:275368
		zf-H2C2_5	601..625	CDD:404746
		C2H2 Zn finger	603..623	CDD:275368
		C2H2 Zn finger	631..651	CDD:275368
		C2H2 Zn finger	659..679	CDD:275368
		C2H2 Zn finger	687..707	CDD:275368
		C2H2 Zn finger	714..731	CDD:275368
		PHA03247	928..>1219	CDD:223021
		C2H2 Zn finger	1306..1353	CDD:275368
		C2H2 Zn finger	1373..1394	CDD:275368
		C2H2 Zn finger	1402..1422	CDD:275368
		C2H2 Zn finger	1430..1451	CDD:275368
		C2H2 Zn finger	1626..1646	CDD:275368	7/34 (21%)
		C2H2 Zn finger	1654..1674	CDD:275368	5/19 (26%)
		C2H2 Zn finger	1682..1702	CDD:275368	6/19 (32%)
		zf-H2C2_2	1694..1718	CDD:463886	8/23 (35%)
		C2H2 Zn finger	1710..1730	CDD:275368	8/20 (40%)
		zf-H2C2_2	1723..1747	CDD:463886	7/23 (30%)
		C2H2 Zn finger	1738..1759	CDD:275368	8/42 (19%)
		C2H2 Zn finger	1767..1787	CDD:275368	9/19 (47%)
		C2H2 Zn finger	1795..1815	CDD:275368	3/19 (16%)
		C2H2 Zn finger	1823..1843	CDD:275368	4/19 (21%)