DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Neu2 and ZNF7

DIOPT Version :9

Sequence 1:	NP_649316.1	Gene:	Neu2 / 40375	FlyBaseID:	FBgn0037085	Length:	382	Species:	Drosophila melanogaster
Sequence 2:	NP_001336738.1	Gene:	ZNF7 / 7553	HGNCID:	13139	Length:	707	Species:	Homo sapiens

Alignment Length:	384	Identity:	114/384 - (29%)
Similarity:	156/384 - (40%)	Gaps:	76/384 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 CKSCLEDAQNAFDIIETYERSHQFYRFLKDVREEESENDGSGCSEEVEAAERDLQDGADDVDSGN 102
            |:.|.:..:...||...:|.:.|     |..|.:|.:...|.|          ||....:...|.
Human   219 CEECGKGIRATSDIALHWEINTQ-----KISRCQECQKKLSDC----------LQGKHTNNCHGE 268

  Fly   103 EP-DINECD--------------IKAKEKPGFSCSHCPKSFQVKSNLKVHMRSHTGERPFTCSLC 152
            :| :..||.              |...||| |.|:.|.|:|::.|.|..|.|.||||:|:.|..|
Human   269 KPYECAECGKVFRLCSQLNQHQRIHTGEKP-FKCTECGKAFRLSSKLIQHQRIHTGEKPYRCEEC 332

  Fly   153 PKSFGYSSGLQNHMRTHTGERPFQCSHCPRSFTAGHHLKAHIQMHERRGSLRCPYCQKCFLTSLI 217
            .|:||.||.|.:|.|.||||||:.|..|.::|:....|..|.:.|.......|..|.|.|..|..
Human   333 GKAFGQSSSLIHHQRIHTGERPYGCRECGKAFSQQSQLVRHQRTHTGERPYPCKECGKAFSQSST 397

  Fly   218 LKQHLATHTD-----------------------ETQFKCSQCSKSFQVEHELWMHMRVHQ-ERLF 258
            |.||...||.                       |..|||.:|.|:|:....|..|..:|. |:.:
Human   398 LAQHQRMHTGEKAQILKASDSPSLVAHQRIHAVEKPFKCDECGKAFRWISRLSQHQLIHTGEKPY 462

  Fly   259 TCGHCSKDFALHAYLKRHLSRNARCSQSSKASAHKTLGHSKALKCGKCPKTFTDRSALSTHLKSH 323
            .|..|:|.|...:.|.||               .:|....|..||.:|.|.|...|.|..|.:.|
Human   463 KCNKCTKAFGCSSRLIRH---------------QRTHTGEKPFKCDECGKGFVQGSHLIQHQRIH 512

  Fly   324 TKNKPLLEGPC----KSSGSKPAHSNAQR--KPFKCSSCPRTFSRKSALLTHLQTHTGK 376
            |..||.:...|    ..|.|...|....:  ||::|..|.:.||..:.|..|.:.|||:
Human   513 TGEKPYVCNDCGKAFSQSSSLIYHQRIHKGEKPYECLQCGKAFSMSTQLTIHQRVHTGE 571

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Neu2	NP_649316.1	zf-AD	1..63	CDD:285071	6/24 (25%)
		COG5048	<119..241	CDD:227381	52/144 (36%)
		C2H2 Zn finger	121..141	CDD:275368	8/19 (42%)
		zf-H2C2_2	133..158	CDD:290200	12/24 (50%)
		C2H2 Zn finger	149..169	CDD:275368	10/19 (53%)
		zf-H2C2_2	162..185	CDD:290200	11/22 (50%)
		C2H2 Zn finger	177..197	CDD:275368	5/19 (26%)
		C2H2 Zn finger	205..225	CDD:275368	8/19 (42%)
		zf-C2H2_8	206..286	CDD:292531	27/103 (26%)
		C2H2 Zn finger	233..253	CDD:275368	6/19 (32%)
		C2H2 Zn finger	260..297	CDD:275368	8/36 (22%)
		C2H2 Zn finger	303..323	CDD:275368	7/19 (37%)
		C2H2 Zn finger	353..373	CDD:275368	6/19 (32%)
ZNF7	NP_001336738.1	KRAB	25..86	CDD:214630
		PHA02693	64..>137	CDD:333460
		COG5048	239..696	CDD:227381	109/364 (30%)
		C2H2 Zn finger	246..265	CDD:275368	5/28 (18%)
		C2H2 Zn finger	273..293	CDD:275368	2/19 (11%)
		C2H2 Zn finger	301..321	CDD:275368	8/19 (42%)
		C2H2 Zn finger	329..349	CDD:275368	10/19 (53%)
		C2H2 Zn finger	357..377	CDD:275368	5/19 (26%)
		C2H2 Zn finger	385..405	CDD:275368	8/19 (42%)
		C2H2 Zn finger	436..456	CDD:275368	6/19 (32%)
		C2H2 Zn finger	464..484	CDD:275368	7/34 (21%)
		C2H2 Zn finger	492..512	CDD:275368	7/19 (37%)
		C2H2 Zn finger	520..540	CDD:275368	4/19 (21%)
		C2H2 Zn finger	548..568	CDD:275368	6/19 (32%)
		C2H2 Zn finger	576..596	CDD:275368
		C2H2 Zn finger	604..624	CDD:275368
		C2H2 Zn finger	657..677	CDD:275368
		C2H2 Zn finger	685..705	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S3991
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.950