DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Neu2 and Zfp322a

DIOPT Version :9

Sequence 1:	NP_649316.1	Gene:	Neu2 / 40375	FlyBaseID:	FBgn0037085	Length:	382	Species:	Drosophila melanogaster
Sequence 2:	NP_001128556.1	Gene:	Zfp322a / 680201	RGDID:	1594230	Length:	399	Species:	Rattus norvegicus

Alignment Length:	283	Identity:	93/283 - (32%)
Similarity:	124/283 - (43%)	Gaps:	51/283 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   103 EPDINECDIKAK--------EKPGFSCSHCPKSFQVKSNLKVHMRSHTGERPFTCSLCPKSFGYS 159
            |.:.|.|:..|:        ||| :.|..|.|:|...|:|..|.|.|..|:|:.||.|.|||.:.
  Rat    47 EREQNFCENLAQMCERTYTGEKP-YRCDMCEKTFIQSSDLISHQRIHNYEKPYKCSKCEKSFWHH 110

  Fly   160 SGLQNHMRTHTGERPFQCSHCPRSFTAGHHLKAHIQMHERRGSLRCPYCQKCFLTSLILKQHLAT 224
            ..|..|.|||.|::.:.|..|.::|.....|..|.:.|.......|..|.|||..|..|.:|..|
  Rat   111 LALSGHQRTHAGKKFYTCDICGKNFGQSSDLLVHQRSHTGEKPYLCNECDKCFSRSTNLIRHRRT 175

  Fly   225 HTDETQFKCSQCSKSFQVEHELWMHMRVHQ-ERLFTCGHCSKDFALHAYLKRHLSRNARCSQSSK 288
            ||.|..|||.:|.|:|..:.:|..|.|.|. ||.:.|..|.|.:       ||         .|.
  Rat   176 HTGEKPFKCLECEKAFSGKSDLISHQRTHTGERPYKCNKCEKSY-------RH---------RSA 224

  Fly   289 ASAHKTLGHS--KALKCGKCPKTFTDRSALSTHLKSHTKNKPLLEGPCKSSGSKPAHSNAQRKPF 351
            ...||.: |:  |..||..|.|.|..:|.|..|.:.||                      ..||:
  Rat   225 FIVHKRV-HTGEKPYKCSACEKCFGQKSDLIVHQRIHT----------------------GEKPY 266

  Fly   352 KCSSCPRTFSRKSALLTHLQTHT 374
            ||..|.|:|:|.:.|:.|..|||
  Rat   267 KCLECMRSFTRSANLIRHQATHT 289

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Neu2	NP_649316.1	zf-AD	1..63	CDD:285071
		COG5048	<119..241	CDD:227381	46/121 (38%)
		C2H2 Zn finger	121..141	CDD:275368	8/19 (42%)
		zf-H2C2_2	133..158	CDD:290200	12/24 (50%)
		C2H2 Zn finger	149..169	CDD:275368	9/19 (47%)
		zf-H2C2_2	162..185	CDD:290200	8/22 (36%)
		C2H2 Zn finger	177..197	CDD:275368	5/19 (26%)
		C2H2 Zn finger	205..225	CDD:275368	8/19 (42%)
		zf-C2H2_8	206..286	CDD:292531	28/80 (35%)
		C2H2 Zn finger	233..253	CDD:275368	7/19 (37%)
		C2H2 Zn finger	260..297	CDD:275368	8/36 (22%)
		C2H2 Zn finger	303..323	CDD:275368	7/19 (37%)
		C2H2 Zn finger	353..373	CDD:275368	7/19 (37%)
Zfp322a	NP_001128556.1	COG5048	<68..218	CDD:227381	57/150 (38%)
		C2H2 Zn finger	72..92	CDD:275368	8/19 (42%)
		C2H2 Zn finger	100..120	CDD:275368	9/19 (47%)
		C2H2 Zn finger	128..148	CDD:275368	5/19 (26%)
		zf-H2C2_2	140..165	CDD:290200	8/24 (33%)
		C2H2 Zn finger	156..176	CDD:275368	8/19 (42%)
		zf-H2C2_2	168..192	CDD:290200	11/23 (48%)
		C2H2 Zn finger	184..204	CDD:275368	7/19 (37%)
		C2H2 Zn finger	212..232	CDD:275368	8/36 (22%)
		C2H2 Zn finger	240..260	CDD:275368	7/19 (37%)
		C2H2 Zn finger	268..288	CDD:275368	7/19 (37%)
		C2H2 Zn finger	294..314	CDD:275368
		C2H2 Zn finger	322..344	CDD:275368
		C2H2 Zn finger	352..372	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24409
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100