Protein Alignment Neu2 and PRDM9

DIOPT Version :10

• Sequence 1: NP_649316.1
• Gene: Neu2 / 40375
• FlyBaseID: FBgn0037085
• Length: 382
• Species: Drosophila melanogaster
• Sequence 2: NP_064612.2
• Gene: PRDM9 / 56979
• HGNCID: 13994
• Length: 894
• Species: Homo sapiens
• Alignment Length: 306
• Identity: 93/306 - (30%)
• Similarity: 138/306 - (45%)
• Gaps: 48/306 - (15%)

  Fly   119 FSCSHCPKSFQVKSNLKVHMRSHTGERPFTCSLCPKSFGYSSGLQNHMRTHTGERPFQCSHCPRS 183
            :.|..|.:.|..||:|.:|.|.||||:|:.|..|.:.|.:.|.|..|.||||||:|:.|..|.|.
Human   552 YVCRECGRGFSWKSHLLIHQRIHTGEKPYVCRECGRGFSWQSVLLTHQRTHTGEKPYVCRECGRG 616

  Fly   184 FTAGHHLKAH------------------------IQMHERRGSLRCPY-CQKC---FLTSLILKQ 220
            |:....|..|                        :..|:||.:...|| |::|   |....:|..
Human   617 FSRQSVLLTHQRRHTGEKPYVCRECGRGFSRQSVLLTHQRRHTGEKPYVCRECGRGFSWQSVLLT 681

  Fly   221 HLATHTDETQFKCSQCSKSFQVEHELWMHMRVHQ-ERLFTCGHCSKDFALHAYLKRHLSRNA--- 281
            |..|||.|..:.|.:|.:.|..:..|..|.|.|. |:.:.|..|.:.|:..::|.||...:.
Human   682 HQRTHTGEKPYVCRECGRGFSWQSVLLTHQRTHTGEKPYVCRECGRGFSNKSHLLRHQRTHTGEK 746

  Fly   282 -----RCSQSSKASAH-----KTLGHSKALKCGKCPKTFTDRSALSTHLKSHTKNKPLLEGPCKS 336
                 .|.:..:..:|     :|....|...|.:|.:.|.|:|.|.:|.::||..||.:...|..
Human   747 PYVCRECGRGFRDKSHLLRHQRTHTGEKPYVCRECGRGFRDKSNLLSHQRTHTGEKPYVCRECGR 811

  Fly   337 SGSKPAH------SNAQRKPFKCSSCPRTFSRKSALLTHLQTHTGK 376
            ..|..:|      ::...||:.|..|.|.|..||.||.|.:||||:
Human   812 GFSNKSHLLRHQRTHTGEKPYVCRECGRGFRNKSHLLRHQRTHTGE 857

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Neu2	NP_649316.1	zf-AD	1..63	CDD:462262
		COG5048	<119..241	CDD:227381	48/149 (32%)
		C2H2 Zn finger	121..141	CDD:275368	8/19 (42%)
		zf-H2C2_2	133..156	CDD:463886	10/22 (45%)
		C2H2 Zn finger	149..169	CDD:275368	7/19 (37%)
		zf-H2C2_2	162..185	CDD:463886	12/22 (55%)
		C2H2 Zn finger	177..197	CDD:275368	6/43 (14%)
		C2H2 Zn finger	205..225	CDD:275368	7/23 (30%)
		zf-C2H2_8	206..286	CDD:464935	26/92 (28%)
		C2H2 Zn finger	233..253	CDD:275368	6/19 (32%)
		C2H2 Zn finger	260..297	CDD:275368	9/49 (18%)
		C2H2 Zn finger	303..323	CDD:275368	7/19 (37%)
		C2H2 Zn finger	353..373	CDD:275368	9/19 (47%)
PRDM9	NP_064612.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..23
		KRAB	27..85	CDD:214630
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	143..174
		SSXRD	171..201	CDD:430657
		PR-SET_PRDM7_9	240..368	CDD:380970
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	408..469
		COG5048	<528..671	CDD:227381	39/118 (33%)
		C2H2 Zn finger	528..546	CDD:275368
		C2H2 Zn finger	554..574	CDD:275368	8/19 (42%)
		C2H2 Zn finger	582..602	CDD:275368	7/19 (37%)
		C2H2 Zn finger	610..630	CDD:275368	6/19 (32%)
		COG5048	<611..878	CDD:227381	66/247 (27%)
		C2H2 Zn finger	638..658	CDD:275368	2/19 (11%)
		C2H2 Zn finger	666..686	CDD:275368	5/19 (26%)
		C2H2 Zn finger	694..714	CDD:275368	6/19 (32%)
		C2H2 Zn finger	722..742	CDD:275368	6/19 (32%)
		DNA-binding. /evidence=ECO:0000269|PubMed:26833727	730..820		21/89 (24%)
		C2H2 Zn finger	750..770	CDD:275368	2/19 (11%)
		C2H2 Zn finger	778..798	CDD:275368	7/19 (37%)
		C2H2 Zn finger	806..826	CDD:275368	3/19 (16%)
		C2H2 Zn finger	834..854	CDD:275368	9/19 (47%)
		C2H2 Zn finger	862..882	CDD:275368