DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Neu2 and zgc:113343

DIOPT Version :9

Sequence 1:	NP_649316.1	Gene:	Neu2 / 40375	FlyBaseID:	FBgn0037085	Length:	382	Species:	Drosophila melanogaster
Sequence 2:	NP_001014384.1	Gene:	zgc:113343 / 541549	ZFINID:	ZDB-GENE-050327-90	Length:	356	Species:	Danio rerio

Alignment Length:	347	Identity:	106/347 - (30%)
Similarity:	146/347 - (42%)	Gaps:	70/347 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    68 VREEESEN----DGSGCSEEVEAAERDLQDGADDVDSGNEPDINECDIKAKEKPGFSCSHCPKSF 128
            ::|||:|.    |.:..|.:.|...|..|.|...|:.                 .|.||.|.||:
Zfish    10 IKEEETEEQIDADENAVSSQTEDTSRPKQAGRTAVEG-----------------SFICSECGKSY 57

  Fly   129 QVKSNLKVHMRSHTGERPFTCSLCPKSFGYSSGLQNHMRTHTGERPFQCSHCPRSFTAGHHLKAH 193
            :.|.:|..|.|.|:|:..|||:.|.|.|.....|..|||.||||||:.||.|.:|:.....||.|
Zfish    58 KSKDSLYRHTRFHSGQGLFTCTQCGKDFVQKGQLDKHMRIHTGERPYACSQCGKSYNDAATLKMH 122

  Fly   194 IQMHERRGSLRCPYCQKCFLTSLILKQHLATHTDETQFKCSQCSKSFQVEHELWMHMRVHQ---- 254
            .:.|.......|..|.|.|:....||.|..:|.....|.|.||||:|.:|..|..|:.||.
Zfish   123 TKTHSGEKPFTCIQCGKSFIYRKTLKDHQLSHNAVKPFSCDQCSKAFTLEKYLRQHLHVHAAVKP 187

  Fly   255 ------------------------ERLFTCGHCSKDFALHAYLKRHLSRNARCSQSSKASAHKTL 295
                                    |:|:.|.||:|:|.....||.|               .:..
Zfish   188 YVCFCGKSYTTMNMLNEHQRIHTGEKLYQCSHCAKNFTYSNSLKVH---------------QRIH 237

  Fly   296 GHSKALKCGKCPKTFTDRSALSTHLKSHTKNKPLLEGPCKSSGSKPAHSNAQR------KPFKCS 354
            ...|..:|..|.|:||..::|..|.:.||..||.:...|..|.|..:...|.|      ||::||
Zfish   238 TGEKPYRCSSCGKSFTQLASLKAHQRIHTGVKPYVCSDCGKSFSTSSSLTAHRRIHTGEKPYQCS 302

  Fly   355 SCPRTFSRKSALLTHLQTHTGK 376
            .|.::|:|...|..|.:.|||:
Zfish   303 HCGKSFNRTGGLKDHQKVHTGE 324

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Neu2	NP_649316.1	zf-AD	1..63	CDD:285071
		COG5048	<119..241	CDD:227381	50/121 (41%)
		C2H2 Zn finger	121..141	CDD:275368	9/19 (47%)
		zf-H2C2_2	133..158	CDD:290200	11/24 (46%)
		C2H2 Zn finger	149..169	CDD:275368	8/19 (42%)
		zf-H2C2_2	162..185	CDD:290200	14/22 (64%)
		C2H2 Zn finger	177..197	CDD:275368	7/19 (37%)
		C2H2 Zn finger	205..225	CDD:275368	7/19 (37%)
		zf-C2H2_8	206..286	CDD:292531	29/107 (27%)
		C2H2 Zn finger	233..253	CDD:275368	9/19 (47%)
		C2H2 Zn finger	260..297	CDD:275368	8/36 (22%)
		C2H2 Zn finger	303..323	CDD:275368	7/19 (37%)
		C2H2 Zn finger	353..373	CDD:275368	7/19 (37%)
zgc:113343	NP_001014384.1	COG5048	24..>341	CDD:227381	101/333 (30%)
		C2H2 Zn finger	50..70	CDD:275368	9/19 (47%)
		C2H2 Zn finger	78..98	CDD:275368	8/19 (42%)
		zf-H2C2_2	91..114	CDD:290200	14/22 (64%)
		C2H2 Zn finger	106..126	CDD:275368	7/19 (37%)
		zf-H2C2_2	119..143	CDD:290200	8/23 (35%)
		C2H2 Zn finger	134..154	CDD:275368	7/19 (37%)
		C2H2 Zn finger	162..182	CDD:275368	9/19 (47%)
		C2H2 Zn finger	192..209	CDD:275368	0/16 (0%)
		C2H2 Zn finger	217..237	CDD:275368	8/34 (24%)
		zf-H2C2_2	229..254	CDD:290200	8/39 (21%)
		C2H2 Zn finger	245..265	CDD:275368	7/19 (37%)
		zf-H2C2_2	257..282	CDD:290200	8/24 (33%)
		C2H2 Zn finger	273..293	CDD:275368	5/19 (26%)
		zf-H2C2_2	285..310	CDD:290200	8/24 (33%)
		C2H2 Zn finger	301..321	CDD:275368	7/19 (37%)
		zf-H2C2_2	314..338	CDD:290200	5/11 (45%)
		C2H2 Zn finger	329..350	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	0	0.000